Xiuyuan Xiangli
Providence,Rhode Island
Summary
Highly self-motivated individual with a strong focus on cellular biology and immunology research. Skilled in multitasking, driven by a genuine passion for advancing the field of science, particularly in drug discovery. Exceptional communication and interpersonal abilities, proven ability to work independently and collaboratively.
Overview
4
4
years of professional experience
Work History
Graduate Research Assistant
Brown University
Providence, Rhode Island
08.2023 - Current
- Supervisor Name: Professor Jeffrey Morgan
- Evaluated the effect of a drug DB1976 on the expression of fibroblasts within 3D cell ring model
- Investigated the effect of TGF-Beta1 on the expression of fibroblasts within the 3D cell ring model by quantifying the X,Y, and Z images of the 3D cell ring model using ImageJ
- Used agarose gel and 24-well plates to make customized 3D cell ring models
- Quantified the expression of fibroblasts by using a great variety of assays, including measuring X,Y, and Z image, collagen content, mechanical testing, and constriction assay
- Quantified the collagen content, DNA content, and cellularity within the 3D cell ring model by performing papain digest
- Conducted Cell Passaging for 3D cell ring model
- Managed multiple research projects simultaneously, ensuring timely completion and adherence to high-quality standards.
- Contributed to professionally-written scientific paper for publication.
- Contributed to the development of research proposals, securing funding for critical projects.
Research Assistant
Case Western Reserve University
Cleveland, Ohio
09.2021 - 05.2023
- Supervisor Name: Professor William Merrick
- Investigated the role of hemoglobin mRNA as a model mRNA, and factors influencing the regulation of translation initiation in mammalian systems
- Unraveled the potential relationship between the influence of individual initiation factors on translation initiation
- Conducted in vitro cell passaging
- Used flow cytometry to measure the contents of DNA and RNA in the mRNA initiation factors, including eIF4A, eIF4B, eIF4F, and eIF4H
- Evaluated the safety and feasibility of interaction of mRNA specific initiation factors, including eIF4A, eIF4B, eIF4F, and eIF4H with RNA by utilizing cytotoxical assays
- Hosted weekly meetings within lab to discuss research progress and continued to read and analyzed mRNA-related literature
- Participated actively in regular meetings with fellow researchers to discuss project updates, challenges faced, and lessons learned during ongoing activities
- Organized research materials, maintaining a well-ordered workspace conducive to productivity
- Conducted literature reviews to support hypothesis development and identify gaps in existing knowledge.
Research Assistant
Chongqing University
Chongqing, China
02.2021 - 08.2021
- Supervisor Name: Professor Guixue Wang
- Used multifunctional fusion protein-coated heart stent to inhibit endothelial growth and inflammation after implantation
- Evaluated the effect of rapamycin as an inhibitor for smooth muscle proliferation and inflammation after heart stent implantation
- Performed cell culturing and cell viability assay
- Conducted Western Blot to measure the proliferation and viability of smooth muscle cells from arterial tissue of rats
- Aided in the process of experimental rats dissection
- In charge of feeding experimental rats and checked their conditions on a daily basis
- Responsible for recording the group meetings twice a week and summarizing the experimental literature involved
- Prepared and distributed meeting agendas, minutes, and other relevant materials while maintaining a good laboratory practice
- Maintained a safe and organized laboratory environment by adhering to best practices for chemical handling and waste disposal.
Education
Master of Science - Biotechnology
Brown University
05.2025
Bachelor of Science - Biochemistry
Case Western Reserve University
05.2023
Skills
- Mammalian Cell Culture
- Liquid Chromatography
- DNA Extraction
- PCR
- RNA Extraction
- QPCR
- SDS-PAGE
- Western Blotting
- R Studio
- Flow Cytometry
- Protein Purification
- ELISA
- Microsoft Office
- Microsoft Windows
- In Vivo Cell Culture
- In Vitro Cell Culture
- Immunofluorescence
- Analytical Thinking
Websites
Locations
Providence, Rhode Island
Training
- BIOL2260 Physiological Pharmacology
- BIOL1290 Cancer Biology
- BIOL1600 Development of Vaccines to Infectious Diseases
- CHEM311 Inorganic Chemistry
- BIOC334 Structural and Computational Biology
- BIOC312 Proteins and Enzymes
- BIOC307 Introduction to Biochemistry
- BIOC308 Molecular Biology
- MATH304 Discrete Mathematics
- CHEM336 Physical Chemistry II
- STAT313 Statistics for Experimenters
Languages
Chinese (Mandarin)
Native or Bilingual
English
Native or Bilingual
Spanish
Professional Working
Timeline
Graduate Research Assistant
Brown University
08.2023 - Current
Research Assistant
Case Western Reserve University
09.2021 - 05.2023
Research Assistant
Chongqing University
02.2021 - 08.2021
Master of Science - Biotechnology
Brown University
Bachelor of Science - Biochemistry
Case Western Reserve University