Samantha Chill

Dynamic bioinformatician with a PhD in Bioinformatics and Computational Biology and over a decade of experience in computational biology, forensic science, and genomics. Expertise includes next-generation sequencing (NGS) analysis, workflow development using Nextflow and Snakemake, and cloud computing on AWS. Proven ability to lead cross-functional teams and manage large-scale projects that drive innovation in bioinformatics pipelines. Committed to mentoring emerging scientists while applying advanced data science techniques to tackle complex biological challenges.

• Barberio MD, Nadler EP, Sevilla S, Lu R, Harmon B, Hubal MJ., Comparison of visceral adipose tissue DNA methylation and gene expression profiles in female adolescents with obesity., Diabetology & Metabolic Syndrome., 2019
• Barberio, M.D., Sevilla, S., Nadler E.P., Hubal M.J., Insulin Resistance-Related Epigenetic Modifications in Visceral Adipose Tissue of Obese Adolescents: June 3., Medicine & Science in Sports & Exercise, 2016
• Chill, S.S., Vogtmann, E., Sinha, R., Abnet, C., Hicks, B., Jones, K., Hutchinson, A., Dagnall, C., Microbiome Profiling: Assessing the Reliability and Reproducibility of Fecal Extraction., Association of Biomolecular Research Facilities Conference., 03/24/19, San Antonio, TX
• Chill, S.S., Vogtmann, E., Sinha, R., Abnet, C., Hicks, B., Jones, K., Hutchinson, A., Dagnall, C., Impact of fecal extraction on 16S Microbiome Analysis., MadSci Conference, Oral and Poster Presentations., 11/07/19, Philadelphia, PA
• Ewa, T., Avula, L., Joseph, S., Rudloff, M., Sevilla, S., Koparde, V., Zhang, X., Alewine, C., Soluble mesothelin acts as a signaling molecule [abstract]., Proceedings of the American Association for Cancer Research Annual Meeting 2022, 04/08-13/22, Philadelphia, PA
• Ferrante, S., Nadler, E., Pillai, D., Hubal, M., Wang, Z., Wang, J., Gordish-Dressman, H., Koeck, E., Sevilla, S., et al., Adipocyte-derived Exosomal miRNAs: A Novel Mechanism for Obesity-Related Disease., Journal of Pediatric Research, 2013
• Koeck, E., Iordanskaia, T., Sevilla, S., Ferrante, S., Hubal, MJ., Freishtat, RJ., Nadler, EP., Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes: a novel paradigm for obesity-related liver disease., J Surg Res., 2014
• Kuhn, S., Sevilla, S., Steffke, E., Koparde, V., Terabe, M., & Hana, T., METRO., 1.3, 2022, https://doi.org/10.5281/zenodo.6643611
• Nigam, N., Bernard, B., Sevilla, S., Kim, S., Dar, M. S., Tsai, D., Robbins, Y., Burkitt, K., Sievers, C., Allen, C. T., Bennett, R. L., Tettey, T. T., Carter, B., Rinaldi, L., Lingen, M. W., Sater, H., Edmondson, E. F., Moshiri, A., Saeed, A., … Saloura, V., Smyd3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck., Cell Reports, 42, 7, 112823, 2023, https://doi.org/10.1016/j.celrep.2023.112823
• Saeed, A., Sevilla, S., & Saloura, V., Abstract 2228: Genome-wide mapping of smyd3 in HPV-negative head and neck squamous cell carcinoma., Cancer Research, 83, 7_Supplement, 2228–2228, 2023, https://doi.org/10.1158/1538-7445.am2023-2228
• Sevilla, S. and Hubal, M., Genetics of Bariatric Surgery., Seminars in Pediatric Surgery., 2013
• Wu, Z., Han, Y., Wan, Y., Hua, X., Chill, S. S., Teshome, K., Zhou, W., Liu, J., Wu, D., Hutchinson, A., Jones, K., Dagnall, C. L., Hicks, B. D., Liao, L., Hallen-Adams, H., Shi, J., Abnet, C. C., Sinha, R., Chaturvedi, A., & Vogtmann, E., Oral microbiome and risk of incident head and neck cancer: A nested case-control study., Oral Oncology, 137, 106305, 2023, https://doi.org/10.1016/j.oraloncology.2022.106305
• Sinha, S., Panda, A., Nwosu, Z. … Sevilla, S., … Hernandez, JM., IMPACT restrains immuno-metabolic GCN1 signaling to govern pancreatic cancer metastasis [abstract]., Proceedings of the AACR Special Conference in Cancer Research: Pancreatic Cancer, 09/27-30/23, Boston, Massachusetts
• Balachandra, V., Shrestha, R. L., Hammond, C. M., Lin, S., Hendriks, I. A., Sethi, S. C., Chen, L., Sevilla, S., … Basrai, M. A., DNAJC9 prevents CENP-A mislocalization and chromosomal instability by maintaining the fidelity of histone supply chains., EMBO Journal, 43, 2166–2197, 2024, https://doi.org/10.1038/s44318-024-00093-6