Yang Xu

I have developed a multidisciplinary background to comprehend and investigate brain function post various types of strokes. My focus lies in understanding the signal pathways in Mouse Models of Middle Cerebral Artery Occlusion (MCAO), global cerebral ischemia/reperfusion (I/R) injury, and intracerebral hemorrhage (ICH).

Following ischemic injury, the swift and effective recovery of cerebral blood vessels can salvage reversible damage to neurons and enhance functional improvement. A close interplay exists between inflammation and necroptosis after I/R injury. This understanding is crucial for establishing a foundation for effective therapeutic options to safeguard against extended neurovascular injuries. A promising therapeutic strategy for treating I/R injury involves targeting the RIP3 and neuroinflammation-mediated necroptosis signaling pathway from the cytoplasm to the nucleus.

MiRNA methylation modification emerges as a significant mechanism contributing to neuronal death after a stroke. Based on my previous research findings, the methyltransferase METTL3 and necroptosis protein RIP1/RIP3 exhibited the most significant up-regulation post-stroke. I propose delving into the RIP1/RIP3 signaling pathway mediated by miRNA methylation modification, aiming to unveil the mechanism of m6A/miRNA in regulating neuronal necroptosis.

1. Xu Y, Nowrangi D, Liang H, Wang T, Yu L, Lu T, et al. DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage. J Neuroinflammation. 2020;17(1):130. IF: 9.58

2. Qingqing Bai, Shuoyang Wang, Dongmei Rao, Zhiming Zhou, Jianfei Wang, Qi Wang, Yu Qin, Zhaohu Chu, Shoucai Zhao, Dijing Yu, Xu Y *. RIPK3 activation promotes DAXX-dependent neuronal necroptosis after intracerebral hemorrhage in mice. CNS Neurosci Ther. 2023 Aug 8;30(1): e14397. IF: 5.5

3. Qi Wang, Sifan Xu, Bin Wang, Yu Qin, Yachen Ji, Qian Yang, Xu Y *, Zhiming Zhou. Chemokine receptor 7 mediates miRNA-182 to regulate cerebral ischemia/reperfusion injury in rats. CNS Neurosci Ther. 2023 Feb;29(2):712-726. IF: 5.5

4. Ruirui Zhang, Fanfu Jin, Lanlan Zheng, Tingwei Liao, Guangling Guan, Jianfei Wang, Shoucai Zhao, Shizao Fei, Zhaohu Chu, Xu Y *.Neutrophil to High-Density Lipoprotein Ratio is Associated with Hemorrhagic Transformation in Patients with Acute Ischemic Stroke. J Inflamm Res. 2022 Nov 4:15:6073-6085. IF: 4.5

5. Hu W, Wu X, Yu D, Zhao L, Zhu X, Li X, Huang T, Chu Z, Xu Y *. Regulation of JNK signaling pathway and RIPK3/AIF in necroptosis-mediated global cerebral ischemia/reperfusion injury in rats. Exp Neurol. 2020;331:113374. IF: 5.33

6. Luan D, Zhang Y, Yuan L, Chu Z, Ma L, Xu Y * et al. MST4 modulates the neuro-inflammatory response by regulating IkappaBalpha signaling pathway and affects the early outcome of experimental ischemic stroke in mice. Brain Res Bull. 2020;154:43-50. IF: 4.077

7. Wu X, Zhang Y, Zhang Y, Xia L, Yang Y, Wang P, Xu Y *, Ren Z, Liu H. MST4 attenuates NLRP3 inflammasome-mediated neuroinflammation and affects the prognosis after intracerebral hemorrhage in mice. Brain Res Bull. 2021 Dec;177:31-38. IF:4.077

8. Jianfei Wang 1 2, Wenjie Hu 3, Ruirui Zhang 2, Fanfu Jin 2, Jia Hu 2, Qingqing Bai 1 2, Qi Wang 2, Shoucai Zhao 2, Zhaohu Chu 2, Yang Xu. Meningitis due to Streptococcus parasanguinis after percutaneous radiofrequency treatment for trigeminal neuralgia: A case report. Sci Prog. 2023 Apr-Jun;106(2):368504231170302.

9. Huang S, Hu W, Rao D, Wu X, Bai Q, Wang J, Chu Z, Xu Y *. RIPK3-Dependent Necroptosis Activates MCP-1-Mediated Inflammation in Mice after Intracerebral Hemorrhage. J Stroke Cerebrovasc Dis. 2022 Jan 24;31(1):106213. IF:2.1

10. Xu Y,Wu X, Hu W, Yu D, Shao Z, Li W, Huang T, Zhang J, Zhu X, Li X, Yang H, Chu Z, Lv K. RIP3 facilitates necroptosis through CaMKII and AIF after intracerebral hemorrhage in mice. Neurosci Lett. 2021:135699. IF: 3.046

11. Yang Xu,Yingying Zhou, Dijing Yu, Wenjie Hu, Xiaodong Wu, Jianfei Wang, Simei Huang, Shoucai Zhao, Xiaoli Fan, Zhaohu Chu, and Lingsong Ma. The Autophagy Signaling Pathway in Necroptosis-Dependent Cerebral Ischemia/Reperfusion Injury. Neurochemical Journal, 2021, Vol. 15, No. 3, pp. 247–253. IF: 0.46

12. Zhao SC, H X, YP W, Di L, WenQian W, Ling-Song M, Chu ZH, Xu Y *. CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke. Brain Behav. 2020 Oct 17:e01882. IF: 2.708

13. Chen Zhang, Renhui Liu, Mengmeng Chen, Yang Xu, Xiaoqin Jin, Bing Shen, Jingye Wang. Autophagy inhibitors 3-MA and BAF may attenuate hippocampal neuronal necroptosis after global cerebral ischemia-reperfusion injury in male rats by inhibiting the interaction of the RIP3/AIF/CypA complex. J Neurosci Res 2024 Feb;102(2):e25301. IF: 4.2

14. Ariel Diaz, Cynthia Martin-Jimenez, Yang Xu, Paola Merino, Yena Woo, Enrique Torre, Manuel Yepes. Urokinase-type plasminogen activator-mediated crosstalk between N-cadherin and β-catenin promotes wound healing. J Cell Sci. 2021 Jun 1;134(11):jcs255919. IF: 4.0

15. Li X, Zhang Y, Pei W, Zhang M, Yang H, Zhong M, Kong X, Xu Y, Zhu X, Chen T, Ye J, Lv K. LncRNA Dnmt3aos regulates Dnmt3a expression leading to aberrant DNA methylation in macrophage polarization. FASEB J. 2020;34(4):5077-91. IF: 5.191

16. Wu X, Wu J, Hu W, Wang Q, Liu H, Chu Z, Lv K, Xu Y *. MST4 Kinase Inhibitor Hesperadin Attenuates Autophagy and Behavioral Disorder via the MST4/AKT Pathway in Intracerebral Hemorrhage Mice. Behav Neurol. 2020;2020:2476861. IF: 3.342

17. Liang H, Matei N, McBride DW, Xu Y, Tang J, Luo B, et al. Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats. J Biomed Sci. 2020;27(1):61. IF: 8.410

18. Liang H, Matei N, McBride DW, Xu Y, Zhou Z, Tang J, Luo B, Zhang JH. TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats. J Neuroinflammation 2021 Feb 2;18(1):40. IF: 8.32

19. Zhang R, Wu X, Hu W, Zhao L, Zhao S, Zhang J, Chu Z, Xu Y*. Neutrophil-to-lymphocyte ratio predicts hemorrhagic transformation in ischemic stroke: A meta-analysis. Brain Behav. 2019;9(9):e01382. IF: 2.128

20. Lu Z, Wang Z, Yu L, Ding Y, Xu Y, Xu N, et al. GCN2 reduces inflammation by p-eIF2alpha/ATF4 pathway after intracerebral hemorrhage in mice. Exp Neurol. 2019;313:16-25. IF: 4.966

21. Lu T, Wang Z, Prativa S, Xu Y, Wang T, Zhang Y, Yu L, Xu N, Tang J, You W, Chen G, Zhang JH. Macrophage stimulating protein preserves blood brain barrier integrity after intracerebral hemorrhage through recepteur d'origine nantais dependent GAB1/Src/beta-catenin pathway activation in a mouse model. J Neurochem. 2019;148(1):114-26. IF: 4.066

22. Xu Y,Zhang J, Ma L, Zhao S, Li S, Huang T, et al. The Pathogenesis of Necroptosis-Dependent Signaling Pathway in Cerebral Ischemic Disease. Behav Neurol. 2018;2018:6814393. IF: 1.908

23. Wu X, Chen S, Li S, Zhang J, Luan D, Zhao S, Chu Z, Xu Y*. Oxygen therapy in patients with retinal artery occlusion: A meta-analysis. PLoS One. 2018;13(8):e0202154. IF: 2.776

24. Tang Z, Qin D, Tao M, Lv K, Chen S, Zhu X, Li X, Chen T, Zhang M, Zhong M, Yang H, Xu Y, Mao S. Examining the utility of the CD64 index compared with other conventional indices for early diagnosis of neonatal infection. Sci Rep. 2018;8(1):9994. IF: 4.011

25. Huang T, Xu Y, Chen Y, Bian J, Chu Z, Zhao S, Ma L. Efficacy and safety of calcitonin gene-related peptide antagonists in migraine treatment: A meta-analysis. Brain Behav. 2022 Apr;12(4):e2542. IF: 2.71

26. Ke D, Zhou F, Liang H, Xu Y, Lou H. Hypertriglyceridemia Is Associated with Reduced Leukoaraiosis Severity in Patients with a Small Vessel Stroke. Behav Neurol. 2018;2018:1361780. IF: 1.908

27. Yu L, Lu Z, Burchell S, Nowrangi D, Manaenko A, Li X, Xu Y, Xu N, Tang J, Dai H, Zhang JH. Adropin preserves the blood-brain barrier through a Notch1/Hes1 pathway after intracerebral hemorrhage in mice. J Neurochem. 2017;143(6):750-60. IF: 4.609

28. Xu Y,Wang J, Song X, Wei R, He F, Peng G, et al. Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats. Brain Res Bull. 2016;120:97-105. IF: 3.033

29. Xu Y,Wang J, Song X, Qu L, Wei R, He F, et al. RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF. Sci Rep. 2016;6:29362. IF: 4.529

30. Xu Y,Ji R, Wei R, Yin B, He F, Luo B. The Efficacy of Hyperbaric Oxygen Therapy on Middle Cerebral Artery Occlusion in Animal Studies: A Meta-Analysis. PLoS One. 2016;11(2):e0148324. IF: 2.806

31. Yin B, Xu Y, Wei RL, He F, Luo BY, Wang JY. Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury. Brain Res. 2015;1609:63-71. IF: 3.002

32. Wei R, Wang J, Xu Y, Yin B, He F, Du Y, et al. Probenecid protects against cerebral ischemia/reperfusion injury by inhibiting lysosomal and inflammatory damage in rats. Neuroscience. 2015;301:168-77. IF: 3.231

33. Yin B, Xu Y (Co-first Author), Wei R, Luo B. Ginkgo biloba on focal cerebral ischemia: a systematic review and meta-analysis. Am J Chin Med. 2014;42(4):769-83. IF: 2.959

34. Wei RL, Teng HJ, Yin B, Xu Y, Du Y, He FP, et al. A systematic review and meta-analysis of buyang huanwu decoction in animal model of focal cerebral ischemia. Evid Based Complement Alternat Med. 2013;2013:138484. IF: 2.716