Warren Marcus

Trained scientist with over 20 years of experience in immunology and molecular biology. Co-invented and developed ALT-803, an FDA-approved therapy. Scientific and strategic contributions led to largest biotech acquisition in Florida. Founded WiNK Therapeutics to develop curative treatments for type 1 diabetics and solid tumor patients. Envisions returning to academia to educate future generations in biology and biotechnology.

• HIV VPR-specific T cell receptors Patent number: 8933198 Abstract: The instant invention provides TCRs having one or more amino acid substitutions that bind to the AL9 epitope of the HIV protein vpr (AIIRILQQL (SEQ ID NO: 1)). Date of Patent: January 13, 2015 Inventors: Marilyn Fernandez, Bai Liu, Warren D. Marcus, Hing C. Wong
• HIV VPR-specific T-cell receptors Patent number: 9714279 Abstract: The instant invention provides TCRs having one or more amino acid substitutions that bind to the AL9 epitope of the HIV protein vpr (AIIRILQQL). Date of Patent: July 25, 2017 Inventors: Marilyn Fernandez, Bai Liu, Warren D. Marcus, Hing C. Wong
• HIV VPR-specific T-cell receptors Patent number: 10844107 Abstract: The instant invention provides TCRs having one or more amino acid substitutions that bind to the AL9 epitope of the HIV protein vpr (AIIRILQQL). Date of Patent: November 24, 2020 Inventors: Marilyn Fernandez, Bai Liu, Warren Marcus, Hing C. Wong
• IL-15-based fusions to IL-12 and IL-18 Patent number: 11129883 Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18. Date of Patent: September 28, 2021 Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
• Multimeric IL-15-based molecules Patent number: 11197929 Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule. Date of Patent: December 14, 2021 Inventors: Hing C. Wong, Warren Marcus, Bai Liu, Wenxin Xu, Robert G. Newman, Karen Kage, Lijing You, Peter Rhode, Patrick Soon-Shiong
• Multimeric IL-15-based molecules Patent number: 11318201 Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule. Date of Patent: May 3, 2022 Inventors: Hing C. Wong, Warren Marcus, Bai Liu, Wenxin Xu, Robert G. Newman, Karen Kage, Lijing You, Peter Rhode, Patrick Soon-Shiong
• Multimeric IL-15-based molecules Patent number: 11369679 Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule. Date of Patent: June 28, 2022 Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
• IL-15-based fusions to IL-12 and IL-18 Patent number: 11612645 Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18. Date of Patent: February 7, 2023 Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
• IL-15-based fusions to IL-12 and IL-18 Patent number: 11872272 Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18. Date of Patent: March 28, 2023 Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
• IL-15-based fusions to IL-12 and IL-18 Patent number: 11872272 Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18. Date of Patent: January 16, 2024 Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
• IL-15-based fusions to IL-12 and IL-18 Patent number: 11975059 Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18. Date of Patent: May 7, 2024 Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong

• 1: The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex Caroline Jochems, Sarah R. Tritsch, Karin M. Knudson, Sofia R. Gameiro, Claire Smalley Rumfeld, Samuel T. Pellom, V. Maurice Morillon, II, Robby Newman, Warren Marcus, Christopher Szeto, Shahrooz Rabizadeh, Hing C. Wong, Patrick Soon-Shiong, Jeffrey Schlom Oncoimmunology. 2019; 8(2): e1532764. Published online 2018 Nov 27. doi: 10.1080/2162402X.2018.1532764 PMCID: PMC6343815
• 2: Tissue Factor-Specific Ultra-bright SERRS Nanostars for Raman Detection of Pulmonary Micrometastases Tapas R. Nayak, Chrysafis Andreou, Anton Osseledchyk, Warren D. Marcus, Hing C. Wong, Joan Massagué, Moritz F. Kircher Nanoscale. Author manuscript; available in PMC 2018 Jan 19.Published in final edited form as: Nanoscale. 2017 Jan 19; 9(3): 1110–1119. doi: 10.1039/c6nr08217c PMCID: PMC5438878
• 3: A Novel Fusion of ALT-803 (Interleukin (IL)-15 Superagonist) with an Antibody Demonstrates Antigen-specific Antitumor Responses Bai Liu, Lin Kong, Kaiping Han, Hao Hong, Warren D. Marcus, Xiaoyue Chen, Emily K. Jeng, Sarah Alter, Xiaoyun Zhu, Mark P. Rubinstein, Sixiang Shi, Peter R. Rhode, Weibo Cai, Hing C. Wong J Biol Chem. 2016 Nov 11; 291(46): 23869–23881. Published online 2016 Sep 20. doi: 10.1074/jbc.M116.733600 PMCID: PMC5104912
• 4: Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model Dimitrios Mathios, Chul-Kee Park, Warren D. Marcus, Sarah Alter, Peter R. Rhode, Emily K. Jeng, Hing C. Wong, Drew M. Pardoll, Michael Lim Int J Cancer. Author manuscript; available in PMC 2016 Jan 1.Published in final edited form as: Int J Cancer. 2016 Jan 1; 138(1): 187–194. Published online 2015 Jul 28. doi: 10.1002/ijc.29686 PMCID: PMC4696021
• 5: Enhanced efficacy of ALT-803, an IL-15-based superagonist complex, in combination with immune checkpoint inhibitors in an orthotopic muscle invasive bladder tumor model in mice Wenxin Xu, Karen Kage, Warren D Marcus, Robby Newman, Sarah Alter, Peter R Rhode, Hing C Wong J Immunother Cancer. 2015; 3(Suppl 2): P348. Published online 2015 Nov 4. doi: 10.1186/2051-1426-3-S2-P348 PMCID: PMC4649497
• 6: Combinatorial therapy with an IL-15 superagonist (ALT-803) and anti-PD-L1 mAb augment T cell mediated anti-tumor immunity in mice Christopher B Johnson, Brian Riesenberg, Dan Neitzke, Emily K Jeng, Warren D Marcus, David Cole, Hing C Wong, Mark P Rubinstein J Immunother Cancer. 2014; 2(Suppl 3): P234. Published online 2014 Nov 6. doi: 10.1186/2051-1426-2-S3-P234 PMCID: PMC4292513
• 7: Evaluation of a novel CD20-targeted IL-15 immunotherapeutic with potent activity against B cell lymphoma Bai Liu, Lin Kong, Warren D Marcus, Xiaoyue Chen, Kaiping Han, Peter R Rhode, Hing C Wong J Immunother Cancer. 2014; 2(Suppl 3): P122. Published online 2014 Nov 6. doi: 10.1186/2051-1426-2-S3-P122 PMCID: PMC4288423
• 8: Novel antitumor mechanism-of-action of an IL-2 fusion protein mediated by tumor associated macrophage repolarization and innate-like CD8+ memory T cells Wenxin Xu, Jack Q Egan, Bai Liu, Xiaoyue Chen, Lijing You, Kaiping Han, Warren D Marcus, Lin Kong, Monica Jones, Emily K Jeng, Peter R Rhode, Hing C Wong J Immunother Cancer. 2014; 2(Suppl 3): P123. Published online 2014 Nov 6. doi: 10.1186/2051-1426-2-S3-P123 PMCID: PMC4288425
• 9: Enhanced efficacy of IL-15-based ALT-803 superagonist complex in combination with immune checkpoint inhibitors in hematologic and metastatic mouse tumor models Wenxin Xu, Warren D Marcus, Peter R Rhode, Hing C Wong J Immunother Cancer. 2014; 2(Suppl 3): P121. Published online 2014 Nov 6. doi: 10.1186/2051-1426-2-S3-P121 PMCID: PMC4288421
• 10: Efficacy and Mechanism-of-Action of a Novel Superagonist Interleukin-15: Interleukin-15 Receptor α/Fc Fusion Complex in Syngeneic Murine Models of Multiple Myeloma Wenxin Xu, Monica Jones, Bai Liu, Xiaoyun Zhu, C. Bryce Johnson, Ana C. Edwards, Lin Kong, Emily K. Jeng, Kaiping Han, Warren D. Marcus, Mark P. Rubinstein, Peter R. Rhode, Hing C. Wong Cancer Res. Author manuscript; available in PMC 2014 May 15.Published in final edited form as: Cancer Res. 2013 May 15; 73(10): 3075–3086. Published online 2013 May 3. doi: 10.1158/0008-5472.CAN-12-2357 PMCID: PMC3914673
• 11: IL-15/IL-15 receptor alpha superagonist complex: High-level co-expression in recombinant mammalian cells, purification and characterization Kai-ping Han, Xiaoyun Zhu, Bai Liu, Emily Jeng, Lin Kong, Jason L. Yovandich, Vinay V. Vyas, Warren D. Marcus, Pierre-Andre Chavailleaz, Christian A. Romero, Peter R. Rhode, Hing C. Wong Cytokine. Author manuscript; available in PMC 2012 Dec 1.Published in final edited form as: Cytokine. 2011 Dec; 56(3): 804–810. Published online 2011 Oct 22. doi: 10.1016/j.cyto.2011.09.028 PMCID: PMC3221918
• 12: Novel Human Interleukin-15 Agonists Xiaoyun Zhu, Warren D. Marcus, Wenxin Xu, Hyung-Il Lee, Kaiping Han, Jack Q. Egan, Jason L. Yovandich, Peter R. Rhode, Hing C. Wong J Immunol. Author manuscript; available in PMC 2010 Sep 15.Published in final edited form as: J Immunol. 2009 Sep 15; 183(6): 3598. Published online 2009 Aug 26. doi: 10.4049/jimmunol.0901244 PMCID: PMC2814526
• 13: Characterization of an antibody scFv that recognizes fibrillar insulin and beta-amyloid using atomic force microscopy. Marcus WD, Wang H, Lindsay SM, Sierks MR. Nanomedicine. 2008 Mar;4(1):1-7. doi: 10.1016/j.nano.2007.11.003. Epub 2008 Jan 16. PMID: 18201941
• 14: Identification and repair of positive binding antibodies containing randomly generated amber codons from synthetic phage display libraries. Marcus WD, Lindsay SM, Sierks MR. Biotechnol Prog. 2006 May-Jun;22(3):919-22. doi: 10.1021/bp050420y. PMID: 16739981
• 15: Isolation of an scFv targeting BRG1 using phage display with characterization by AFM. Marcus WD, Wang H, Lohr D, Sierks MR, Lindsay SM. Biochem Biophys Res Commun. 2006 Apr 21;342(4):1123-9. doi: 10.1016/j.bbrc.2006.02.073. Epub 2006 Feb 23. PMID: 16513088
• 16: Two-dimensional Kinetics Regulation of αLβ2-ICAM-1 Interaction by Conformational Changes of the αL-Inserted Domain Fang Zhang, Warren D. Marcus, Nimita H. Goyal, Periasamy Selvaraj, Timothy A. Springer, Cheng Zhu J Biol Chem. Author manuscript; available in PMC 2006 Jun 8.Published in final edited form as: J Biol Chem. 2005 Dec 23; 280(51): 42207–42218. Published online 2005 Oct 18. doi: 10.1074/jbc.M510407200 PMCID: PMC1475765
• 17: Distinct molecular and cellular contributions to stabilizing selectin-mediated rolling under flow Tadayuki Yago, Anne Leppänen, Haiying Qiu, Warren D. Marcus, Matthias U. Nollert, Cheng Zhu, Richard D. Cummings, Rodger P. McEver J Cell Biol. 2002 Aug 19; 158(4): 787–799. doi: 10.1083/jcb.200204041 PMCID: PMC2174028
• 18: Membrane tethers formed from blood cells with available area and determination of their adhesion energy. Robert M Hochmuth, Warren D Marcus Biophys J. 2002 Jun; 82(6): 2964–2969. doi: 10.1016/S0006-3495(02)75637-3 PMCID: PMC1302084
• 19: Experimental studies of membrane tethers formed from human neutrophils. Marcus WD, Hochmuth RM. Ann Biomed Eng. 2002 Nov-Dec;30(10):1273-80. doi: 10.1114/1.1528614. PMID: 12540203