Christopher E. Lopez

· Performed research to characterize host immune responses to respiratory infection and vaccination

· Instrumental in the advancement of research defining the immune repertoire and protection afforded by various formulations of a novel polyanhydride nanovaccine “IAV-nanovax)

· Defined the characteristics of cross-reactive CD8 T cells that underlie heterosubtypic immunity

· Developed a 31-color flow cytometry panel to characterize populations B and T cells

· Examined the role of ORMDL3 in regulation of ER stress and the unfolded protein response (UPR) that has been associated with non-allergic childhood asthma

· Mechanisms by which Rhinovirus manipulates ORMDL3 expression to facilitate cellular entry and replication

· Performed monitoring of environmental systems (surfaces, air, water) in adherence to cGMP

· Isolation and characterization of environmental contaminants

· Documentation of deviations, laboratory investigations, change control, auditing, CAPA and review and approval of controlled documents