Xiaoxiao Liu
Houston,TX
Summary
Motivated researcher with strong experience in clonal hematopoiesis, tumor immunology (AML/MDS, solid tumor microenviroment, cancer metastasis), and therapeutic development. Skilled in experimental design, data analysis, and scientific writing. Highly collaborative team player known for adaptability and reliability. Strong communicator with focus on achieving research goals and contributing to impactful scientific discoveries that benefits patients.
Overview
6
6
years of professional experience
Work History
CPRIT TRIUMPH Postdoc Fellow
Md Anderson Medical Cancer Center
03.2024 - Current
Appointed as a TRIUMPH Postdoctoral Fellow at MD Anderson Cancer Center to lead research on novel immunoprevention strategies targeting breast cancer and metastatic progression
Researcher
CHUGAI PHARMACEUTICAL CO., LTD. (Roche Group)
04.2022 - 03.2024
Investigated the preclinical rationale for combining bispecific T cell engagers with antibody-drug conjugates (ADCs) in the treatment of diffuse large B-cell lymphoma (DLBCL)
Visiting Scientist
Cincinnati Children’s Hospital Medical Center
05.2019 - 11.2019
Joined Dr. James Mulloy’s lab as a short-term scholar to investigate MLL-fusion acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) using patient-derived xenograft (PDX) models for therapeutic evaluation.
Education
Ph.D. - Medical Sciences
The University of Tokyo
03-2022
M.S. - Medical Sciences
The University of Tokyo
03-2018
B.S. - Pharmacology
Kyushu University
03-2016
Skills
Technically proficient in flow cytometry, CyTOF, CRISPR-based gene editing, RNA-seq, ChIP-seq Experienced in handling in vivo models, including preclinical studies using transgenic mice and patient-derived xenografts (PDX) Computational skills include data analysis and visualization using R and beginner-level Python, with a commitment to continuous learning in bioinformatics Proven ability to collaborate across multi-disciplines, project managing, and communicate findings effectively through scientific writing and presentations
Awards
- CPRIT TRIUMPH postdoc fellowship (CPRIT Training Award RP210028)
- 2023 Cancer Science Young Scientists Award
- Best Presentation Award 2021 (1st) & 2020 (3rd) at IMSUT
- 2017-2021 Program for Leading Graduate School Scholarship, The University of Tokyo, Japan Program: The Global Leader Program for Social Design and Management (GSDM)
Publications
- Naru S., Susumu G., ... Xiaoxiao Liu,...and Toshio K., Clonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity. Nature Cardiovascular Research (2024)
- Natsumi, K., Sei,S., Xiaoxiao L., Shigeki Y., Revealing the Synergistic Potential of Mosunetuzumab Plus Polatuzumab Vedotin through CD20 Upregulation. Blood abstract (2024)
- Xiaoxiao, L., Naru, S., Yuko, S., … and Susumu, G., CHIP-associated mutant ASXL1 in blood cells promotes solid tumor progression, Cancer Science, Volume 113, Issue 4, 1182-1194 (2022)
- Xiaoxiao, L., Naru, S., Tomohiro Y., … and Susumu, G., IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia, EMBO Mol Med (2022) e15631
- Moe, T., Taishi, Y., Xiaoxiao, L., …and Susumu, G., Opposing effects of acute versus chronic inhibition of p53 on decitabine’s efficacy in myeloid neoplasms, Scientific Reports 9, Article number: 8171(2019)
- Yasutaka, H., Susumu, G., Xiaoxiao, L., …and Toshio, K., Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia, Nature Communications 10, Article number: 4869 (2019)
- Taishi, Y., Hirotaka, T., Shiori, S., Xiaoxiao, L., … and Susumu, G., The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1, J Biol Chem. 292(30):12528-12541 (2017)
Languages
English
Full Professional
Japanese
Native or Bilingual
Chinese (Mandarin)
Native or Bilingual
Timeline
CPRIT TRIUMPH Postdoc Fellow
Md Anderson Medical Cancer Center
03.2024 - Current
Researcher
CHUGAI PHARMACEUTICAL CO., LTD. (Roche Group)
04.2022 - 03.2024
Visiting Scientist
Cincinnati Children’s Hospital Medical Center
05.2019 - 11.2019
Ph.D. - Medical Sciences
The University of Tokyo
M.S. - Medical Sciences
The University of Tokyo
B.S. - Pharmacology
Kyushu University
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