Swathi Nadendla

Astute Graduate Research Assistant with excellent communication, planning and problem solving abilities. Self-motivated professional passionate about advancing knowledge through high-quality research.

Genomics, Epigenomics, NGS analysis, pipeline development, Precision medicine, Nanopore sequencing, sample to sequence analysis, Infectious disease monitoring

1. Development of portable standalone bioinformatic pipeline for analysis of genomic sequencing data from biological samples, The proposed PSPB will identify and classify viral field samples by comparing them with sequences in the Avian FAD sequence database using only the limited RAM (high-speed accessible memory) available in standard mobile computational devices. The string data structure 'generalized suffix tree' will be utilized to build a representation of all known Avian FAD sequences. This data structure allows the efficient identification and characterization of viral sequences present in field samples.

2.Computational design of peptidomimetics for SARS-CoV-2, ACE-2-RBD (Receptor binding domain of spike protein) interaction is important for SARS-CoV-2 to enter the host cell and cause infection. It is possible to prevent it by peptide mimetics that have higher binding affinity to ACE-2. In this project, it is hereby proposed to design those peptides from reference by altering its sequence, substitution of amino acids based on nature and to study the binding properties of those peptides through molecular docking followed by molecular dynamic (MD) simulations resulting in a multi-mutant peptide with higher affinity and stability.

3. Formulation and evaluation of once daily sustained release tablet of Metformin hydrochloride matrix tablets, In this project, it was observed that a properly designed sustained release formulation of Metformin administered once daily can prevent the plasma level fluctuations that occur due to repeated dosing which is the prior focus to formulate these matrix tablets of Metformin hydrochloride.

• North Central Avian Disease Conference Travel Award
• NAHLN NGS Symposia Travel Award
• Academic Excellence Award
• Student Leader Recognition for IBSS symposium

• Nested PCR for the Sensitive Amplification and Sequencing of the Fusion Gene for Newcastle Disease Virus Sequence typing, Conference: North Central Avian Disease Conference
• Use of Bioinformatic Approaches for Primer Design for Newcastle Disease Virus Sequence Typing from Clinical Samples , Conference: North Central Avian Disease Conference
• Coupling Bioinformatics approaches and Oxford Nanopore (ONT) sequencing for enhanced Diagnosis of Newcastle Disease Virus (NDV) in Poultry, Conference: Interdisciplinary Biological Sciences Symposium

• Exploring putative enteric methanogenesis inhibitors using molecular simulations and a graph neural network Randy Aryee, Noor S. Mohammed, Supantha Dey, B. Arunraj, Swathi Nadendla, Karuna Anna Sajeevan, Matthew R. Beck, A. Nathan Frazier, Jacek A. Koziel, Thomas J. Mansell, Ratul Chowdhury bioRxiv 2024.09.16.613350 (under review)
• Identification of Potential ACE2-Derived Peptide Mimetics in SARS-CoV-2 Omicron Variant Therapeutics using Computational Approaches, Stanly Paul, Swathi Nadendla, and M Elizabeth Sobhia, The Journal of Physical Chemistry Letters 2022 13 (32)
• Formulate and evaluate once daily sustained release tablet of highly soluble drug of metformin HclB. Valli Manalan,* Nadendla Swathi Int. J. Res. Pharm. Sci & Tech., 1(4), 138-145