Thomas Sapienza
Boston,Massachusetts
Summary
Detail-oriented scientist with 5 years of experience in biotech and oligonucleotide chemistry, specializing in R&D and process development, with a strong foundation in manufacturing. Skilled in oligonucleotide synthesis, purification (HPLC), and analytical characterization (MS, UV-Vis), with a proven ability to troubleshoot synthesis challenges, optimize processes, and improve efficiency. Demonstrated professional growth by evolving from hands-on manufacturing to leading process development initiatives, contributing to method development and innovation in oligonucleotide therapeutics and diagnostics. Passionate about driving innovation in the biotech industry, seeking to apply expertise in a dynamic environment.
Overview
8
8
years of professional experience
Work History
Scientist 1
Nitto Avecia
05.2023 - Current
- Process Optimization: Directly contributed to improving purification efficiency by up to 4% by implementing advanced purification techniques learned through executed DOEs.
- Technical Documentation: Authored technical development reports (TDRs) and protocols, ensuring compliance with industry standards and facilitating knowledge transfer.
- Client Collaboration: Engaged with clients and cross-functional teams, presenting data and providing technical expertise to optimize process workflows.
- Experimental Design: Designed and executed Design of Experiments (DOEs) to enhance oligonucleotide synthesis, leading to improved yield and consistency.
Product Development Senior Researcher
Nitto Avecia
11.2021 - Current
- Supported future project acquisitions through POC testing following through with DOE studies and executions.
- Performed manufacturing support for all products through critical chemical sampling and testing.
- Chemical team inventory helping keep track and stocked chemicals needed to support all product development processes.
- Worked with all stages of production from synthesis, chromatography, to UF/DF, freeze-dry to api, and packaging.
- Familiar with Atka-purifiers, synthesizers, UNICORN methods, column packing systems.
Bartender
Lenox Hotel And Suites
07.2021 - Current
- Kept bar presentable and well-stocked to meet customer needs.
- Performed opening and closing duties, printing sales reports, setting up for incoming shift, preparing cash drawers and taking inventory.
- High-End martini bar which requires tact and extreme prioritizing.
Manufacturing Technician II
Nitto Avecia
11.2020 - 11.2021
- Hired as a temp manufacturing tech I, was hired after four months as a manufacturing tech II.
- Worked with synthesizers, DCA HDMIs, waste management, all in a full clean cGMP space.
- Prepared and reviewed standard operating procedures, manufacturing batch records and productivity reports.
- Reviewed PIs, SOPs, helepd with CAPA investigations and root cause analysis as well as scrum activities.
Supplemental Instructor for Organic Chemistry
MCPHS University
09.2016 - 09.2018
- Served as a supplemental instructor for Organic chemistry 1 & 2 at MCPHS University, attending each class as a fellow instructor while walking around and answering the questions of the class.
- Routinely drafted review sessions and course plans, both individually and succulently, with both organic chemistry teachers.
- Designed and implemented two review sessions a week receiving 30-40 students consistently and over a 100 on test weeks.
Pod Instructor for Organic Chemistry Lab 1&2
MCPHS University
09.2016 - 09.2017
- Taught two lab sections a semester for Fall, Spring, and Summer courses.
- Responsible for up to 15 students per pod; grading their work, instructing them on proper lab techniques, and leading the class with demonstrations and directions for each lab.
- Handled all concepts of organic labs 1 and 2 from simple distillations and thin-layer chromatography to purifications and multi-step synthesizes.
- Effectively created an open and warm learning environment by encouraging the students to ask questions and making myself available for any extra help.
Spectroscopic Analysis Lab Instructor
MCPHS University
12.2016 - 05.2017
- Trained and guided the class on various instrumentation and analysis of veritable spectra including; HNMR, CNMR, UV-Vis, fluorescence, and IR.
- Instructed the class in various sample preparation techniques, often giving them unknowns to run on various instruments and to later use their NMR and IR knowledge to identify a compound and explain the spectra.
Education
Bachelor of Science - Chemistry
MCPHS University
Boston, MA05.2018
Skills
- Cross-Functional Collaboration
- Adaptable and Responsible
- Effective Communication
- Project Management
- Research and Development
Volunteering & Research work
Volunteer Morocco Agadir, Morocco
Research Assistant May – June 2016
For more info: volunteermorocco.org/staff-directory-1
- Collaborated with Ibn Zohr University in performing field and bench work to determine pollution content and sustainability of drinking water, well water, and surface waters in GPS targeted regions of Morocco.
- Collected water samples from specific GPS coordinated well systems of Moroccan regions of Agadir & Shtouka-Atibaha.
- Conducted quality control tests and directed test procedures using operated wet methods and instrumentation analysis.
- Drafted the scientific summary of the research and delivered a poster presentation which was covered by MCPHSU through their international center of studies and has done a spotlight regarding my experience.
ACS Poster ID: 2516661
mcphscis.wordpress.com/2016/10/20/volunteer-spotlight-thomas-sapienza-bs-chemistryms-pharmaceutical-chemistry-17/
Volunteer Morocco Agadir, Morocco
Field Coordinator Jun 2015
- Led the team of 4 students, including two Moroccan fellows, in collaboration with local doctors and pharmacists on the task to setup free healthcare clinic in each village we visited. This involved setting up the logistics, guiding the patients in and out and managing our team to have an effective approach.
- Provided free basic health checkups and services (HIV, diabetes, blood pressure & heart rate) to the underprivileged people of remote rural villages.
Timeline
Scientist 1
Nitto Avecia
05.2023 - Current
Product Development Senior Researcher
Nitto Avecia
11.2021 - Current
Bartender
Lenox Hotel And Suites
07.2021 - Current
Manufacturing Technician II
Nitto Avecia
11.2020 - 11.2021
Spectroscopic Analysis Lab Instructor
MCPHS University
12.2016 - 05.2017
Supplemental Instructor for Organic Chemistry
MCPHS University
09.2016 - 09.2018
Pod Instructor for Organic Chemistry Lab 1&2
MCPHS University
09.2016 - 09.2017
Bachelor of Science - Chemistry
MCPHS University
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