Tian Cao
Concord,Massachusetts
Summary
Experienced researcher with a strong background in cerebral vascular disease translation studies and clinical experience. Has demonstrated record of research progress in intracerebral hemorrhage and trauma brain injury studies. With over 6 years of laboratory experience and 2 years in clinical residency. Self-directed and motivated professional with a highly ethical, meticulous, and thorough approach.
Overview
10
10
years of professional experience
1
1
Certification
Work History
Research Fellow
Brigham's & Women's Hospital,Harvard Medical Shool
08.2022 - Current
- Establish mice intracerebral hemorrhage model and traumatic brain injury (TBI) model. Test nasal mucosal tolerance treatment on stroke model. Perform behavioral testing.
- Isolated brain cells for sequencing.
- Performed a variety of biological techniques and assays including immunohistochemistry, q-PCR, antibody staining, flow cytometry, and confocal imaging.
- Isolate PBMCs from healthy donor blood.
- Completed basic lab maintenance tasks such as stocking, ordering, and cleaning.
- Maintained detailed and accurate notes on all experiments performed.
- Mentored two graduate researchers for their experimental techniques.
Graduate Researcher
Mass General Hospital,Harvard Medical Shool
11.2019 - 07.2022
- Establish mice cerebral hemorrhage model and closed head injury model. Focus on RIPK1/3,necroptosis, and inflammation in ICH. Perform behavioral testing.
- Performed biological techniques and assays including western blot, genotyping, immunohistochemistry, q-PCR, and antibody staining. Mice breeding.
Student Researcher, Resident Doctor
Sichuan University
09.2017 - 10.2019
- Performed animal disease model to study stroke. Establish rat cerebral hemorrhage and MCAO model.
- Gathered and organized clinical trial documentation.
- Focus on lacunar infarction from intrinsic cerebral small vessel disease. Reviewed clinical data, imaging data, case report forms, and investigative site regulatory files to verify accuracy and completion
- Clinical rotations
Resident Doctor
West China Hospital, Sichuan University
07.2016 - 08.2017
- Interviewed patients concerning physical complaints, discussed symptoms, asked questions, and suggested treatment options.
- Teamed with other physicians, specialists, and healthcare providers to provide well-rounded care for complex cases.
- clinical rotations.
Student Researcher
Sichuan University
09.2013 - 07.2016
- Learned laboratory techniques such as western blot, genotyping, immunohistochemistry, and q-PCR.
- Conduct the literature review with colleagues.
- Focuses on roles of HMGB1 regulates or participates in intracerebral hemorrhage.
- Collect clinical patient data and follow-up patients via telephone.
- Clinical rotations.
Education
Clinical Medicine，Neurology
Sichuan University, Chengdu
Chengdu,China11.2022
Master of Science - Clinical Medicine，Neurology
Sichuan University
Chengdu,China07.2017
M.D. - Clinical Medicine
North Sichuan Medical College
Chengdu,China07.2013
Skills
- Expertise in Western Blot, q-PCR
- Cell isolation
- Flow cytometry
- Hands-on experience working with rodent animal models (mouse and rat)
- Mice transcardial perfusion and tissue harvesting
- Skilled in mice intracerebroventricular (ICV), intravenous (IV), and Retro-orbital injection
- Stereotaxic surgeries
- Section fixed tissues for immunofluorescence staining
- Cell culture
- Microscopy
Certification
The People's Republic of China Licensed Doctorthe People's Republic of China Licensed Doctor
National Health Commission of the People’s republic of china Issued Dec 2014
MGBE HRA Good Clinical Practice (GCP) E6R2 On
Mass General BrighamMass General Brigham Issued
Dec 2023 · Expires Dec 2033
MGBE HRA Clinical Research Boot Camp On
Mass General BrighamMass General Brigham Issued
Dec 2023 · Expired Dec 2023
Working with the IACUC - Research Investigator, Technician, and Research Staff
CITI Program Credential ID:34494113
Aseptic surgery
CITI Program Credential ID:34494110
Reducing Pain and Distress in Laboratory Mice and Rats
CITI Program Credential ID:34494109
Rodent Anesthesia
CITI Program Credential ID:34494112
Working with Mice in Research
CITI Program Credential ID:34494112
Additional Information
Original Articles
1. Wu L, Kalish BT, Finander B, Cao T, Jin G, Yahya T, Levy ES, Kukreja B, LaRovere ES, Chung JY, Lo EH, Brown-Whalen A, El Khoury J, Kaplan DL, Whalen MJ. Repetitive Mild Closed Head Injury in Adolescent Mice Is Associated with Impaired Proteostasis, Neuroinflammation, and Tauopathy. J Neurosci. 2022 Mar 23;42(12):2418-2432.PMID:35105673
2. Wu L, Chung JY, Cao T, Jin G, Edmiston WJ 3rd, Hickman S, Levy ES, Whalen JA, Abrams ESL, Degterev A, Lo EH, Tozzi L, Kaplan DL, El Khoury J, Whalen MJ. Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis. Cell Death Dis. 2021 Nov 9;12(11):1064.PMID:34753914
3. Jiang S*, Cao T*, Yan Y, Yang T, Yuan Y, Deng Q, Wu T, Sun J, Wu S, Hao ZL, Anderson CS, Wu B. Lenticulostriate artery combined with neuroimaging markers of cerebral small vessel disease differentiate the pathogenesis of recent subcortical infarction. J Cereb Blood Flow Metab. 2021 Aug;41(8):2105-2115.PMID:33563077
4. Feng L, Wu XJ, Cao T, Wu B. The efficacy and safety of Xuesaitong injection combined with western medicines in the treatment of ischemic stroke: an updated systematic review and meta-analysis. Ann Palliat Med. 2021 Sep;10(9):9523-9534. doi: 10.21037/apm-21-1828. PMID: 34628878.
5. Jiang S, Zhong D, Yan Y, Zhu Q, Wang C, Bai X, Cao T, Wu B. Mirror movements induced by hemiballism due to putamen infarction: a case report and literature review. Ann Transl Med. 2020 Jan;8(1):19. doi: 10.21037/atm.2019.10.86. PMID: 32055610; PMCID: PMC6995745.
6. Lei C, Wu B, Liu M, Cao T, Wang Q, Dong W. Differences Between Vascular Structural Abnormality and Hypertensive Intracerebral Hemorrhage. J Stroke Cerebrovasc Dis. 2015 Aug;24(8):1811-6. doi: 10.1016/j.jstrokecerebrovasdis.2015.04.006IF: 2.5 Q3 . Epub 2015 Jun 13. PMID: 26077131.
7. Lei C, Wu B, Liu M, Cao T, Wang Q, Dong W, Chang X. VSARICHS: a simple grading scale for vascular structural abnormality-related intracerebral hemorrhage. J Neurol Neurosurg Psychiatry. 2015 Aug;86(8):911-6. doi: 10.1136/jnnp-2014-308777. Epub 2014 Oct 3. PMID: 25280916.
8. Lei C, Wu B, Cao T, Liu M, Hao Z. Brain recovery mediated by toll-like receptor 4 in rats after intracerebral hemorrhage. Brain Res. 2016 Feb 1;1632:1-8. doi: 10.1016/j.brainres.2015.11.045. Epub 2015 Dec 3. PMID: 26657742
9. Lei C, Wu B, Cao T, Zhang S, Liu M. Activation of the high-mobility group box 1 protein-receptor for advanced glycation end-products signaling pathway in rats during neurogenesis after intracerebral hemorrhage. Stroke. 2015 Feb;46(2):500-6. doi: 10.1161/STROKEAHA.114.006825. Epub 2014 Dec 23. Erratum in: Stroke. 2022 Feb;53(2):e63. PMID: 25538203.
Lei C, Zhang S, Cao T, Tao W, Liu M, Wu B. HMGB1 may act via RAGE to promote angiogenesis in the later phase after intracerebral hemorrhage. Neuroscience. 2015 Jun 4;295:39-47. doi: 10.1016/j.neuroscience.2015.03.032IF: 3.3 Q3 . Epub 2015 Mar 23. Erratum in: Neuroscience. 2022 Jan 15;481:238-239. PMID: 25813710.
Conference poster:
1. Tian Cao, Taha Yahya, Joshua Bernstock, Omar Albastaki, Rafael Machado Rezende, Howard Weiner, Saef Izzy Nasal administration of E-Selectin Improves Chronic Outcomes After Traumatic Brain Injury, Neurocritical Care Society Abstracts from the 21st Annual Meeting 2023. Neurocrit Care 39 (Suppl 1), 1–268 (2023). https://doi.org/10.1007/s12028-023-01814-1
2. S Izzy, T Yahya, T Cao, M Waed, TG Moreira, RM Rezende, H Weiner Modulating CNS neuroinflammation in animal models of intracerebral hemorrhage by nasal anti-CD3 (S4. 010) Neurology 100 (17 Supplement 2)
3. S Izzy, T Yahya, T Cao, O Albastaki, M Waed, K Chopra, MN Ekwudo. Salt diet Induces Neuroinflammatory Response, Microbiome Dysregulation and Associated with Long-term Anxiety Following Repetitive Closed Head Injury. (S28. 003) Neurology 100 (17 Supplement 2)
The original language of publication is Chinese
1. Zhang Huimin, Wu Bo, Cao Tian, Yan Yuying, Liu Ming. Effect of Exogenous Recombinant HMGB1 on Neural Stem Cells and Related Mechanism, J Sichuan Univ (Med Sci Edi) 2017,48(3):394-398
2. Cao Tian, Wu Bo. Research progress of cerebral venous system diseases and cerebral small vessel diseases: Chinese scholars' reports published abroad. Chinese Journal of Contemporary Neurology and Neurosurgery, 2016, 16(11): 745-750.
3. Cao Tian, Wu Bo, Liu Ming. Research progress of acute asymptomatic infarction after spontaneous intracerebral hemorrhage. Chinese Journal of Neurology, 2015,48(10): 901-903. DOI: 10.3760/cma.j.issn.1006-7876.2015.10.019
Honors and Prizes
2019-2021
The State Scholarship China Scholarship Council, the Ministry of Education of P.R. China
2017-2019
Scholarship awardee Sichuan University
2013-2015
Scholarship awardee Sichuan University
Timeline
Research Fellow
Brigham's & Women's Hospital,Harvard Medical Shool
08.2022 - Current
Graduate Researcher
Mass General Hospital,Harvard Medical Shool
11.2019 - 07.2022
Student Researcher, Resident Doctor
Sichuan University
09.2017 - 10.2019
Resident Doctor
West China Hospital, Sichuan University
07.2016 - 08.2017
Student Researcher
Sichuan University
09.2013 - 07.2016
Clinical Medicine，Neurology
Sichuan University, Chengdu
Master of Science - Clinical Medicine，Neurology
Sichuan University
M.D. - Clinical Medicine
North Sichuan Medical College
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