Allen Bosley

Enthusiastic team leader with unique experience in research, CMC (conception through commercialization of biologics) and regulatory matters aiming at improving patients' lives.

• Process Development and Characterization for Integrated Continuous Bioprocesses – Highlights from N-mAb, K. Brower, K. Wiltberger, C. Berdugo, A Bosley, E. Goodrich, V. Pferdeort, G. Shaefer, Biotechnology Progress, 2024
• Managing Integrated Continuous Bioprocess in Real Time: Deviations in Product Quality, G. Grampp, A. Bosley, M. Qadan, J. Schiel, A. Spasoff, P. Valax, G. Shaefer, Biotechnology Progress, 2023
• Improved Process Intermediate Stability Through the Identification and Elimination of reactive Glycation Residues- A Monoclonal Antibody Case study., A. Bosley, K. Cook, S. Lin, D. Robbins, Bioengineered, 2022
• N-mAb A Case Study to Support Development and Adoption of the Integrated Continuous Bioprocesses for Monoclonal Antibodies., 55 authors representing 22 organizations (Industry, government, and academia), National Institute for Innovation in Manufacturing Biopharmaceuticals, 2022
• Kinetic Modeling as a Tool to Understand the Influence of Cell Culture Process Parameters on the Glycation of Monoclonal Antibody Biotherapeutics, N. Agarwal, A. Mason, R. Pradhan, J. Kemper, A. Bosley, D. Serfiotis-Mitsa, J. Wang, V. Lindo, S. Ahuja, D. Hatton, J. Savery, G. Miro-Quesada, Biotechnology Progress, 2019
• CLPTM1L promotes growth and enhances aneuploidy in pancreatic cancer cells., J. Jia, A.D. Bosley, A. Thompson, J. Hoskins, A. Cheuk, I. Collins, H. Parikh, Z. Xiao, K. Ylaya, M. Dzyadyk, W. Cozen, B. Hernandez, C. Lynch, S.F. Altekruse, L. Zhang, C.J. Westlake, V.M. Factor, S.Thorgeirsson, W.Bamlet, S.M. Hewitt, J. Khan, G. Petersen, T. Andresson, L.T. Amundadottir, Cancer Research, 2014
• SIRT3 Deacetylates ATP Synthase F1 Complex Proteins in Response to Nutrient and Exercise-Induced Stress., A. Vassilopoulos, J.D. Pennington, T. Andresson, D. Rees, A.D. Bosley, I.M. Fearnley, A. Ham, C.R. Flynn, S. Hill, K.L. Rose, H. Kim, C. Deng, J. Walker, D. Gius, Antioxidants and Redox Signaling, 2013
• BRD4 Short Isoform Interacts with RRP1B, SIPA1 and Components of the LINC Complex at the Inner Face of the Nuclear Membrane., J. Alsarraj, F. Faraji, T.R. Geiger, K.R. Mattaini, M. Williams, J. Wu, N.Ha, T. Merlino, R.C. Walker, A.D. Bosley, Z. Xiao, T. Andresson, D. Esposito, N. Smithers, D. Lugo, R. Prinjha, A. Day, N.P.S. Crawford, K. Ozato, K. Gardner, K.W. Hunter, PLOS ONE, 2013
• A Role for Protein–Protein Interaction Networks in the Identification and Characterization of Potential Biomarkers., A.D. Bosley, S. Das, T. Andresson, Proteomic and Metabolomic Approaches to Biomarker Discovery (Book Chapter), 2013
• The UBIAD1 prenyltransferase links menaquinone-4 synthesis to cholesterol metabolic enzymes., M.L. Nickerson, A.D. Bosley, J.S. Weiss, B.N. Kostiha, Y. Hirota, W. Brandt, D. Esposito, S. Kinoshita, L. Wessjohann, S.G. Morham, T. Andresson, H.S. Kruth, T. Okano, M. Dean, Human Mutatation, 2013
• Comparison of strong cation exchange and SDS-PAGE fractionation for analysis of multiprotein complexes., S. Das, A.D. Bosley, Ye X, K.C. Chan, I Chu, J.E. Green, H.J. Issaq, T.D. Veenstra, T. Andresson, J Proteome Res., 2010
• A method of HIV-1 inactivation compatible with antibody based depletion of abundant proteins from plasma, A. Bosley, H. N. Marshall, Y. Badralmaa, V. Natarajan, Proteomics-Clinical Application, 2008
• A bacterial one-hybrid system for interrogating Zinc Finger-DNA interactions., S. Durai, A. D. Bosley, A.B. Abulencia, S. Chandrasegaran, M. Ostermeier, Combinatorial Chemistry and High Throughput Screening, 2006
• Mathematical expressions useful in the construction, description and evaluation of protein libraries., A. Bosley, M. Ostermeier, Biomolecular Engineering, 2005