Christopher Lawrence De Jesus
Brooklyn,NY
Summary
Experienced bioanalytical and quality scientist with over a decade of success in LC-MS/MS method development, stability program support, and translational pharmacology. Proven expertise in managing QC documentation, stability studies, and regulated bioanalysis under FDA and ICH guidelines. Skilled in interpreting chromatographic data, leading assay validations, and collaborating with CDMOs/CTLs. Demonstrated capability in maintaining critical reagents, authoring regulatory reports, and supporting clinical-stage programs for biologics and small molecules.
Overview
25
25
years of professional experience
1
1
Certification
Work History
Assistant Research Scientist
NEW YORK UNIVERSITY GROSSMAN SCHOOL OF MEDICINE
New York, NY
07.2019 - Current
- Lead LC-MS/MS method development and validation for pharmacokinetic, metabolomics, and regulated bioanalytical applications in translational research.
- Design and execute stability studies in accordance with FDA and ICH guidelines, supporting quality control, method robustness, and regulatory documentation.
- Analyze time-course data and perform bioanalytical data processing to inform PK/PD modeling and noncompartmental analysis.
- Collaborate across teams (biostatistics, clinical, QA) to deliver model-informed drug development (MIDD) insights and dose optimization strategies.
- Author and review SOPs, validation reports, and QC/change control documentation, and coordinate method transfers with external labs and collaborators.
- Support IND-enabling studies and preclinical trial design by contributing validated assay data for regulatory and scientific reporting.
- Actively advancing training in Population PK Modeling using Phoenix NLME and quantitative systems pharmacology (QSP) frameworks.
Laboratory Technologist
COLUMBIA UNIVERSITY IRVING MEDICAL CENTER
New York, NY
04.2017 - 06.2019
- Quantified patient drug levels to support therapeutic drug monitoring (TDM) and PK interpretation.
- Applied compartmental PK principles in the development and validation of LC-MS/MS assays for clinical use.
- Developed and validated bioanalytical methods for drugs such as Etonogestrel, Voriconazole, and Posaconazole, using Agilent 6490 and Waters Xevo TQD platforms.
- Conducted weekly system suitability checks and ensured compliance with lab QA/QC protocols.
- Supported dose optimization strategies through validated bioanalytical workflows.
- Participated in proficiency testing tracking and New York State laboratory inspection readiness.
- Reported monthly test volume data for billing and business office coordination.
- Assisted in the oversight of the quality assurance program, including review and implementation of commercial calibrators and QC materials.
- Led the complete development and SOP documentation of an LC-MS/MS assay for Etonogestrel in human serum.
- Optimized a simultaneous assay for Voriconazole and Posaconazole quantification in serum.
- Demonstrated technical competency in LC-MS/MS and HPLC-UV for the following assays: Voriconazole, Posaconazole, Everolimus, Imatinib, Busulfan, Etonogestrel, and Iothalamate (serum/urine).
- Designed and validated an LC-MS/MS Urine Drug Toxicology Panel for drugs of abuse.
- Verified absence of Acetaminophen interference in Iothalamate HPLC-UV/VIS analysis.
Medical Laboratory Staff (Mass Spectrometry / Toxicology)
LENCO LABORATORIES, INC.
Brooklyn, NY
10.2016 - 04.2019
- Supported applied pharmacokinetic (PK) analyses of drugs in urine through bioanalytical sample preparation and processing.
- Assisted licensed Medical Laboratory Technologists and the Lead Toxicologist in the confirmation of drugs of abuse (e.g., THC, Barbiturates) using LC-MS/MS.
- Supported quantification of serum vitamins C, A, and E using HPLC-UV methodology.
- Conducted sample preparation for drug of abuse panels using automated TECAN systems, improving efficiency and consistency.
- Performed daily checks on calibration curves, quality controls, and LC-MS/MS instrumentation to ensure assay readiness and data integrity.
- Assisted with routine instrument maintenance, reagent preparation, extractions, and other general lab operations in a regulated toxicology lab environment.
Mass Spectrometry Data Analyst and R&D Scientist
ADVANCED CLINICAL LABORATORY SERVICES, INC.
Brooklyn, NY
02.2016 - 10.2016
- Analyzed quantitative mass spectrometry data for pharmacokinetic (PK) interpretation to support medical decision-making in pain management and clinical toxicology.
- Supported urine drug monitoring (UDM) and oral fluid testing (OFT) workflows used for compliance evaluation in clinical settings.
- Reviewed calibration curves and quality control data to ensure analytical accuracy and regulatory alignment prior to reporting.
- Performed pre-evaluation of mass spectral data by assessing chromatographic parameters and correlating drug/metabolite patterns to aid Certifying Scientist interpretation.
- Ensured accurate detection of prescribed, illicit, and interfering substances through advanced LC-MS/MS data analysis and critical review processes.
Adjunct Lecturer
FLORIDA INTERNATIONAL UNIVERSITY
Miami, FL
08.2015 - 12.2015
- Taught undergraduate laboratory sections (18-20 students) in General Chemistry, Chemistry & Society and Human Biology.
- Provided consultation and office hours/tutoring with students.
Graduate Research Assistant
FLORIDA INTERNATIONAL UNIVERSITY
Miami, FL
04.2015 - 08.2015
- Conducted comparative evaluation of Ochratoxin A using: ELISA, HPLC-Fluorescence and Photo-Diode Array Detection, LC-MS/MS techniques for method comparison and sensitivity analysis.
- Gained hands-on experience working with human cell lines to assess toxicological effects of Microcystin A, contributing to cellular toxicity studies and environmental health assessments.
- Supported data generation and validation for toxicant exposure studies with relevance to public health and environmental toxicology.
Graduate Teaching Assistant
FLORIDA INTERNATIONAL UNIVERSITY
Miami, FL
08.2010 - 04.2015
- Taught undergraduate laboratory sections (15-24 students) in General Chemistry, Survey of Forensic Science, Survey of Chemistry and Interdisciplinary Sciences.
- Provided consultation and office hours/tutoring with students.
Student Intern
MIAMI-DADE MEDICAL EXAMINER DEPARTMENT
Miami, FL
05.2011 - 10.2011
- Observed basic forensic toxicology screening, procedures and chain of custody procedures as well as actual autopsy procedures and postmortem sample collection in the morgue and assisted in transferring autopsy specimens to the toxicology lab.
- Assisted forensic toxicologists in their routine analysis (e.g. screening, confirmatory, quantification) by preparing the reagents and samples for analysis, and learned how toxicological reporting/interpretation is made (including effects of postmortem drug redistribution).
Research Assistant
UNIVERSITY OF THE PHILIPPINES
Manila, Philippines
11.2006 - 09.2007
- Conducted routine drug and biomarker testing for emergency toxicology, therapeutic drug monitoring (TDM), and pre-employment drug screening (urine drug testing).
- Analyzed human blood samples using HPLC for pharmacokinetic quantification in bioavailability and bioequivalence studies.
- Performed quarterly method validation, quality assurance (QA), and quality control (QC) activities in line with laboratory standards and regulatory requirements.
- Assisted in regulatory compliance monitoring and contributed to SOP development and revision to ensure consistent laboratory practices.
- Maintained and updated chemical inventory systems, supporting operational readiness and safe lab practices in a high-throughput environment.
Student Intern
PHILIPPINE NUCLEAR RESEARCH INSTITUTE
Quezon City, Philippines
06.2000 - 05.2001
- Assisted in processing of environmental samples which included acid digestion and preparation for isotopic labeling by the nuclear chemists.
Education
Ph.D. - Quantum Computing
Capitol Technology University
Laurel, Maryland, USA08-2024
Master of Business Administration - Data Analytics
Louisiana State University
Shreveport, Louisiana, USA05-2021
Master of Science - Forensic Science
Florida International University
Miami, Florida, USA12-2015
Bachelor of Science - Biochemistry
University of the Philippines
Manila, Philippines01.2006
Skills
- LC-MS/MS and HPLC
- Method development and validation
- Metabolomics expertise
- Regulatory compliance guidance
- Quality assurance and management
- Data analytics and statistical analysis
- Machine learning techniques
- Python programming
- SPSS and Tableau proficiency
- Microsoft Office Suite skills
Certification
- Hawaii State Licensure as Clinical Laboratory Specialist in Clinical Chemistry
- California State Licensure as Clinical Toxicologist Scientist
- American Society for Clinical Pathology Certification as Specialist in Chemistry
- National Registry of Certified Chemists Certification as Toxicological Technologist
- American Society for Quality Certification as Quality Improvement Associate
Professional Organizations
American Society for Clinical Pathology
Educational Grants
Opportunity Grant Awardee, Philippine-American Educational Foundation (Fulbright), U.S. Department of State – Education USA, 2010
Publications
- Canagliflozin-induced adaptive metabolism in bone, Poudel SB, Chlebek C, Ruff RR, He Z, Xu F, Yildirim G, Hu B, De Jesus CL, Shinde AR, Nayak VV, Witek L, Bromage T, Neubert TA, Rosen CJ, Yakar S., Diabetes, 02/11/25, 10.2337/db24-0955, 39932694
- Functionally distinct pericyte subsets differently regulate amyloid-β deposition in patients with Alzheimer's disease, Bohannon DG, Long D, Okhravi HR, Lee SC, De Jesus CL, Neubert TA, et al., Brain Pathology, 2024, 10.1111/bpa.13282
- High Incidence and Levels of Ochratoxin A in Wines Sourced from the United States, Christopher Lawrence De Jesus, Amanda Bartley, Aaron Welch and John Berry, Toxins, 2018, 10, 1, 10.3390/toxins10010001
- Teratogenicity of Ochratoxin A and its Presumptive Degradation Product, Ochratoxin-α, in the Zebrafish (Daniorerio) Embryo Model of Vertebrate Development, Mehreen Haq, Nelson Gonzales, Keenan Mintz, Asha Jaja-Chimedza, Christopher De Jesus, Christina Lydon, Aaron Welch and John Berry, Toxins, 2016, 8, 2, 10.3390/toxins8020040
Professional Development Courses
- Certara University Course 101-OD-CERT: Intro to Population Modeling Using Phoenix NLME, ongoing
- AI and Machine Learning Course, New York University School of Professional Studies, Summer 2024
- Certificate in Data Visualization, New York University School of Professional Studies, 05/2023
- Team Member Leadership and Development Program (TLDP), NYU Langone Academy, 06/2023
- Introduction to Python Course, New York University School of Professional Studies, Summer 2021
- Introduction to IBM Quantum Computing, The Coding School, 2021
- Professional Introductory R Statistics Certificate, Harvard University (EDX), 2019
Personal Information
Citizenship: U.S. Citizen
References
References available upon request.
Timeline
Assistant Research Scientist
NEW YORK UNIVERSITY GROSSMAN SCHOOL OF MEDICINE
07.2019 - Current
Laboratory Technologist
COLUMBIA UNIVERSITY IRVING MEDICAL CENTER
04.2017 - 06.2019
Medical Laboratory Staff (Mass Spectrometry / Toxicology)
LENCO LABORATORIES, INC.
10.2016 - 04.2019
Mass Spectrometry Data Analyst and R&D Scientist
ADVANCED CLINICAL LABORATORY SERVICES, INC.
02.2016 - 10.2016
Adjunct Lecturer
FLORIDA INTERNATIONAL UNIVERSITY
08.2015 - 12.2015
Graduate Research Assistant
FLORIDA INTERNATIONAL UNIVERSITY
04.2015 - 08.2015
Student Intern
MIAMI-DADE MEDICAL EXAMINER DEPARTMENT
05.2011 - 10.2011
Graduate Teaching Assistant
FLORIDA INTERNATIONAL UNIVERSITY
08.2010 - 04.2015
Research Assistant
UNIVERSITY OF THE PHILIPPINES
11.2006 - 09.2007
Student Intern
PHILIPPINE NUCLEAR RESEARCH INSTITUTE
06.2000 - 05.2001
Ph.D. - Quantum Computing
Capitol Technology University
Master of Business Administration - Data Analytics
Louisiana State University
Master of Science - Forensic Science
Florida International University
Bachelor of Science - Biochemistry
University of the Philippines
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