Saqlain Haider
St Louis,MO
Summary
Accomplished Senior Scientist with extensive experience at Millipore Sigma, specializing in organic synthesis and process development. Proven track record in designing innovative compounds and optimizing cGMP manufacturing processes. Adept in cross-functional collaboration and skilled in HPLC and crystallization techniques, driving successful project outcomes through strategic problem-solving and teamwork.
Overview
11
11
years of professional experience
Work History
Senior Scientist-Process Chemistry & Product Development
Millipore Sigma
St. Louis, USA
06.2022 - Current
- Design of new compounds based on the review of scientific literature from patents and publications
- Synthesis of APIs, solution phase peptides & organic compounds from grams to multi kilograms scale in cGMP manufacturing
- Enzymatic Oligonucleotide (dATP, dCTP & dGTP) synthesis and its purification using AKTA in process
- Purification of API’s & target compounds using crystallization, ion exchange, affinity, silica gel, and size exclusion
- Instruments used - 600 MHz Bruker, Agilent HPLC & GC, AKTA, Biotage Isolera Four, Buchi Pure C-810 Flash
- Cross-functional collaboration with production, science, management and engineering teams
- CGMP-compliant pharmaceutical manufacturing, including scale-up, technology transfer, and process optimization
- Maintaining strict adherence to regulatory requirements and quality standards through the implementation of validated procedures, robust documentation, and controlled manufacturing environments. Experienced with batch record review, deviation handling, and cross-functional collaboration with QA/QC, production teams, management and engineering teams
Senior Scientist-Medicinal Chemistry
Humanwell Pharmaceutical US
Ballwin, USA
06.2021 - 05.2022
- Synthesis and development of scaffolds as Sigma 1 receptor antagonist and SSTR4 agonist
- Structure based drug design using computational tools like MAESTRO and MOE
- Development of one compound as a PCC lead for Sigma 1 antagonistic activity
- In vitro & in vivo studies of the lead compound followed by PK/PD and toxicity studies.
- Prepared technical dossiers and presented data to R&D and IP teams.
- Working in a multidimensional group including computational chemists, structural biologists, pharmacologists, CROs & FTEs
Senior Research and Development Chemist
University of Mississippi
Oxford, USA
12.2014 - 05.2021
- New methodology for the synthesis of THC & CBD analogues
- Synthesis of hexahydro and octahydrochromanes
- Plant extraction, fractionation, and isolation of pure compounds
- Development of Cabazitaxel and paclitaxel-based prodrugs for the treatment of brain & ovarian cancer
Education
Ph.D. - Identification and Biological Evaluation of Plant Derived and Synthetic Anti-Inflammatory Agents
School of Chemical & Life Sciences, Jamia Hamdard
New DelhiM.Sc. - Industrial Chemistry (1st Division)
Jamia Hamdard
New Delhi, IndiaB.Sc. - Chemistry (1st Division)
University of Allahabad
IndiaSkills
- Organic synthesis
- Process development
- Route scouting and scale-up
- Bruker NMR
- HPLC
- LC-MS
- GC-MS
- IR
- UV
- Karl Fischer
- Crystallization
- Silica gel
- Ion exchange chromatography
- Affinity chromatography
- MS Word
- Excel
- PowerPoint
- ChemDraw
- Mestre Nova
- Sci-Finder
- Dictionary of Natural Products
Book Reviews
- Heterocycles, Back Bone of Drug Design, Journal of Phytochemistry & Biochemistry, 2017, 1, 1
- Handbook of Pharmaceutical Natural Products, Journal of Natural Products, 10.1021/acs.jnatprod.9b00941
References
- Prof. Ikhlas Ahmad Khan, Director, National Center for Natural Products Research (NCNPR) & Program Director FDA, University of Mississippi, USA, ikhan@olemiss.edu
- Dr. Amar Gopal Chittiboyina, Associate Director & Principal Research Scientist, NCNPR, University of Mississippi, USA, amar@olemiss.edu
Selected Patents And Publications
- ACID-LABILE CHEMOTHERAPEUTIC COMPOUNDS AND COMPOSITIONS, US 2023/0000815 A1, James D. McChesney, Amar Gopal Chittiboyina, Suresh Annam, Saqlain Haider, https://patentimages.storage.googleapis.com/11/4d/a6/311853581be2d8/US20230000815A1.pdf
- Balancing the efficacy vs. the toxicity of promiscuous natural products: Paclitaxel-based acid-labile lipophilic prodrugs as promising chemotherapeutics, Saqlain Haider, Patrice Penfornis, Pier Paolo Claudio, James D. McChesney, Amar G. Chittiboyina, European Journal of Medicinal Chemistry, 2021, 227, 113891
- Novel Machaeriol Analogues as Modulators of Cannabinoid Receptors: Structure–Activity Relationships of (+)-Hexahydrocannabinoids and Their Isoform Selectivities, Saqlain Haider, Pankaj Pandey, Chada Raji Reddy, Janet A. Lambert, Amar G. Chittiboyina, ACS Omega, 2021, 6, 31, 20408-20421
- Synthesis of novel 2-mercaptobenzoxazole based 1,2,3-triazoles as inhibitors of proinflammatory cytokines and suppressors of COX-2 gene expression, Saqlain Haider, M. Sarwar Alam, Hinna Hamid, Syed Shafi, Firasat Hussain, Abhijeet Dhulap, Amit Nargotra, Mohammad Shaharyar, Sadiq Umar, Syed Nazreen, Chetna Kharbanda, Yakub Ali, European Journal of Medicinal Chemistry, 2014, 81, 204-217
- 1,5-Dimethylhexylamine (octodrine) in sports and weight loss supplements: Natural constituent or synthetic chemical?, Mei Wang, Saqlain Haider, Amar G. Chittiboyina, Jon F. Parcher, Ikhlas A. Khan, Journal of Pharmaceutical and Biomedical Analysis, 2018, 152, 298-305
- Isoform selectivity of harmine-conjugated 1,2,3-triazoles against human monoamine oxidase, Saqlain Haider, Manal Alhusban, Narayan Chaurasiya, Babu L. Tekwani, Amar G. Chittiboyina, Ikhlas A. Khan, Future Medicinal Chemistry, 2018, 10, 12, 1435-1448
- One-step, stereoselective synthesis of octahydrochromenes via the Prins reaction and their cannabinoid activities, Shuneize Slater, Pradeep B. Lasonkar, Saqlain Haider, Moneerah J. Alqahtani, Amar G. Chittiboyina, Ikhlas A. Khan, Tetrahedron Letters, 2018, 59, 807-810
Timeline
Senior Scientist-Process Chemistry & Product Development
Millipore Sigma
06.2022 - Current
Senior Scientist-Medicinal Chemistry
Humanwell Pharmaceutical US
06.2021 - 05.2022
Senior Research and Development Chemist
University of Mississippi
12.2014 - 05.2021
Ph.D. - Identification and Biological Evaluation of Plant Derived and Synthetic Anti-Inflammatory Agents
School of Chemical & Life Sciences, Jamia Hamdard
M.Sc. - Industrial Chemistry (1st Division)
Jamia Hamdard
B.Sc. - Chemistry (1st Division)
University of Allahabad
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