Shweta Malik
Albany,NY
Summary
Postdoctoral researcher with expertise in protein biochemistry and cardiovascular signaling. Ph.D.-trained in biophysical and proteomic characterization of amyloid-like protein aggregates, with multiple peer-reviewed publications in high-impact journals. Currently focused on cardiac hypertrophy, redox regulation, and phospho-signaling using cellular and ex vivo heart models. Strong background in mechanistic, hypothesis-driven research bridging proteostasis and cardiovascular disease.
Overview
10
10
years of professional experience
Work History
Postdoctoral Researcher
University At Albany - Suny
Albany, NY
01.2025 - Current
Understanding the molecular mechanisms controlling protein tyrosine phosphatase oxidation and downstream thyroid hormone signaling in cardiac hypertrophy. Ultimately, my goal is to develop novel PTP1B-targeting peptides that destabilizes the oxidized form of PTP1B and increase its catalytic activity in vivo as a potential therapeutic strategy.
Research Scholar
Central University of Rajasthan
Ajmer
01.2019 - 01.2025
- Department of Biotechnology, School of Life Sciences
Dissertation
National Institute of Plant Genome Research
New Delhi, India
01.2017 - 06.2017
- Title- Phylogenetic Study of Developmentally important miR172 in Plants
- Supervisor: Dr. Ananda K. Sarkar
Intern
Defence Institute of Physiology and allied sciences
New Delhi, India
05.2016 - 06.2016
- Training on Techniques: Cell Culture technique, Stereotaxy, Non-invasive blood pressure of rats, Dissection of rat when exposed to heat stress, Morris water maze, IHC, and 2D electrophoresis
- Supervisor: Dr. R. C. Meena
Education
Ph.D. - Biotechnology
Central University of Rajasthan
Ajmer06-2025
M.Sc. - Biotechnology
Amity University
Haryana, India01-2017
B.Sc. - Botany
University of Delhi
India01-2015
Skills
- Bioinformatics and Computer Skills: Knowledge of Computational and Statistical analysis of biological systems by using software viz Graphpad Prism, BLAST, TANGO, Aggrescan, Zyggregator, CPPPred, AmylPred, and Phylogenetic analysis of RNA using software like MEGA6, miRBase, and many more
- Proteomics: Isolation of Proteins and purification, Characterization of amyloidogenic protein aggregates by using dye-based assays like Congo Red, Thioflavin T and ANS SDS-PAGE, Native, Western Blot, Circular Dichroism, Dynamic Light, Scattering, TEM, LC-MS, Aggregation kinetics, Co-Immunoprecipitation, Cysteinyl labeling assay
- Microbial Techniques: Antimicrobial assays against Bacterial strains using Agar well-diffusion, Agar disc-diffusion, and Broth Microdilution, Cloning
- Cell toxicity Techniques: Cell toxicity assays by MTT, Absorbance based and Resazurin assay, Plasmid isolation, Cell transfection, Animal Model Handling, Myocyte isolation, Langendorff Heart Perfusion, Fluorescent imaging and analysis
Accomplishments
Qualified CSIR-NET (AIR Rank-36), 2018
Received ICMR-SRF Fellowship, 2021
Publications and Conferences
- Shweta Malik, Indranil De, Manish Singh, Charis S. Galanakis, Abdulhakeem S. Alamri, Jay Kant Yadav, Isolation and Characterization of milk-derived amyloid-like protein aggregates from Cottage Cheese, 2021, Food Chemistry (Elsevier), Impact factor-9.231
- Neelam Jangir, Shreya Bangarawa, Tamanna Yadav, Shweta Malik, Abdulhakeem S. Alamri, Charis M. Galanakis, Manish Singh, Jay Kant Yadav, Isolation and characterization of amyloid-like protein aggregates from soy chunk and effect of low pH and heat-treatment on their stability, 2022, Journal of Food Biochemistry (Wiley), Impact factor- 3.654.
- Shweta Malik, Jay Kant Yadav, Amyloids and amyloid-like protein aggregates in Food System: Challenges and Perspectives, 2022, Current Protein & Peptide Science, Impact Factor- 3.118
- Abhishek Singh Yadav, Shweta Malik, Indranil de, Bhumika pippal, Manish Singh, Neha Jain, Jay Kant Yadav, Isolation of Amyloid-like protein aggregates (APA) from white bread and their characterisation, 2023, Biophysical Chemistry, Impact Factor- 3.8
- Participation in Webinar on Current Regulatory Guidelines and Ethical Requirement for Clinical Trials in INDIA, Organised by Institutional Human Ethics Committee, BITS Pilani, INDIA August 21, 2020
- International Webinar on Biotechnological Interventions in the fight against COVID-19, organised by Kuwait Institute for Scientific Research, Kuwait June 12, 2021
- Abstract Submission (Title: Targeted disruption of Protein homeostasis of Mycobacterium Tuberculosis by intrinsically designed amyloidogenic Peptide derived from signal sequence of LpqB) in International Symposium on Bioinformatics for Disease Therapeutics, organised by VIGNANS University, INDIA December 21, 2020
- Conference on Amyloids in Disease to Promising material, organised by Indian Institute of Technology, Kanpur, INDIA December 7, 2019
- Poster Presentation (Title: Isolation and Characterization of Milk-derived amyloid-like aggregates from Cottage Cheese) at 44th Indian Biophysical Society Meeting, 2022 entitled Conceptual Advances in Biophysics and its Applications March 30, 2022
- Poster Presentation (Title: Isolation and Characterization of Milk-derived amyloid-like aggregates from Cottage Cheese) at IUFoST 2022 World Congress on Food Science and Technology in Singapore October 31st to November 3rd, 2022
Trainings
Participation in DST-ICPS Sponsored National Workshop on “Perspective of Big Data Analysis in Biological Sciences” Organised by the School of Life Sciences, Central University of Rajasthan. March 27 to 29, 2023
Declaration
I hereby Declare that the particulars furnished herein by me are true to the best of my knowledge and belief.
Timeline
Postdoctoral Researcher
University At Albany - Suny
01.2025 - Current
Research Scholar
Central University of Rajasthan
01.2019 - 01.2025
Dissertation
National Institute of Plant Genome Research
01.2017 - 06.2017
Intern
Defence Institute of Physiology and allied sciences
05.2016 - 06.2016
M.Sc. - Biotechnology
Amity University
B.Sc. - Botany
University of Delhi
Ph.D. - Biotechnology
Central University of Rajasthan