Susan Jorgensen
Ossining,NY
Summary
Determined and well-rounded individual with many years working as Scientist within pharmaceutical industry. Sharp and focused professional offering skills in cell biology, molecular biology and microbiology quality control. Microbiologist with extensive experience in many phases of antibiotic and antibody drug discovery. Recent primary experience as a senior scientist conducting in vitro assays and designing in vivo experiments to discover novel anti-macrophage receptor antibodies conjugated to antibiotics for eliminating intracellular bacterial infections. Good communicator dedicated to providing high quality, accurate results as part of multidisciplinary research team. Organized and dependable candidate successful at managing multiple priorities with a positive attitude. Willingness to take on added responsibilities to meet team goals. Great results were always satisfying but working safe was always a priority and serving as safety officer in several departments was valuable. I wish to continue my passion for science in a scientist position to utilize my work experience in research and quality management.
Overview
35
35
years of professional experience
Work History
Senior Scientist
REGENERON PHARMACEUTICAL
06.2010 - Current
- Developed screening assays to aid in the selection of novel lead antibodies for several anti-bacterial targets including anti-macrophage receptor antibody drug conjugates to treat intracellular bacterial infections. One assay lead to the discovered antibody against the bacteria Pseudomonas virulence factor PcrV and the antibody was then used as POC for the AAV gene therapy development program.
- Evaluated and implemented new technologies and laboratory techniques to improve quality and robustness of sample analysis.
- Reviewed technical and professional publications and journals to stay current on recent literature and make more strategic research decisions.
- Detailed study findings and updated research upon new discoveries.
- Obtained quotes and contracted CROs to conduct BSL-3 studies and MIC susceptibility determination of antibiotic resistant gonococcal strains.
- Prepared samples for RNAseq data to determine if macrophage receptor expression is affected by bacterial infection and which host genes are upregulated.
- Developed Pseudomonas biofilm assays to determine anti-bacterial activity of newly synthesized free payloads.
- Recently performing escape mutant virus assays to investigate the immune escape mechanisms of the SARS-CoV-2 variants.
- Developed virulent and/or antibiotic resistant bacterial stains and conducted PCR analysis to detect antibiotic resistance genes.
- Prepared and presented research data at internal group and department meetings.
- Attended professional conferences on biofilms, cytokine research, antibiotic bacteria-resistance and macrophage therapies.
Senior Research Scientist
PFIZER (WYETH) PHARMACEUTICAL
01.2005 - 01.2010
- Conducted pharmacokinetic and statistical analysis of the bioanalytical data from nonclinical studies
- Independently designed protocols and served as study investigator/director supervising non-GLP and GLP in vivo pharmacokinetic studies
- Served as study director on development project teams for several small molecules and reviewed/authored two nonclinical regulatory submissions
- Implemented an automation project with electronic notebook BioBook
- Served as IACUC principal investigator for the department to review and implementation of new protocols.
Research Scientist
WYETH PHARMACEUTICAL
01.2000 - 01.2005
- Conducted pharmacokinetic and statistical analysis of the bioanalytical data from formulation studies and prepared technical memos and reports.
- Independently scheduled and conducted in situ permeability and in vivo bioavailability studies.
- Designed protocols for routine experiments and new experimental in vivo and in vitro experiments.
- Evaluated the histamine release in mast cells with various animal or plant-based excipients.
- Developed and evaluated the transdermal delivery of a small molecule for CMC document required for clinical development.
- Served as safety officer and conducted monthly safety training.
- Served as IACUC principal investigator for the department to review and implementation of new protocols.
Scientist
WYETH PHARMACEUTICAL
01.1995 - 01.2000
- Conducted preliminary evaluation of new antibacterial small molecules.
- Conducted HPLC and bioassay analysis of biosamples, including method development and validation and conducted pharmacokinetic analysis.
- Prepared technical memos and reports.
- Independently designed protocols for routine studies and developing new models.
- Developed new animal models including a mouse pneumonia model established with various organisms in CBA/j Xid mice, completed an evaluation of cytokines for clinical treatment of pneumonia, developed a hollow fiber antiviral model and a uranyl nitrate kidney induced clearance model in mice to predict human pharmacokinetic properties of small molecules.
- Developed virulent and/or antibiotic resistant organisms and conducted PCR to detect resistance genes.
- Independently designed methods to determine percent binding of new antibacterial agents to serum proteins.
- Prepared and presented research data at professional meetings.
- Co-authored manuscripts on antibacterial small molecules.
- Trained new employees on areas of technical expertise.
Control Microbiologist
LEDERLE (WYETH) LABORATORIES
01.1989 - 01.1995
- Conducted microbiological testing (endotoxin and bioburden) for water.
- Conducted microbiological testing (endotoxin, sterility, and bioburden) for raw materials, in-process materials, intermediates, and final product.
- Performed environmental monitoring of clean rooms (under cGMP/cGLP and ISO guidelines).
- Perform microbial characterization for identification and trending.
- Prepared technical memos and reports.
- Review and approve microbiological and analytical data to ensure timely release of all testing.
- Independently designed SOPs for routine testing and new procedures.
- Performed assay validation and equipment qualification/verification on VITEK bacterial identification system.
- Initiated and implemented change control documentation for the use of new media for growth of reference and bacterial contaminants.
- Scheduled and trained technical staff members.
Education
Master of Science - Microbiology/Immunology
New York Medical College
Valhalla, NYBachelor of Arts - Biological Sciences
Binghamton University
Binghamton, NYAssociate of Applied Science - Veterinary Science Technology
SUNY Delhi
Delhi, NYSkills
- Safety Procedures and Environmental Standards
- Assay Development
- Data Collection, Results Analysis and Report Writing
- Research and Publication
- Peer Reviews
- MS Office, Sigma
- Advanced Research Techniques
- Self-Driven and Motivated
- Report Generation
- Data Collection
- Training and Mentoring
- Study Design
- Effective Multitasking
- Equipment Maintenance
Awards
Regeneron Recognition Reward, 2018, for support of in vitro screening assay development for Infectious Diseases Regeneron Recognition Reward, 2019, for support of in vitro screening assay development for Infectious Diseases Above and Beyond Award, 2005, for support of in vivo permeability studies for Bioanalytical R&D Above and Beyond Award, 1998, for outstanding contribution to the operation of Wyeth-Ayerst Research Teamwork Award, 1997, for outstanding Glycylcycline teamwork and contribution to Wyeth-Ayerst Research Above and Beyond Award, 1996, for outstanding contribution to the operation of Wyeth-Ayerst Research
Timeline
Senior Scientist
REGENERON PHARMACEUTICAL
06.2010 - Current
Senior Research Scientist
PFIZER (WYETH) PHARMACEUTICAL
01.2005 - 01.2010
Research Scientist
WYETH PHARMACEUTICAL
01.2000 - 01.2005
Scientist
WYETH PHARMACEUTICAL
01.1995 - 01.2000
Control Microbiologist
LEDERLE (WYETH) LABORATORIES
01.1989 - 01.1995
Master of Science - Microbiology/Immunology
New York Medical College
Bachelor of Arts - Biological Sciences
Binghamton University
Associate of Applied Science - Veterinary Science Technology
SUNY Delhi
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