Summary
Overview
Work History
Education
Skills
Affiliations
LANGUAGES
OUTREACH AND PUBLIC ENGAGEMENT
Publications
Awards
Timeline
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Shalini Datta

Kolkata,India

Summary

Dedicated molecular biologist with a strong foundation in statistics and human genetics, complemented by a solid publication record. Passionate about translational research, biomarker discovery, and assay/product development, with a keen interest in advancing cancer genomics from bench to bedside. Committed to problem-solving through a multidisciplinary approach, with excellent organizational and multitasking skills. I also enjoy mentoring students and scholars in genomics and human genetics, fostering their growth and enthusiasm for research.

Overview

20
20
years of professional experience

Work History

Assistant Professor

John C. Martin Centre for Liver Research and Innovations (JCMLRI)
01.2024 - Current
  • Research Focus: Pathophysiology, ultrastructural and histopathological changes in MASLD.

Research Visiting Scholar

Moffitt Cancer Center, Lab of Prof. Megan Hitchins
06.2025 - 09.2025
  • Research Focus: Methylation-based circulating tumor DNA biomarker for early detection of cancer.

Postdoctoral Research Fellow, Lab of Dr. Laura Wood

Johns Hopkins University School of Medicine
01.2022 - 11.2023
  • Proposed and implemented research focused on understanding the microenvironment precancerous and cancerous lesions of pancreas by using genomics, spatial transcriptomics, spatial proteomics, immune-oncology and artificial intelligence.
  • Work closely with clinicians, collaborators within institute to conduct hands-on experiments and achieve project goals and timeline.

Ramanujan Fellow

Indian Statistical Institute
11.2016 - 11.2021
  • Conducted research to identify genomic and transcriptomic alterations in gastric cancer patients in the Indian subcontinent.
  • Provided mentorship and supervision to students, giving advice on study skills and helping with learning problems.
  • Budget and finance management of projects 2 independent research grants, ensuring all work is completed within assigned budget.

Postdoctoral Research Fellow, Lab of Prof. Jessica Zucman Rossi

INSERM
02.2014 - 10.2015
  • Implemented research focused on understanding specific role of adeno-associated virus in development of hepatocellular carcinoma.
  • Developed molecular biology assay for detection and assess the viral load of AAV2 in human liver tissue.

Project Assistant

Indian Statistical Institute, Kolkata
02.2006 - 08.2007
  • Mentor: Prof. Partha Pratim Majumder.
  • Title: DNA sequence variation in Indian population.

Education

Ph.D. - Biotechnology, Molecular Human Genetics

University of Calcutta
Kolkata, West Bengal
06.2013

Master of Science - Biochemistry

University of Calcutta
Kolkata, West Bengal
06.2003

Bachelor of Science - Zoology (H), Chemistry, Botany, Environmental Science

Gurudas College: Affiliated University of Calcutta
Kolkata, West Bengal
06.2001

Skills

  • Drive research from the lab to clinical milestones through collaboration with clinicians and cross-functional teams
  • Focus on high-impact research addressing critical unmet medical needs
  • Design, execute, and interpret functional assays to uncover mechanisms of action, contributing to data-driven scientific discussions
  • Propose innovative projects, communicate study plans effectively, and provide leadership in advancing research initiatives

Affiliations

  • Associate member of The American Association for Cancer Research.
  • Member of Indian Association of Cancer Research.
  • Review Editor on the Editorial Board of Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers (specialty section of Frontiers in Oncology).
  • Review Editor on the Editorial Board of Journal of Gastroenterology and Hepatology (Wiley).

LANGUAGES

English
Hindi
Bengali
French (basic level)

OUTREACH AND PUBLIC ENGAGEMENT

  • Mindhunt Bengali Thinkers - YouTube Channel
  • Role: Content creator
  • Description: Involved in the Mindhunt Bengali Thinkers YouTube channel and outreach program to disseminate science to the general population and students. Engaged in creating and presenting content that makes complex scientific concepts accessible and interesting to a broad audience, fostering a greater understanding and appreciation of science.

Publications

  • Jamous KT, Damanakis AI, Cornwell AC, Jongepier M, Trujillo MA, Pflüger MJ, Kawalerski R, Maalouf A, Hirose K, Datta S, Stipes A, Pedro BA, Gudmundsson E, Assarzadegan N, Engle L, Scharpf RB, Kawamoto S, Thompson ED, Wood LD. Tumor immune microenvironment alterations associated with progression in human intraductal papillary mucinous neoplasms. J Pathol 2025;259(2). https://doi.org/10.1002/path.6402.
  • Saha S, Mukherjee C, Basak D, Panja P, Mondal PK, Ghosh R, Halder A, Chowdhury A, Dhali GK, Chattopadhyay BK, Ghosh S, Nath S, Datta S. High expression of mesothelin in plasma and tissue is associated with poor prognosis and promotes invasion and metastasis in gastric cancer. Adv Cancer Biol Metastasis 2023;7(1). https://doi.org/10.1016/j.adacne.2023.100098. (Corresponding author)
  • Jeong YJ, Knutsdottir H, Shojaeian F, Lerner MG, Wissler MF, Henriet E, Ng T, Datta S, Navarro-Serer B, Chianchiano P, Kinny-Köster B, Zimmerman JW, Stein-O'Brien G, Gaida MM, Eshleman JR, Lin MT, Fertig EJ, Ewald AJ, Bader JS, Wood LD. Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasion. J Clin Invest 2023;133(8). https://doi.org/10.1172/JCI162054.
  • Basak D, Jamal Z, Ghosh A, Mondal PK, Dey Talukdar P, Ghosh S, Ghosh Roy B, Ghosh R, Halder A, Chowdhury A, Dhali GK, Chattopadhyay BK, Saha ML, Basu A, Roy S, Mukherjee C, Biswas NK, Chatterji U, Datta S. Reciprocal interplay between asporin and decorin: implications in gastric cancer prognosis. PLoS One 2021;16(8). https://doi.org/10.1371/journal.pone.0255915. (Corresponding author)
  • La Bella T, Imbeaud S, Peneau C, Mami I, Datta S, Bayard Q, Caruso S, Hirsch TZ, Calderaro J, Morcrette G, Guettier C, Paradis V, Amaddeo G, Laurent A, Possenti L, Chiche L, Bioulac-Sage P, Letouzé E, Nault JC, Zucman-Rossi J. Adeno-associated virus type 2 (AAV2) induces recurrent insertional mutagenesis in human hepatocellular carcinomas. Gut 2020;69(4). https://doi.org/10.1136/gutjnl-2019-318281.
  • Mazumder S, Datta S, Ray JG, et al. Liquid biopsy: miRNA as a potential biomarker in oral cancer. Cancer Epidemiol 2019;58(1). https://doi.org/10.1016/j.canep.2018.12.008.
  • Nault JC, Mami I, La Bella T, Datta S, Imbeaud S, Franconi A, Mallet M, Couchy G, Letouzé E, Pilati C, Verret B, Blanc JF, Balabaud C, Calderaro J, Laurent A, Letexier M, Bioulac-Sage P, Calvo F, Zucman-Rossi J. Wild-type AAV insertions in hepatocellular carcinoma do not inform debate over genotoxicity risk of vectorized AAV. Mol Ther 2016;24(4). https://doi.org/10.1038/mt.2016.47.
  • Nault JC, Datta S, Imbeaud S, et al. Adeno-associated virus type 2 as an oncogenic virus in human hepatocellular carcinoma. Mol Cell Oncol 2016;3(2). https://doi.org/10.1080/23723556.2015.1095271.
  • Nault JC, Datta S, Imbeaud S, et al. AAV2 and hepatocellular carcinoma. Hum Gene Ther 2016;27(3). https://doi.org/10.1089/hum.2016.002.m.
  • Nault JC, Datta S, Imbeaud S, et al. Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas. Nat Genet 2015;47(10). https://doi.org/10.1038/ng.3389. (Co-First Author)
  • Cao Q, Imbeaud S, Datta S, et al. Authors' response: virus-host interactions in HBV-related hepatocellular carcinoma: more to be revealed? Gut 2015;64(5). https://doi.org/10.1136/gutjnl-2014-308842.
  • Datta S, Chowdhury A, Ghosh M, et al. A genome-wide search for non-UGT1A1 markers associated with unconjugated bilirubin level reveals significant association with a polymorphic marker near a gene of the nucleoporin family. Ann Hum Genet 2012;76(1). https://doi.org/10.1111/j.1469-1809.2011.00688.x. (First Author)

Awards

Received AACR Scholar-in-Training Awardin American Association of Cancer Research (AACR) Annual Meeting 2015, Philadelphia., Early Career Research fellowship (ECR/2017/002633) Department of Science and Technology, Government of India, Ramanujan fellowship (SB/S2/RJN- 151/2015), Science and Engineering Research Board (SERB)

Timeline

Research Visiting Scholar

Moffitt Cancer Center, Lab of Prof. Megan Hitchins
06.2025 - 09.2025

Assistant Professor

John C. Martin Centre for Liver Research and Innovations (JCMLRI)
01.2024 - Current

Postdoctoral Research Fellow, Lab of Dr. Laura Wood

Johns Hopkins University School of Medicine
01.2022 - 11.2023

Ramanujan Fellow

Indian Statistical Institute
11.2016 - 11.2021

Postdoctoral Research Fellow, Lab of Prof. Jessica Zucman Rossi

INSERM
02.2014 - 10.2015

Project Assistant

Indian Statistical Institute, Kolkata
02.2006 - 08.2007

Master of Science - Biochemistry

University of Calcutta

Bachelor of Science - Zoology (H), Chemistry, Botany, Environmental Science

Gurudas College: Affiliated University of Calcutta

Ph.D. - Biotechnology, Molecular Human Genetics

University of Calcutta