Yunyao Xu

Expert in solid- and solution-state NMR techniques 10+ years of wet-lab experience working on protein Extensive experience in structural characterization of proteins, including membrane proteins and protein aggregates by NMR and CryoEM Proficient in MD simulation and its applications in biological problems Additional skills: computational chemistry (DFT); machine learning

• Ferguson Fellowship, Columbia University, 2014
• Dean’s Fellowship, Columbia University, 2012-2013
• Excellent Graduate Award in Hunan Province, awarded to 3/197 in Department of Chemistry and Chemical Engineering, Hunan University, 2011
• Zhong Yuanyu Scholarship, awarded to top 2 students in Lida Honors Class with distinguished academic achievement, Hunan University, 2008
• Academic Excellence Scholarships, Hunan University, 2008-2011

• Y. Xu, M. Mompeán, M. Kopylov, A. McDermott. Investigating the Three-Dimensional Structure of Amyloid Fibrils Formed by the C-Terminal Domain of TDP-43, in preparation.
• Y. Xu, L. Zhang, M. Greenberg, I. Sergevey, A. Beecher, J. Owen, R. A. Friesner, A. E. McDermott, Unraveling Structural Changes from Nanocluster to Quantum Dots using SSNMR, in preparation.
• Y. Xu, L. Zhang, R. A. Friesner, A. E. McDermott. Exploring KcsA Selective Filter Conformational Plasticity at Cryogenic Temperatures, in preparation.
• Y. Xu, A. Bartholomew, S. He, M. L. Steigerwald, X. Roy, A. E. McDermott. Probing Chemical Reaction in a Superatomic Solid, in preparation.
• X.Yi, R. Rogwaski, Y. Xu, A. McDermott. Contribution of Protein Conformational Heterogeneity to NMR Lineshape at Cryogenic Temperature. PNAS, 2024, 121, e2301053120.
• Y. Xu, J. Chen, A. P. Aydt, L. Zhang, I. Sergeyev, E. Keeler, B. Choi, S. He, D. R. Reichman, R. A. Friesner, M. Steigerwald, X. Roy, A. E. McDermott. Electron/Spin Delocalization in [Co6Se8(PEt3)6]0/+1 Superatoms. ChemPhysChem. 2024, 25, e202300064.
• Z. Jin, Q. Cheng, S. Bao, R. Zhang, A. M. Evans, F. Ng, Y. Xu, M. L. Steigerwald, A. E. McDermott, Y. Yang, C. Nuckolls. Iterative Synthesis of Contorted Macromolecular Ladders for Fast-Charging and Long-Life Lithium Batteries. J. Am. Chem. Soc. 2022, 144, 13973.
• L. Yang, C. Catalano, Y. Xu, W. Qiu, D. Zhang, A. E. McDermott, Y. Guo, P. Blount. A Native Cell Membrane Nanoparticles System Allows for High-quality Functional Proteoliposome Reconstitution. BBA Advances, 2021, 1, 10001.
• Z. Sun, Y. Xu, D. Zhang, A. E. McDermott. Probing Allosteric Coupling of a Constitutively Open Mutant of the Ion Channel KcsA using Solid State NMR. PNAS 2020, 117, 7171.
• Y. Xu, D. Zhang, R. Rogwaski, C. Nimigean, A. E. McDermott. Coupled Clusters of Allostery Participants: Identification by Chemical Shift. PNAS 2019, 116, 2078.
• Y. Xu, A. E. McDermott. Inactivation in the Potassium Channel KcsA. J. Struct. Biol. X. 2019, 3, 100009.
• Y. Xu, M. Bhate, A. E. McDermott. Transmembrane Allosteric Energetics Characterization for Strong Coupling between Proton and Potassium ion Binding in the KcsA Channel. PNAS 2017, 114, 8788.
• M. Mompeán, R. Hervás, Y. Xu, T. H. Tran, C. Guarnaccia, E. Buratti, F. Baralle, L. Tong, M. C. Vázquez, A. E. McDermott, D. V. Laurents. Structural Evidence of Amyloid Fibril Formation in the Putative Aggregation Domain of TDP-43. J. Phys. Chem. Lett. 2015, 6, 2608.
• Y. Xu, L. Deng, H. Wang, X. Ouyang, J. Zheng, J. Li, and R. Yang. Metal-induced Aggregation of Mononucleotides-stabilized Gold Nanoparticles: an Efficient Approach for Simple and Rapid Colorimetric Detection of Hg(II). Chem. Comm., 2011, 47, 6039.