Sayali Karandikar
Detail-oriented graduate research student with expertise in organic synthesis and chemical biology. Proven ability to conduct interdisciplinary research and contribute to enzyme studies, enhancing understanding of biological mechanisms.
Work History
Graduate Research Student
3 Years1. Elucidated mechanisms of cytochrome P450 enzymes to advance understanding of biosynthesis pathways for biologically relevant natural products.
2. Conducted interdisciplinary research combining organic synthesis and chemical biology.
3. Assisted in work related to other enzyme families like heme based enzymes and non-heme iron enzymes
MSc Project
9 Months1. Worked on photoredox catalyzed arylation reactions of heterocycles.
2. Radical reactions using Diaryliodonium salts as the source of aryl radicals for C-H bond functionalization.
Internship Student
4 Years 8 Months1. Performed Molecular docking and protein modelling to study the interaction and binding of potential drugs with Sars-Cov 2 main protease.
Education
Master of Science - Chemistry
Master of Science - Chemistry
Bachelor of Science - Chemistry
Skills
Publications
1. Organophotoredox-Catalyzed Arylation and Aryl Sulfonylation of Morita–Baylis–Hillman Acetates with Diaryliodonium Reagents
Org. Lett. (2023) 25 (43): 7900–7905.
2. Provision of a Redox Donor to Oxy-Ferrous PrnB Is Required for Pyrrolnitrin Synthesis
Biochemistry (2025) 64 (17): 3760–3770.
3. Mechanistic insights explain divergent radical fate of a common reaction intermediate in Cytochrome P450s AspB and NzeB.
Sayali Karandikar, Justin Cusano Jr., Mark Ruszczycky, Tom Makris, Wei-chen Chang
(manuscript in preparation)
4. Mechanistic insights into a non-heme iron enzyme CloR.
(manuscript in preparation)
Accomplishments
1. Ranked 2nd in IIT Jodhpur M.Sc. Program with a CGPA of 9.04/10
2. Cumulative GPA 3.917/4 at NC State University
3. Secured 3rd rank in B.Sc. Chemistry with a CPI of 9.81/10
4. Presented our undergraduate work titled “ Synthesis of polypyrrole using ferric chloride as oxidant and SLS as dopant" at the two day National conference on “ Materials and their Applications: A broad perspective.