Seyedsaber Mirabdali

Dynamic research professional with a proven track record at North Dakota State University, skilled in advanced molecular biology techniques and data analysis. Recognized for optimizing protocols to enhance data quality and delivering impactful presentations. A collaborative team player committed to driving research excellence and achieving project objectives.

• Kermanshah Pharmacists Association, Member of the Board of Directors, 2016 - 2021
• Association of Brilliant Talents of Kermanshah University of Medical Sciences, 2006 - 2010
• Iranian Pharmacy Students Association, 2003 - 2011

107, 329, 120, 30, 28, 23, 170, 159

• Biochemical Mechanistic Studies
• Antineoplastic Agents Pharmacology
• Metastatic Cell Invasion
• Matrix Metalloproteinases
• Immunophenotyping
• Hepatotoxicity
• Metabolic Diseases
• Heavy Metal Toxicity

• Biopharmacy & Pharmacokinetic, 3.5/4.0
• Toxicology, 4.0/4.0
• Pharmaceutical Biotechnology, 3.8/4.0
• Cell Culture, 3.5/4.0
• Medicinal Chemistry, 3.5/4.0
• Clinical Biochemistry, 3.6/4.0
• Clinical Immunology, 3.0/4.0
• Pharmacology, 3.2/4.0
• Pharmaceutics, 4.0/4.0

• Working with animal models
• Electrophoresis
• Preparation of solutions, Pipetting, pH adjustment, Buffers
• Centrifugation
• Using commercial kits
• Cell culture
• Blotting methods (western, southern, northern)
• Enzyme-Linked Immunosorbent Assay (direct, indirect, sandwich)
• Gel electrophoresis (agarose, native, SDS, reducing SDS)
• Chromatography (HPLC, column, size exclusion, ion exchange, affinity)
• QPCR
• LDH assay
• MTT assay
• Malondialdehyde assay
• Zymography
• Immunohistochemistry
• Flow cytometry
• Haematoxylin/Eosin staining
• Confocal Microscopy

• 2023, 8th annual AAPS-PSCI symposium, 04/22/23, Memorial union, NDSU, Fargo, 0014, 019, Sequence determinants of human junctophilin-2 protein nuclear localization and phase separation, Seyedsaber Mirabdali
• 2025, NDSU Student Research Day – Graduate and Gamma Sigma Delta Posters, 04/10/25, Memorial union, NDSU, Fargo, 008, 008, Cardiac E-C Coupling Protein Junctophilin-2 as a Double-Stranded RNA Sensor: A Novel Role in Cardiomyocyte Innate immunity, Seyedsaber Mirabdali
• 2025, 9th annual AAPS-PSCI symposium, 04/17/25, Memorial union, NDSU, Fargo, 0034, 035, Cardiac E-C Coupling Protein Junctophilin-2 as a Double-Stranded RNA Sensor: A Novel Role in Cardiomyocyte Innate immunity, Seyedsaber Mirabdali
• 2025, American Physiology Summit, 04/24/25 - 04/27/25, Baltimore Convention Center, Baltimore, Maryland, A-1928, S129, Cardiac E-C Coupling Protein Junctophilin-2 Sequesters Immunogenic Double-Stranded RNA within Protein-RNA Condensates, Seyedsaber Mirabdali

Throughout my involvement in community service, I have had the opportunity to make a positive impact on the lives of individuals in the Fargo-Moorhead area. As a member of organizations like the Great Plains Food Bank and Junior Achievement of the Upper Midwest, I have worked to alleviate food insecurity and provide mentorship to youth. At the Great Plains Food Bank, I helped distribute food to families facing hunger, ensuring that both children and elderly community members received nutritious meals. This service has been vital for individuals who might otherwise struggle to meet basic needs, allowing them to focus on other aspects of their lives, such as education and employment. Through Junior Achievement, I mentored students in financial literacy and entrepreneurship. Many of the students expressed how the program inspired them to pursue higher education and take an active role in planning their futures. I have seen how these young people have gained confidence, skills, and a sense of responsibility that will shape their personal and professional paths. Overall, my community service has provided essential resources and opportunities to those I’ve served, empowering them to improve their circumstances and fostering a stronger, more connected community., Great Plains Food Bank, 01/2024-02/2025, I volunteer at the Great Plains Food Bank, where I help sort, package, and distribute food to families in need in the Fargo-Moorhead area., 60, Dorothy Day House, 05/2024-02/2025, I also volunteer at the Dorothy Day House, where I assist in providing meals and shelter for individuals experiencing homelessness., 30, Big Brothers Big Sisters of Fargo-Moorhead Area, 06/2024-02/2025, As a mentor with Big Brothers Big Sisters, I guide and support local youth, offering mentorship and friendship., 24, Through my volunteer experiences, I have gained valuable insights into the importance of community engagement and the impact of service on both individuals and society. Working with organizations like the Great Plains Food Bank, Dorothy Day House, and Big Brothers Big Sisters has taught me the significance of empathy and compassion. I’ve learned to approach every situation with an open heart and mind, understanding that many people face challenges beyond their control. Volunteering in these settings has broadened my perspective, allowing me to appreciate the diversity of needs within the community and the crucial role that support services play in addressing those needs. Additionally, these experiences have sharpened my leadership and communication skills. At the Great Plains Food Bank and the Dorothy Day House, I collaborated with diverse teams, learning how to work effectively in group settings and communicate efficiently under pressure. As a mentor in Big Brothers Big Sisters, I’ve developed the ability to listen attentively and offer guidance in ways that are both supportive and empowering. Overall, these service opportunities have enriched my personal and professional growth, deepening my sense of social responsibility and reinforcing my commitment to giving back to the community while fostering positive change.

Entrepreneurs play a crucial role in society by driving economic development, innovation, and social change., Economic Development: Entrepreneurs are the backbone of economic growth. They create new businesses, which stimulate local and national economies. These businesses diversify markets, introduce new products and services, and foster competition. Entrepreneurs also contribute to GDP growth, job creation, and tax revenue, all of which improve public services and infrastructure., Job Creation: One of the most direct ways entrepreneurs positively impact society is by creating jobs. Small businesses and startups often hire employees from diverse backgrounds, including marginalized communities. This helps reduce unemployment and offers people opportunities for economic stability and growth. Entrepreneurs also offer flexible work options, such as remote or part-time positions, which can improve work-life balance., Innovation and Technological Advancements: Entrepreneurs are key drivers of innovation. They develop new technologies, products, and services that solve complex problems and improve quality of life. Many entrepreneurs focus on addressing global challenges, such as environmental sustainability and public health. For example, eco-friendly technologies or medical breakthroughs can significantly impact society, improving both environmental and human health., Social Impact and Community Building: Social entrepreneurs, in particular, work to solve pressing societal issues like poverty, inequality, and access to education. They often reinvest profits back into local communities to fund initiatives or improve local infrastructure. By focusing on ethical practices, such as fair trade, these entrepreneurs contribute to a more just and sustainable world., Inspiring Others: Entrepreneurs inspire by setting examples of resilience, creativity, and perseverance. Their journey often encourages others to pursue their own entrepreneurial endeavors. Through mentorship and education, entrepreneurs empower the next generation of innovators and problem-solvers., Sustainability and Environmental Impact: Many entrepreneurs focus on creating sustainable business models. They develop green technologies, clean energy solutions, and services that reduce carbon footprints, contributing to the fight against climate change.

I have made significant contributions to advancing our understanding of cellular processes and disease mechanisms through my research in the areas of cardiomyocyte function, apolipoproteins, and autophagy in cancer. One of my key studies uncovered a novel function of Junctophilin-2 (JPH2) as a double-stranded RNA (dsRNA)-binding protein in cardiomyocytes. This discovery revealed JPH2’s role in regulating innate immune responses by inhibiting the activation of MDA5 signaling, which is critical for dsRNA sensing. Our findings highlight JPH2 as a regulator of dsRNA sequestration, emphasizing its potential as a target for modulating immune responses in cardiovascular diseases. In addition, I conducted a systematic review and meta-analysis on the effects of flaxseed supplementation on apolipoproteins. This study provided strong evidence of flaxseed’s beneficial effects on apo-BI and lipo(a) levels, though its impact on apo-AI remained inconclusive. This research contributes to the growing body of knowledge on the role of dietary supplements in lipid metabolism. Furthermore, I have extensively reviewed the complex relationship between autophagy and ovarian cancer. My work focused on how autophagy, a critical cellular process, can both promote and inhibit tumor growth in ovarian cancer, depending on the context. This research has important implications for cancer treatment strategies, including the potential use of autophagy inhibitors in combination with conventional therapies. In all my work, I strive to combine my medical background with advanced pharmaceutical research to address key issues in disease pathogenesis, immune modulation, and treatment development.

• The best pharmacist of the year based on a survey of the pharmacists' association of Kermanshah province, 2016, 2018
• The best employee of the hospital in Paveh province, 2014
• Top researcher of the medical school of Kermanshah University of Medical Sciences, 2012
• Ranked as the second among 90 pharmacy students at the end of PharmD, 2012
• Ranked as the third place of brilliant talents among 460 Ph.D. Students of Kermanshah University of Medical Sciences, 2012
• Winner of the second prize of the best student articles of the 16th national seminar of pharmaceutical students of Iran, 2012
• Winner of the first prize of the best student articles of the 14th national seminar of pharmaceutical students of Iran, 2011
• Winner of the first prize of the best student articles of the 13th national seminar of pharmaceutical students of Iran, 2010
• Ranked within the top 5% among 950 participants in a comprehensive exam of basic pharmaceutical sciences, 2007
• Ranked within the top 0.5 % among approximately 400,000 participants in the National Entrance Exam for Iranian universities, 2003

• Junctophilin-2 is a double-stranded RNA-binding protein that regulates cardiomyocyte-autonomous innate immune response, Shi Y, Mirabdali S, Vetter SW, Guo A, Biochem Biophys Res Commun, 01/01/24, 733, 150725
• Does flaxseed supplementation affect apo-lipoproteins? A GRADE-assessed systematic review and meta-analysis, Benam SP, Mirabdali S, Ebrahimi N, Daneshvar M, Vahedi S, Abbasifard F, Prostaglandins Other Lipid Mediat, 01/01/24, 106872
• Diagnostic performance of ultrasonography for identification of small bowel obstruction; a systematic review and meta-analysis, Motavaselian M, Farrokhi M, Khouzani PJ, Fard AM, Daeizadeh F, Pourrahimi M, Arch Acad Emerg Med, 01/01/24, 12, 1, e33
• The role and function of autophagy through signaling and pathogenetic pathways and lncRNAs in ovarian cancer, Mirabdali S, Ghafouri K, Farahmand Y, Gholizadeh N, Yazdani O, Esbati R, Pathol Res Pract, 01/01/24, 253, 154899
• Optic nerve sheath diameter in predicting the neurological outcomes of cardiac arrest survivors: a systematic review and meta-analysis, Khouzani PJ, Rahmani E, Rezaei M, Benam SP, Fard AM, Amani-Beni R, Arch Acad Emerg Med, 01/01/24, 13, 1, e29
• Artificial intelligence in cancer care: from diagnosis to prevention and beyond, Farrokhi M, Moeini A, Taheri F, Farrokhi M, Mostafavi M, Ardakan AK, Kindle, 01/01/23, 3, 1, 1–149
• Role of regenerative medicine in the treatment of diseases, Rahmani E, Rezaei M, Tavakoli R, Ghadirzadeh E, Sarnaghy FJ, Khorram R, Kindle, 01/01/23, 3, 1, 1–184
• Diverse activity of miR-150 in tumor development: shedding light on the potential mechanisms, Ameri A, Ahmed HM, Pecho RDC, Arabnozari H, Sarabadani H, Esbati R, Cancer Cell Int, 01/01/23, 23, 1, 261
• Investigating the level and activity of MMP-2 and MMP-9 in the serum of heart valve replacement patients referred to Imam Ali Hospital (AS) in Kermanshah, Kayani A, Saeedi MR, Mirabdali S, Karim H, Salehi N, Vis-Raigani A, J Kermanshah Univ Med Sci, 01/01/18, 20, 1, 34–41, Persian
• The study of Livergol effect as an adjunctive drug on serum levels of MMP-2, MMP-9 and VEGF in rheumatoid arthritis patients, Shavandi M, Kiani A, Assar S, Mirabdali S, Iran J Allergy Asthma Immunol, 01/01/18, 17
• Effects of prantschimgin and grandivitin from Ferulago macrocarpa on VEGF, MMP9, MMP2 and research of binding modes using computational methods, Malekshahi Y, Gheibi S, Ghiasvand N, Jafari F, Mirabdali S, Kiani A, Int Pharm Acta, 01/01/18, 1, 1, 92–3
• Effects of dihydropyrano coumarins from Ferulago macrocarpa on VEGF, MMP9, MMP2 and study of binding modes using computational methods, Gheibi S, Ghiasvand N, Jafari F, Mirabdali SS, Kiani A, Shokoohinia Y, Res J Pharmacogn, 01/01/17, 4, Suppl, 111
• Effects of temozolomide on U87MG glioblastoma cell expression of CXCR4, MMP2, MMP9, VEGF, anti-proliferatory cytotoxic and apoptotic properties, Mirabdaly SS, Elieh Ali Komi D, Shakiba Y, Moini A, Kiani A, Mol Biol Rep, 01/01/20, 47, 1187–97
• Synthesis and in-vitro cytotoxicity assessment of N-(5-(benzylthio)-1,3,4-thiadiazol-2-yl)-2-(4-(trifluoromethyl)phenyl)acetamide with potential anticancer activity, Aliabadi A, Hasanvand Z, Kiani A, Mirabdali SS, Iran J Pharm Res, 01/01/13, 12, 4, 687
• Titanium-squarate complex: novel and recyclable Lewis acid catalyst for one-pot synthesis of 3,4-dihydropyrimidinones or their sulfur analogues via solvent-free Biginelli condensation protocol, Adibi H, Mirabdali S, Proceedings of the 13th Seminar of Iranian Pharmacy Students, 01/01/07, Tabriz, Iran

• MAHAK, Non-profit organization to help children with cancer, 2008 - Present
• Nick Bonyaadan Mehregan Organization, Non-profit organization to support and assist families, 2008 - Present

• Professor Asad Vaisi Raygani, Professor, Department of Biochemistry, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Kermanshah, Iran, asadvaisiraygani@kums.ac.ir
• Professor Amir Kiani, Associate Professor, Department of Pharmacology, Pharmacy Faculty, Kermanshah University of Medical Sciences, Kermanshah, Kermanshah, Iran, akiani@kums.ac.ir
• Professor Mohsen Shahlaei, Associate Professor, Department of Medicinal Chemistry, Pharmacy Faculty, Kermanshah University of Medical Sciences, Kermanshah, Kermanshah, Iran, mshahlaei@kums.ac.ir

• 80-Hour workshop on application of SPSS software in medical research, Kermanshah University of Medical Sciences, Kermanshah, Kermanshah, Iran, 2021
• 120-Hour workshop on new targets in cancer treatment, Shiraz University of Medical Sciences, Shiraz, Iran, 2020
• 3-Day workshop on challenges of cell culture, Kermanshah University of Medical Sciences, Kermanshah, Kermanshah, Iran, 2019
• 3-Day workshop on crisis management, Shiraz University of Medical Sciences, Shiraz, Iran, 2016
• 6-Day workshop on rational drug prescription in gastrointestinal diseases and poisoning, Kermanshah University of Medical Sciences, Kermanshah, Kermanshah, Iran, 2015
• 4-Day workshop on hospital infections, antibiotics and challenges, Kermanshah University of Medical Sciences, Kermanshah, Kermanshah, Iran, 2013

Research Assistant, Kermanshah University of Medical Sciences, Kermanshah, Kermanshah, Iran, 03/01/10, 12/01/22, Researching on the culturing of different cancer cell lines to investigate the cytotoxic effects of new anticancer drugs and to determine the extent of their impact on the factors involved in metastasis, determining their biochemical profile, determining the amount, activity, and expression of the MMP2, MMP9, and VEGF gene is the investigation of chemokine receptors cxcr4

Cardiac E-C Coupling Protein Junctophilin-2 Sequesters Immunogenic Double-Stranded RNA within Protein-RNA Condensates

• fisrt place prize in 9th annual AAPS-NDSU research symposium