Sina O'Sullivan (Manthey)

Non-invasive cardiologist specializing in cardiac imaging, with special interest in women's cardiovascular health and cardiac diseases during pregnancy.

• American Board of Internal Medicine - Cardiology certification
• Board certification in Special Competence in Adult Echocardiography (ASCeXAM)
• American Board of Internal Medicine certification
• Educational Commission for Foreign Medical Graduates (ECFMG) Licensure
• Advanced Cardiovascular Life Support (current)
• Basic Life Support (current)

• American College of Cardiology, Reproductive Health and Cardio-obstetrics section
• Diversity, Equity and Inclusion Committee, Mayo Clinic Florida
• American College of Cardiology, Women in Cardiology Committee
• American College of Cardiology Florida Chapter, Fellows in Training
• Cardiology Club, EKG education officer, Pennsylvania Hospital
• Heart Failure Committee, Pennsylvania Hospital
• Quality Improvement Committee, Pennsylvania Hospital

• American College of Cardiology
• American Heart Association
• American College of Physicians
• European Society of Cardiology

• Volunteers in Medicine and Sulzbacher Health Center, Jacksonville, USA - Providing cardiovascular care to uninsured patients
• Austrian Medical Students' Association, Local Exchange Officer, Vienna, Austria - Organized and managed international exchange programs, handling logistics, student support, and institutional coordination

• 02/2025 - 03/2025, Cardio-obstetrics, Vanderbilt University Hospital, Nashville, Tennessee, USA
• 01/2017 - 04/2017, Department of Internal Medicine, Pennsylvania Hospital, Pennsylvania, USA
• 07/2016 - 09/2016, Department of Obstetrics and Gynecology, Westmead Hospital, Sydney, Australia
• 09/2015 - 01/2016, Erasmus Exchange Program at the School of Medicine, University of Bologna, Bologna, Italy
• 08/2014 - 09/2014, Department of Obstetrics and Gynecology, Hospital de la Mujer, Zacatecas, Mexico

Award for Best Poster at Cardiovascular Institute 4th Annual Cardiology Fellows Program, 02/2020, Philadelphia, Pennsylvania, USA

Book Chapter

• Cardiac Imaging in Women with Suspected Ischemic Heart Disease, O'Sullivan S, Pollak A, Biology of Women’s Heart, 313-327, Springer, 12/2023, https://link.springer.com/book/9783031399275

Peer-reviewed Abstracts and Papers

• O'Sullivan S, Reddy P, Parikh P, El Sabbagh A, Pollak P. Management of single leaflet device attachment (SLDA) in the tricuspid position - A case series. Accepted and in print at JACC Case Reports, March 2025.
• O'Sullivan S, Wierenga K, Layman A, Yamani M. Mitochondrial disease as a rare cause of cardiomyopathy and complete heart block. JACC. 2025 Apr, 85 (12_Supplement) 3065. doi.org/10.1016/S0735-1097(25)03549-1
• Saad JM, O'Sullivan S, El Sabbagh A, Zoghbi WA. The continuity equation is superior to the pressure half-time method in calcific mitral stenosis: a comparison with cardiac catheterization. Eur Heart J Cardiovasc Imaging. 2025 Jan 31;26(2):313-315. doi: 10.1093/ehjci/jeae253. PMID: 39365150.
• O'Sullivan S, Howard B, Yamani M. Overlap phenotype of left ventricular non-compaction and arrhythmogenic left ventricular cardiomyopathy in a patient with recurrent stroke. JACC. 2024 Apr, 83 (13_Supplement) 3203. doi.org/10.1016/S0735-1097(24)05193-3
• O'Sullivan S, Lara A, Jhawar N, Johnson P, Adedinsewo D. Differences in mortality among women of childbearing age diagnosed with peripartum cardiomyopathy versus other forms of cardiomyopathy. Journal of the American College of Cardiology. 81. 2320. doi: 10.1016/S0735-1097(23)02764-X.
• Jhawar N, O'Sullivan S, Lara A, Johnson P, Adedinsewo, D. Frequency of left ventricular assist device therapy and heart transplant among women of reproductive age diagnosed with peripartum cardiomyopathy. Journal of the American College of Cardiology. 81. 2140. doi: 10.1016/S0735-1097(23)02584-6.
• Morales-Lara A, Johnson P, Douglass E, O'Sullivan S, Yamani M, Noseworthy P, Carter R, Adedinsewo D. Artificial intelligence-based risk stratification of atrial fibrillation among women with peripartum cardiomyopathy compared to other cardiomyopathies. (2022) European Heart Journal. 43. doi: 10.1093/eurheartj/ehac544.2503.
• Adedinsewo D, Morales-Lara A, Douglass E, O'Sullivan S, Young K, Burnette D, Spertus J, Butler-Tobah Y, Rose C, Carter R, Noseworthy P, Phillips S. Relationship between cardiovascular symptoms, health status assessment and cardiomyopathy in the obstetric population (2022) European Heart Journal. 43. doi: 10.1093/eurheartj/ehac544.2600.
• O’Sullivan S, Pierre K, El Sabbagh A, Landolfo C, Yamani, M. Percutaneous closure of focal mitral annular calcification with mitral leaflet perforation in a high-risk surgical patient. (2022) Journal of the American College of Cardiology. 79. 2897. doi: 10.1016/S0735-1097(22)03888-8.
• Morales-Lara A, Douglass E, O’Sullivan S, Johnson P, Yamani M, Adedinsewo D. Differences in atrial fibrillation occurrence among women with and without peripartum cardiomyopathy. Journal of the American College of Cardiology. 79. 528. doi: 10.1016/S0735-1097(22)01519-4.
• Prenner SB, Ambrose M, Gopal D, Manthey S, Spears J, Sussman A, Baston C. Pragmatic assessment of resident performed cardiac point of care ultrasound using a validated scoring metric. Int J Cardiol Heart Vasc. 2022 Mar 11;39:100993. doi: 10.1016/j.ijcha.2022.100993.
• Spears J, Al-Saiegh Y, Goldberg D, Manthey S, Goldberg S. TAVR: A Review of Current Practices and Considerations in Low-Risk Patients. J Interv Cardiol. 2020;2020:2582938. Published 2020 Dec 24. doi: 10.1155/2020/2582938
• Manthey S, Karpenshif Y, Guerraty M. Management of acute coronary syndrome in a patient with factor XI deficiency. Journal of the American College of Cardiology. 2020 Mar 24;75(11 Supplement 1):3029. doi: 10.1016/S0735-1097(20)33656-1
• Spears J, Chetrit D, Manthey S, Lee C , Al-Saiegh Y. Apixaban as a Rare Cause of Leukocytoclastic Vasculitis, Case Reports in Rheumatology, Vol. 2020, Article ID 7234069, February 2020. doi: 10.1155/2020/7234069
• Manthey S, Spears J, Goldberg S. Therapeutic strategies for coexisting carotid and coronary artery disease: which technique and in which order? Case report and review of literature. Journal of Invasive Cardiology, Volume 31, Issue 11, November 2019. doi: 10.1177/117954682095179
• Al-Saiegh Y, Williams P, Barry T, Impens E, Spears J, Manthey S. New Onset Heart Failure Due To Effusive Constrictive Pericarditis Circulation. 2019; doi: 140:A16449

Invited Oral Presentations

• Differences in mortality among women of childbearing age diagnosed with peripartum cardiomyopathy versus other forms of cardiomyopathy, 9th Congress of cardiac diseases in pregnancy, April 2025, Vienna, Austria
• Percutaneous excision of failed MitraClip in the tricuspid valve position, EuroEcho, December 2024, Berlin, Germany
• Cardiac Imaging in Pregnancy, 7th Annual Keys to Cardiac Imaging, September 2023, Key Biscayne, Florida, USA
• Cardiovascular Risk Assessment in Women, Mayo Clinic Cardiovascular Grand Rounds, November 2023, Jacksonville, Florida, USA
• Stress Echocardiography - Step by Step, 6th Annual Keys to Cardiac Imaging, September 2023, Key Biscayne, Florida, USA
• Revascularization strategies for combined carotid and coronary artery disease, Pennsylvania Hospital Cardiovascular Grand Rounds, November 2019, Philadelphia, Pennsylvania, USA
• Imaging didactics for cardiac fellows, July 2024-June 2025, Mayo Clinic Florida, Jacksonville, USA
• As well as presentations in numerous Journal Clubs, Mortality and Morbidity conferences and Morning Reports throughout residency and fellowship

Poster Presentations

• O'Sullivan, S, Wierenga, K, Layman, A. et al. Mitochondrial disease as a rare cause of cardiomyopathy and complete heart block. American College of Cardiology's Annual Scientific Session, April 2025
• O'Sullivan, S, Howard, B, Yamani, M. Overlap phenotype of left ventricular non-compaction and arrhythmogenic left ventricular cardiomyopathy in a patient with recurrent stroke. American College of Cardiology's Annual Scientific Session, April 2024
• O'Sullivan S, Morales-Lara A, Jhawar N, Johnson P, Adedinsewo D. Differences in mortality among women of childbearing age diagnosed with peripartum cardiomyopathy versus other forms of cardiomyopathy. American College of Cardiology's Annual Scientific Session, March 2023
• Jhawar N, O'Sullivan S, Morales-Lara A, Johnson P, Adedinsewo, D. Frequency of left ventricular assist device therapy and heart transplant among women of reproductive age diagnosed with peripartum cardiomyopathy. American College of Cardiology's Annual Scientific Session, March 2023
• Morales-Lara A, Johnson P, Douglass E, O'Sullivan S, Yamani M, Noseworthy P, Carter R, Adedinsewo D. (2022). Artificial intelligence-based risk stratification of atrial fibrillation among women with peripartum cardiomyopathy compared to other cardiomyopathies. European Society of Cardiology Congress, August 2022
• Adedinsewo D, Morales-Lara A, Douglass E, O'Sullivan S, Young K, Burnette D, Spertus J, Butler-Tobah Y, Rose C, Carter R, Noseworthy P, Phillips S. (2022). Relationship between cardiovascular symptoms, health status assessment and cardiomyopathy in the obstetric population. European Society of Cardiology Congress, August 2022
• O’Sullivan S, Pierre K, El Sabbagh A, Landolfo C, Yamani, M. Percutaneous closure of focal mitral annular calcification with mitral leaflet perforation in a high-risk surgical patient. American College of Cardiology's Annual Scientific Session, April 2022
• Morales-Lara A, Douglass E, O’Sullivan S, Johnson P, Yamani M, Adedinsewo D. Differences in atrial fibrillation occurrence among women with and without peripartum cardiomyopathy. American College of Cardiology's Annual Scientific Session, April 2022
• Manthey S, Karpenshif Y, Guerraty M. Management of acute coronary syndrome in a patient with factor XI deficiency. American College of Cardiology’s Annual Scientific Session, March 2020
• Manthey S, Emerson S, Schwab P, Zonoozi S, Goldberg S. When is a non-STEMI really a STEMI? Role of history and EKG during left circumflex occlusion. Cardiovascular Institute of Philadelphia 4th Annual Interventional Cardiology Fellows Program, February 2020
• Al-Saiegh Y, Williams P, Barry T, Impens E, Spears J, Manthey S. New Onset Heart Failure Due To Effusive Constrictive Pericarditis. American Heart Association Scientific Sessions, November 2019
• Manthey S, Spears J, Goldberg S. Therapeutic strategies for coexisting carotid and coronary artery
• disease: which technique and in which order? 15th Annual Complex Cardiovascular Catheter Therapeutics (C3): Advanced Endovascular and Coronary Intervention Global Summit, June 2019
• Spears J, Manthey S, Al-Saiegh Y, Goldberg S. Carotid Stenting for High Risk Surgical Patients. 15th Annual Complex Cardiovascular Catheter Therapeutics (C3): Advanced Endovascular and Coronary Intervention Global Summit, June 2019
• Manthey S, Mahmoud Z, Spears J, Goldberg S. Bifurcation stenting involving the Left Main – Hope for the best or prepare for the worst? Cardiovascular Institute of Philadelphia 3rd Annual Interventional Cardiology Fellows Program, February 2019
• Spears J, Manthey S, Al-Saiegh Y, Goldberg S. Carotid Stenting for High Risk Surgical Patients. Cardiovascular Institute of Philadelphia, 3rd Annual Interventional Cardiology Fellows Program, February 2019
• Dhawan I, Al-Saiegh Y, Manthey S, Addler J. Not Your Typical Pancreatic Mass. Pennsylvania Society of Gastroenterology Annual Scientific Meeting, September 2018.