YAHUI LI

Over the past six years, I have advanced my research on the lymphatic metastasis mechanism of esophageal squamous cell carcinoma (ESCC) and discovered the crucial role of the Nrf2 molecular signaling pathway in this process. My work at the Cooper University Health Care and Julius L. Chambers Biomedical Biotechnology Research Institute and the Biomanufacturing Research Institute and Technology Enterprise included significant contributions to studies on NOTCH-PAX9 signaling and NRF2 inhibitors in cancer, resulting in 10 publications. Mentoring students in our lab has enriched my research perspective and strengthened my passion for teaching.

• Histopathology: handling tissue samples for frozen and paraffin sectioning, histochemical staining, immunohistochemical staining, immunofluorescence staining, whole organ immunostaining for light sheet microscopy
• Cell culture, stable transfection, siRNA knockdown
• Protein quantitation, Western blotting
• Animal breeding, colony maintenance, and genotyping
• Mouse basic operation (Oral gavage, intraperitoneal injection, subcutaneous injection, tail vain injection, transcardial perfusion to fix whole mouse)
• Survival surgery on the mouse esophagus
• Imaging procedures: IVIS (Perkin Elmer), confocal microscope (Zeiss, Nikon, Olympus), light and fluorescent microscope (Keyence), and Mantra quantitative pathology workstation (Akoya), light-sheet microscopy

• Microsoft Office
• Photoshop
• Graphpad
• Image J
• Endnote, etc.
• Proficient in statistical analysis of experimental data

• Lymphatic drainage system and lymphatic metastasis of cancer cell in the mouse esophagus, Digestive Diseases and Sciences, 2023, 68.3, 803-812, Li Y, Cheng Q, Xiong Z, Paiboonrungruang C, Adekoya TO, Li Y, Chen X
• Notch and esophageal squamous cell carcinoma, Adv Exp Med Biol, 2021, 1287, 59-68, Li Y, Li Y, Chen X
• Host versus cell-dependent effects of β-arrestin 1 expression in prostate tumorigenesis, Carcinogenesis, 2021, 42, 772-83, Adekoya TO, Smith N, Thomas AJ, Lane TS, Burnette N, Rivers EJ, Li Y, Chen X, Richardson RM
• Knockdown of microRNA-214-3p Promotes Tumor Growth and Epithelial-Mesenchymal Transition in Prostate Cancer, Cancers, 2021, 13, 5875, Cagle P, Smith N, Adekoya TO, Li Y, Kim S, Rios-Colon L, Deep G, Niture S, Albanese C, Suy S, Collins SP, Kumar D
• Development of targeted therapy of NRF2high esophageal squamous cell carcinoma, Cell Signal, 2021, 86, 110105, Paiboonrungruang C, Simpson E, Xiong Z, Huang C, Li J, Li Y, Chen X
• Alcohol drinking inhibits NOTCH-PAX9 signaling in esophageal squamous epithelial cells, J Pathol, 2021, 253, 384-395, Shi M, Ren S, Chen H, Li J, Huang C, Li Y, Han Y, Li Y, Sun Z, Chen X, Xiong Z
• PAX9 in Cancer Development, International Journal of Molecular Sciences, 2022, 23.10, 5589, Chen X, Li Y, Paiboonrungruang C, Li Y, Peters H, Kist R, Xiong Z
• Exploring Cell Competition for the Prevention and Therapy of Esophageal Squamous Cell Carcinoma, Biochemical Pharmacology, 2023, 115639, Knapp K, Verchio V, Coburn-Flynn O, Li Y, Xiong Z, Morrison JC, Shersher DD, Spitz F, Chen X
• Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasia, Redox Biology, 2023, 102901, Paiboonrungruang C, Xiong Z, Lamson D, Li Y, Bowman B, Chembo J, Huang C, Li J, Livingston EW, Frank JE, Chen V
• Pancreatic Neuroendocrine Tumors: Signaling Pathways and Epigenetic Regulation, International Journal of Molecular Sciences, 2024, 25, 2, 1331, Saleh Z, Moccia MC, Ladd Z, Joneja U, Li Y, Spitz F, Hong YK, Gao T