Accomplished Research Associate from Johns Hopkins University, adept in biochemistry techniques like qPCR and proficient in scientific writing. Excelled in advancing research projects to completion, exceeding quality standards, and mentoring students, significantly enhancing organizational visibility. Demonstrated expertise in clinical research and drug screening, contributing to groundbreaking findings in mouse model studies.
1. Yang Li , Yuhan Fu, Xinshu Zhang, Mei Wan, Junying Zheng, Xu Cao. Elevated TGF-β induces phosphorylation of gap junction Cx43 to generate hypoxia-TGF-β vicious cycle as a therapeutic target for stroke. ( submitted ).
2. Yang Li , Shuting Yang, Shuying Yang*. IFT20 and TAZ synchronously regulate bone homeostasis by modulating TGF-β receptor 2 signaling. 2024. ( submitted ).
3. Yang Li , Shuting Yang, Shuying Yang*. Deficiency of Trp53 and Rb1 in myeloid cell lineage spontaneously develops acute myeloid leukemia in mouse model. 2024. Genes & Disease .
4. Yang Li , Shuting Yang, Shuying Yang*. Trp53 controls chondrogenesis and endochondral ossification by negative regulation of TAZ activity and stability via β-TrCP-mediated ubiquitination. 2022. Cell Death Discovery .
5. Yang Li , Shuting Yang, Yang Liu, Shuying Yang*. Trp53 and Rb1 deficiency in chondrocytes spontaneously develop chondrosarcoma by activation of YAP signaling. 2022. Cell Death & Disease .
6. Yang Li , Shuting Yang, Shuying Yang*. Rb1 negatively regulates bone formation and remodeling through inhibiting transcriptional regulation of YAP in Glut1 and OPG expression and glucose metabolism in male mice. 2022. Molecular Metabolism .
7. Yang Li , Shuting Yang, Yang Liu, Ling Qin, Shuying Yang*. IFT20 govern mesenchymal stem cell fate through positively regulating TGF-β-Smad2/3-Glut1 signaling mediated glucose metabolism. 2022. Redox Biology .
8. Yang Li , Shuting Yang, Yang Liu, Shuying Yang*. Deletion of Trp53 and Rb1 in Ctsk-expressing cells drives osteosarcoma progression by activating glucose metabolism and YAP signaling. 2022. Medcomm .
9. Yang Li , Shuting Yang, Shuying Yang*. Verteporfin Inhibits the Progression of Spontaneous Osteosarcoma Caused by Trp53 and Rb1 Deficiency in Ctsk-Expressing Cells via Impeding Hippo Pathway. 2022. Cells .
10. Yang Li , Min Liu, Shuting Yang, Ashley M. Fuller, T. S. Karin Eisinger, Shuying Yang*. RGS12 is a novel tumor suppressor in osteosarcoma that inhibits YAP-TEAD1-Ezrin signaling. 2021. Oncogene .
11. Yang Li , Shuting Yang, Ling Qin, Shuying Yang*. TAZ is required for chondrogenesis and skeletal development. 2021. Cell Discovery .
12. Yang Li , Nan Hu, Dan Yang, Gregory Oxenkrug and Qing Yang*. Regulating the balance between the kynurenine and serotonin pathways of tryptophan metabolism. 2017. FEBS J .
13. Guiying Jin#, Yang Li #, Yuwen Zhu, Lisha Du, Junkai Yan and Qing Yang*. SMS regulates the expression and function of P-gp and MRP2 in Caco-2 cells. 2016. Cell Biology and Toxicology .
14. Yang Li , YuSong Lin, YongBing Li, BaoShan Chen, Ru Li*. Functional study of RasGAP gene in chestnut blight fungus. 2019. Genomics and Applied Biology .