Christopher Lopez
Huntley,IL
Overview
8
8
years of professional experience
Work History
Graduate Research Assistant - Kevin Legge Lab
University of Iowa
08.2017 - Current
- Performed research to characterize host immune responses to respiratory infection and vaccination
- Instrumental in the advancement of research defining the immune repertoire and protection afforded by various formulations of a novel polyanhydride nanovaccine 'IAV-nanovax'
- Defined characteristics of cross-reactive CD8 T cells that underlie heterosubtypic immunity
- Developed and validated a 31-color flow cytometry panel to characterize populations of B and T cells in multiple tissues and sample types
Undergraduate Research Assistant - Kevin Legge Lab
University of Wisconsin - Madison
08.2016 - 07.2017
- Examined the role of ORMDL3 in regulation of ER stress and the unfolded protein response (UPR) that has been associated with non-allergic childhood asthma
- Determined mechanisms by which Rhinovirus manipulates ORMDL3 expression to facilitate cellular entry and replication
Quality Control Intern
BioTechnique, LLC
08.2016 - 03.2017
- Performed monitoring of environmental systems (surfaces, air, water) in adherence to cGMP
- Isolation and characterization of environmental contaminants
- Documentation of deviations, laboratory investigations, change control, auditing, CAPA and review and approval of controlled documents
Education
PhD Microbiology and Immunology -
University of Iowa
Iowa City, IA06.2024
Bachelor of Science Microbiology -
University of Wisconsin - Madison
Madison, WI05.2017
Skills
- Cell-based functional assays: Expert in flow cytometry (31-colors), ELISA, ELISpot, intracellular cytokine stimulation (ICS), cytotoxicity assay, neutralization assay
- General: Proficiency in cell culture (primary and cell line), virus growth and propagation, protein isolation, biologics, vaccines, drug delivery, experimental design, animal work
- Molecular biology: Proficiency in DNA/RNA extraction, RT-qPCR, gel electrophoresis, western blot
- Software: Expertise with GraphPad Prism, FlowJo, ImageJ, Microsoft Office
Publications
- Influenza A Virus Vaccination: Immunity, Protection, and Recent Advances Toward A Universal Vaccine, Vaccines (Basel), 08/03/2020, 10.3390/vaccines8030434, 32756443, PMC7565301
- Polyanhydride nanovaccine against H3N2 influenza A virus generates mucosal resident and systemic immunity promoting protection, npj Vaccines, 2024, 10.1038/s41541-024-00883-3
Timeline
Graduate Research Assistant - Kevin Legge Lab
University of Iowa
08.2017 - Current
Undergraduate Research Assistant - Kevin Legge Lab
University of Wisconsin - Madison
08.2016 - 07.2017
Quality Control Intern
BioTechnique, LLC
08.2016 - 03.2017
PhD Microbiology and Immunology -
University of Iowa
Bachelor of Science Microbiology -
University of Wisconsin - Madison
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