Abigael Kosgei

Detail-oriented team player with strong organizational skills. Ability to handle multiple projects simultaneously with a high degree of accuracy.

• Postdoctoral Research Scholar, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, Department of Biochemistry and Biopharmaceuticals, 07/2023, To Date, Characterization of E. coli Mechanosensitive Channel of Large Conductance (EcMscL)
• Graduate Research Scholar, Rice University, 6100 Main St, Houston, TX, 77005, Department of Biosciences, 08/2018, 12/2022, Structural interrogation of proteins involved in the biosynthesis of 10-membered enediyne anticancer natural products
• Graduate Research Scholar, Rice University, 6100 Main St, Houston, TX, 77005, Department of Biosciences, 08/2017, 01/2018, Flask-transfer adaptation of Enterococcus faecium to Daptomycin (DAP) resistance to understand the evolution of multidrug resistance trajectories
• Undergraduate Research Intern, University of Georgia, Athens, GA, GA, Biochemistry Department, 05/2016, 07/2016, Metabolic profile changes in CB4856 and N2 strains of C. elegans when subjected to 21 and ~6% O2 levels
• Undergraduate Research Scholar, Claflin University, 400 Magnolia St, Orangeburg, SC, 29115, Biology Department, 05/2015, 05/2016, Directed Evolution of Beta-Glucosidase A from Paenibacillus Polymyxa to Thermostability
• Undergraduate Research Scholar, Claflin University, 400 Magnolia St, Orangeburg, SC, 29115, Chemistry Department, 08/2014, 05/2015, Reactions of Cadmium (II) Iodide with Pyrimidine-2, 6-dicarboxyllate
• Undergraduate Research Intern, Iowa State University, Ames, IA, IA, Molecular Biology Department, 06/2014, 08/2014, Study of N-terminus and Transmembrane domain of MUR3 involved in xyloglucan biosynthesis

• Assistant Prayer Coordinator, Houston International SDA Church, 08/2023, To Date, Organize and oversee the church’s spiritual growth through weekly prayer meetings and daily prayer groups within the church.
• Prayer Director, Houston International SDA Church, 05/2021, 06/2023, Organize and oversee the church’s spiritual growth through weekly prayer meetings and daily prayer groups within the church.
• BioXFEL Site-Coordinator, Rice University, 05/2021, 08/2022, Led and organized the BioXFEL journal club for the interns and ensured that they were getting well mentored in their various labs.
• Communication Director, Houston International SDA Church, 05/2019, 08/2021, Relayed all the information related to the church via emails and church bulletins to keep the members informed.
• President, Conquerors Women Organization, 12/2015, 04/2017, Initiated the organization to reduce girl-child drop out cases from school and girl-child empowerment.
• Secretary, International Students Association, 08/2014, 08/2015, Created ways to generate funds for the organization, planned the events and managed the organization’s activities.

• BioXFEL Research Scholar, May 2021
• Rice University, Biosciences Travelling Award, December 2019
• Who’s Who American Students recipient, February 2016
• VOYA STEM scholarship recipient, July 2015-2016
• Semester of Excellence Award and President’s List, Claflin University, 2014-2017
• Alice Carson Tisdale Honors Scholarship, Claflin University, 2013-2017

• Characterization of the E. coli Mechanosensitive Channel of Large Conductance (EcMscL), Baylor College of Medicine yearly BMP/CPSB Research Conference, 03/2024
• Structural Interrogation of enzymes involved in biosynthesis of two 10-membered enediynes natural products, calicheamicin and dynemicin, Emerging Trends in Cellular and Molecular Biophysics, 11/2019/2021
• Metabolic profile changes in CB4856 and N2 strains of C. elegans when subjected to 21 and ~6% O2 levels, Annual Biomedical Research Conference for Minority Students (ABRCMS), 11/2016
• Study of N-terminus and Transmembrane domain of MUR3 involved in xyloglucan biosynthesis, Research Experience for Undergraduates (REU) summer program in University of Iowa, 08/2014

DNA cloning and purification

Protein expression and purification

X-ray crystallization

Cryo-EM: Negative staining, sample preparation,  TEM data collection and analysis, Freezing samples and data analysis

Calcium Assay

Technical writing

Software: Phenix, RELION, CryoSPARC, Coot, XtalPRED, AlphaFold2

• Organic Chemistry
• Molecular Biology
• Genetics
• Molecular Interactions
• Cell Biology
• Inorganic Chemistry
• Physical Chemistry
• Cellular Interactions
• Biochemistry
• Probability and Statistics
• Intro to Programming (JAVA)
• Structural Biology

• Prater, A., Mehta, H., Kosgei, A., Miller, W., Tran, T., Arias, C., & Shamoo, Y. (2019). Environment Shapes the Accessible Daptomycin Resistance Mechanisms in Enterococcus faecium. Antimicrobial Agents And Chemotherapy, 63(10).
• Hulgan, S., Jalan, A., Li, I., Walker, D., Miller, M., Kosgei, A., Xu, W., Phillips, G., Hartgerink, J. (2020). Covalent Capture of Collagen Triple Helices using Lysine-Aspartate and Lysine-Glutamate Pairs. Biomacromolecules, (21(9), 3772-3781).
• Kosgei, A.J., Miller, M.D., Bhardwaj, M., Xu, W., Thorson, J.S., Van Lanen, S.G., & Phillips Jr., G.N. (2022). The Crystal Structure of DynF from the Dynemicin Biosynthesis Pathway of Micromonospora chersina. Acta Cryst. F78(Pt 1), 1-7

• Research Mentor, Rice University, 6100 Main St, Houston, TX, 77005, 08/2021, 12/2022, Created a research project for a second-year undergraduate student who wanted to get research experience
• Teaching Assistant, Rice University, 6100 Main St, Houston, TX, 77005, 08/2018, 04/2019, Organized evening tutoring sessions for Physical Chemistry and Cell Biology Fall and Spring Semester
• Peer Mentor, Claflin University, 400 Magnolia St, Orangeburg, SC, 29115, 08/2016, 04/2017, Mentored a group of 30 – 40 first year undergraduate students in College Algebra
• Volunteer, Greater Faith Child Development Center, Orangeburg, SC, 29115, 08/2016, 11/2016, Helped 7 middle school students in English and Mathematics
• Tutor, Student Success Center, 400 Magnolia St, Orangeburg, SC, 29115, 10/2015, 05/2016, Tutored 10 freshman students aged 18-20 in General Chemistry, General Biology and College Algebra
• Patient Care, United Hospice (Pruitt Health), Orangeburg, SC, 29115, 01/2015, 03/2015, Filed documents of almost 500 United Hospice patients regarding the patients’ death
• Mentor, YMCA, Orangeburg, SC, 29115, 08/2013, 11/2014, Collaborated with other mentors to do after school tutoring of 45 children aged 7-14 on sciences and mathematics.