Hi, I’m
Angela Krull MD
Draper,USA
Summary
Experienced spine and sports medicine physician of 18 years. Master diagnostician of musculoskeletal and other pain disorders with prevention and rehabilitation focused approach to injury and disease. Experience with industrial injuries, return to work documentation and legal records review. Focused on whole person approach to healing using functional medicine principles in addition to traditional medical model of care.
Overview
17
years of professional experience
1
Certificate
Work History
Alta Pain Physicians
Interventional Spine and Sports Medicine Physician
09.2024 - Current
Job overview
Provide interventional and conservative sports and spine care including thorough diagnostic workup, imaging interpretation, spinal interventions, medical pain management, functional medicine testing and personalized wellness plans and preventive musculoskeletal care.
Utah Department of Labor
Medical Panel
08.2024 - Current
Job overview
I serve as a medical expert alongside other physicians on the medical panel to assist the judge in resolving disputed worker's compensation claims. I review medical records and render independent opinions on causality and necessary medical care as well as future care considerations. Patient interviews and exams are conducted virtually.
Prime Life PLLC
Founder
05.2024 - Current
Job overview
Independent contractor providing remote and in-person medical services relating to musculoskeletal medicine, spine care, pain management, industrial medicine, functional medicine, physical medicine and rehabilitation, clinical research and medical-legal expert services
Physicians' Research Options, LLC (PRO)
Affiliated Clinical Research Investigator
01.2013 - Current
Job overview
- Principal Investigator or Sub Investigator over numerous FDA approved clinical trials.
- Entrusted with monitoring patient safety
- Accurate collection of outcomes data
- Following protocols with exactness
- Keeping impeccable records
- Reporting to study sponsors and interacting with monitors to ensure compliance with all aspects of studies
- Study participation has focused on novel treatments targeting joint or spine pain and disease as well as diseases or symptoms related to metabolic syndrome.
Advanced Spine and Pain
Sports Medicine/ Spinal Interventionalist
04.2023 - 07.2024
Job overview
- Provided ongoing interventional and medical care for patients in transition from The SMART Clinic to Advanced Spine and Pain.
The SMART Clinic
Physical Medicine and Rehabilitation Specialist/ Spinal Interventionalist
07.2007 - 04.2023
Job overview
- Co-owned and operated this private PM&R based Interventional Sports Medicine/ Spine practice, serving wide variety of needs related to injury, chronic disease, aging, pain and disability.
- Thorough diagnostic workup and interpretation using in person and telehealth encounters
- Traditional interventional treatments including epidural injections, RFA, joint injections, spinal cord stimulation, TPI, nerve blocks,
- Migraine management including botox, CGRP inhibitors, at home devices
- Medication management for chronic pain, muscles spasm, neuropathy, inflammation
- Regenerative medicine treatments including PRP, exosomes, with appropriate imaging
- Worked both as provider and independent legal expert in personal injury matters and provided industrial injury care.
- Well rounded patient guidance included personalized exercise programs, nutrition counseling, attention to lifestyle contributors and development of comprehensive rehabilitation programs to restore function, prevent injury, and delay disease progression.
- Modeled and encouraged healthy living as key to success over time
- Collaborated and effectively communicated with therapists, mental health providers, attorneys, case managers, worker's comp adjustors, employers, coaches, and other physicians
- Directed HR tasks and created positive, healthy work environment with rare employee turnover
- Dissolved this business in 2023 in conjunction with the sale of its property for the mutual benefit of the owners who remain friends.
Physician Life Care Planning, LLC
Physician Life Care Planner
01.2021 - 01.2023
Job overview
- Affiliate physician retained as medical expert
- Prepared and defended comprehensive life care plans for patients with complex injuries and disabilities.
- Interviewed and examined patients, reviewed volumes of medical records
- Created legal documents outlining patient's medical conditions and related impairments
- Detailed treatments, goods and services necessary to optimize health and quality of life over specified time interval
- Produced well researched and carefully sourced cost analysis of future medical care to assist in damages assessments
- Successfully defended each life care plan at deposition.
Education
The SMART ClinicSandy, UT
Interventional Spine/ Sports Medicine Fellowship
07.2007
University of VirginiaCharlottesville, VA
Physical Medicine & Rehabilitation Residency
06.2006
University of HawaiiHonolulu
General Surgery Internship
06.2003
University Of Utah School of MedicineSalt Lake City, UT
M.D.
05.2002
Brigham Young UniversityProvo, UT
Bachelor of Science from MIcrobiology
04.1998
Skills
- Flouroscopically Guided Procedures of Joints and Spine
- Endo Hormone Testing Genova Diagnostics
- GI Effects Stool Testing Genova Diagnostics
- Exercise Prescription
- Trigger Point Injections
- Tendon Sheath and Bursa Injections
- Disability Evaluation
- EMR Proficient Advanced MD and Triarq
- Medical Cannabis QMP
- Botox for Migraine
- PRP
- Independent Medical Examinations
- Telehealth Evaluations
- Clinical Research
- MRI Interpretation of Spine and Joints
- Medical Pain Management
Certification
- Eligible to take IFM Certification Exam November 2024
- Life Care Planning-Certified, 2022
- American Board of Physical Medicine and Rehabilitation, Recertification, 01/18/2018, 12/31/2027
- American Board of Physical Medicine and Rehabilitation, 2006
Affiliations
- Institute Of Functional Medicine, 2023-present
- North American Spine Society, 2022-2023
- American Academy of Physician Life Care Planners, 2021, 2023
- Utah Medical Association, 2008-2023
- American Board of Physical Medicine and Rehabilitation, 2003, present
- American Academy of Physical Medicine and Rehabilitation, 2003, present
Timeline
Interventional Spine and Sports Medicine Physician
Alta Pain Physicians
09.2024 - Current
Medical Panel
Utah Department of Labor
08.2024 - Current
Founder
Prime Life PLLC
05.2024 - Current
Sports Medicine/ Spinal Interventionalist
Advanced Spine and Pain
04.2023 - 07.2024
Physician Life Care Planner
Physician Life Care Planning, LLC
01.2021 - 01.2023
Affiliated Clinical Research Investigator
Physicians' Research Options, LLC (PRO)
01.2013 - Current
Physical Medicine and Rehabilitation Specialist/ Spinal Interventionalist
The SMART Clinic
07.2007 - 04.2023
- Eligible to take IFM Certification Exam November 2024
- Life Care Planning-Certified, 2022
- American Board of Physical Medicine and Rehabilitation, Recertification, 01/18/2018, 12/31/2027
- American Board of Physical Medicine and Rehabilitation, 2006
The SMART Clinic
Interventional Spine/ Sports Medicine Fellowship
University of Virginia
Physical Medicine & Rehabilitation Residency
University of Hawaii
General Surgery Internship
University Of Utah School of Medicine
M.D.
Brigham Young University
Bachelor of Science from MIcrobiology
Honors And Awards
- UVA Department of PM&R SAE-R High Score Award, 2006
- President's Citation Award, 2004 AAPMR Annual Meeting
- Phi Kappa Phi
- Cum Laude
- Full Tuition Academic Scholarship 1995-1998
Publications Presentations
- Disc progenitor cell therapy improves pain, disability, and quality of life for patients with lumbar disc degeneration: results of an FDA-approved clinical trial, The Spine Journal, 22, 9, S20-S21, 2022, https://doi.org/10.1016/j.spinee.2022.06.054
- Lumbar Facet Cyst Removal Using Minimally Invasive Endoscopy: A Case Report, American Academy of Physical Medicine and Rehabilitation Annual Convention, Boston, MA, September 19, 2007, Archives of Physical Medicine and Rehabilitation 2007
- Exercise associated muscle cramps: the effects of IV rehydration on serum electrolytes, creatine kinase, fluid balance, and substrate metabolism, South East American College of Sports Medicine, Charlotte, NC, February 8-10, 2007
- Demographics and epidemiology of golf-related head trauma, American Academy of Physical Medicine and Rehabilitation Annual Convention, Phoenix, AZ, October 8, 2004, Archives of Physical Medicine and Rehabilitation
- Outcome after hip fracture in patients with dementia: A pilot study, American Academy of Physical Medicine and Rehabilitation Annual Convention, Phoenix, AZ, October 8, 2004, Archives of Physical Medicine and Rehabilitation
- Higher Hemoglobin levels appear to correlate with a greater rate of functional recovery after total knee arthroplasty, American Academy of Physical Medicine and Rehabilitation Annual Convention, Phoenix, AZ, October 8, 2004, Archives of Physical Medicine and Rehabilitation
- Traditional Tongan Cures for Morning Sickness and Their Mutagenic/Toxicological Evaluations, J. Ethnopharmocol., 71, 201-209, 2000
- Wilderness Dermatology, AWLS certification, Snowmass CO, July 2006
- Wound and Burn Management: Common Skin Injuries, University of Utah, Salt Lake City, UT, April 2005
- Hiking Medicine, University of Utah, Salt Lake City, UT, April 2005
- Osteoporosis Prevention and Treatment, University of Virginia Cardiac Rehabilitation Center, Charlottesville, VA, 2004
Clinical Research Experience
- Pfizer Good Clinical Practice w/ICH Component current
- NIH Human Subjects Research Training –current
2013: A Prospective, Randomized, Controlled Pivotal Clinical Investigation of the XXXX® Spinal Stabilization System in Patients with Lumbar Degenerative Disc Disease
2013: A Pivotal, Multi-Center, Double-Blind Study of the Safety and Effectiveness of XXX (XX) in Patients with Mild to Moderate Osteoarthritis of the Hip
2012-2013: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study To Evaluate The Efficacy And Safety Of XXX In Subjects With Neuropathic Pain From Lumbosacral Radiculopathy
2013: A Multicenter, Randomized, Double-blind, Controlled, Comparative Study of
XXX in Patients with Lumbar Disc Herniation (Phase III)
2014: A Randomized, Double-blind, Placebo-controlled, Multi-dose Phase 2 Study Evaluating the Safety and Efficacy of Intra-articular Injections of XXX in Subjects with Mild to Moderate Patello-Femoral Osteoarthritis Involving Both Knees
2015: A Randomized, Double-Blind, Multi-Dose, Placebo-Controlled Study to
Evaluate the Efficacy and Safety of XXX in Patients with Pain due to Osteoarthritis of the Knee or Hip
2015: MSB-DR003: A Prospective, Multicenter, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Single Injection of XXXX Alone or Combined with Hyaluronic Acid (HA) in Subjects with Chronic Discogenic Lumbar Back Pain Through 12 Months
Amended to: MSB-DR003: A Prospective, Multicenter, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Single Injection of XXX Alone or Combined with Hyaluronic Acid (HA) in Subjects with Chronic Low Back Pain
2015: A Multicenter, Open-label study of XXX in Patients with Lumbar Disc Herniation (Phase III) Protocol number: 6603-1132 (217079)
2015-16: A Multicenter, Non-Treatment, Follow-up Study to Assess the Health Economic Outcomes of Previous Pulsed Electromagnetic Field (PEMF) Therapy in the Treatment of Persistent Post-Operative Pain Following Lumbar Surgery #RBI.2015.001B
2016: A Phase 3, Randomized, Double Blind, Placebo And Active Controlled, Multicenter, Parallel Group Study Of The Analgesic Efficacy And Safety Of XXX In Adult Subjects With Chronic Low Back Pain #A4091059
2016 HS-16-555: A Phase III, Randomized, Double-Blind, Placebo-Controlled, Enriched-Enrollment Withdrawal, Multicenter Study to Evaluate the Efficacy and Safety of a Long-Acting Subcutaneous Injectable Depot of XXX (XX) in Subjects with a Recent History of Moderate to Severe Chronic Low Back Pain Currently Treated with Opioids
2018: TO START: Protocol TGC12301: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Phase 3 Study to Determine the Efficacy of XXX in Subjects with Kellgren and Lawrence Grade 2 or 3 Osteoarthritis of the Knee
2018: DGX-A01: A Prospective, Randomized, Double-Blinded, Vehicle-and Placebo-Controlled, Multicenter Study to Evaluate the Safety and Preliminary Efficacy of XXX in Subjects with Single-Level, Symptomatic Lumbar Intervertebral Disc Degeneration
2019: SM04690-OA-11 A Phase 3, 56-Week, Multicenter, Randomized, Double-Blind, Vehicle-Controlled Study Utilizing Patient Reported and Radiographic Outcomes to Evaluate the Efficacy and Safety of a Single Injection of XXX Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects
2019: Corticosteroid Lumbar Epidural Analgesia for Radiculopathy (C.L.E.A.R.)
2019- SM04690-OA-10 A Phase 3, 28-Week, Multicenter, Randomized, Double-Blind,
Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Single Injection of XXX Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects
2020-SM04690-OA-07 A 48-Week, Placebo-Controlled, Single Blind Extension Study
Evaluating the Safety and Efficacy of XXX in Subjects with Osteoarthritis of the Knee
2020 - A Phase 3, 14-Day, Double-blind, Randomized, Placebo-Controlled, Multicenter
Study of the Efficacy and Safety of XXX 100 mg and 200 mg TID in Subjects with Pain Due to Acute Back Muscle Spasm
2020 to- An Open-Label, Single Ascending Dose Study to Assess the Safety and
Tolerability of XXX in Patients with Osteoarthritis of the Knee
2019-2022 A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel-
Group, Dose-Ranging Study to Evaluate the Efficacy and Safety of 3 Doses of XXX as
Compared to Placebo After 12 Weeks of Treatment in Patients with Treatment-Resistant
Hypertension (rHTN)
2022: Protocol TGC12301: A Randomized, Double-Blind, Placebo-Controlled, Multi-
Center, Phase 3 Study to Determine the Efficacy of XXX in Subjects with Kellgren and
Lawrence Grade 2 or 3 Osteoarthritis of the Knee (previously on hold since 2018)
2022: A Phase 2, Randomized, Double-blind, Placebo-controlled, Parallel Group,
Multicenter Study to Evaluate the Safety and Efficacy of XXX in Subjects with
Moderate to Severe Acute Lower Back Pain
2022: RTX-OAK-201 A Phase 2, Randomized, Active and Placebo-Controlled,
Dose-Ranging Study to Evaluate the Efficacy and Safety of Intra-Articular XXXX to
Treat Moderate to Severe Pain from Knee Osteoarthritis (RTX-OAK-201)
2023: as PI: Sciatica Epidural Radiculopathy Experimental New Interventional
TherapY Clonidine Micropellet
2024: Start as Sub-I: Protocol I8F-MC-GPGN(a) The Effect of XXXXX versus XXXXX on Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes (SURPASS-CVOT) Angela Krull, MD/Study Listing (04/16/2024)
2024: Start as Sub-I: A Phase 3, Randomized, Double-Blind Study to Investigate the
Efficacy and Safety of Once- Daily Oral XXXXX Compared with Placebo in Adult
Participants with Obesity or Overweight with Weight-Related Comorbidities (ATTAIN-1). Protocol: J2A-MC-GZGP
2024: Start as Sub-I: A Phase 3, Randomized, Double-Blind, Parallel-Group, Event- Driven, Cardiovascular Safety Study with BI XXXXX Administered Subcutaneously Compared with Placebo in Participants with Overweight or Obesity with Established Cardiovascular Disease (CVD) or Chronic Kidney Disease, And/or at Least Two Weight- Related Complications or Risk Factors for CVD.
2024: Start as PI: A Randomized, Double-Blind, Single Ascending Dose Phase 1 Study of XXXX Intra-Articular Injection for Subjects with Mild to Moderate Osteoarthritis of the Knee
2024: Start as PI: A Phase 3, Multicenter, Randomized, Double-blind, Single-dose Study to Evaluate the Efficacy and Safety of XXXXX in Subjects with Glenohumeral OsteoarthritisPfizer
Training
- Immune Advanced Practice Module (IFM), March 2024
- Cardiometabolic Advanced Practice Module (IFM), January 2024
- Applying Functional Medicine in Clinical Practice APM (IFM), December 2023
- Environmental Health Advanced Practice Module (IFM), October 2023
- Gastrointestinal Advanced Practice Module (IFM), October 2023
- Bioenergetics Advanced Practice Module (IFM), August 2023
- Hormone Advanced Practice Module (IFM), July 2023
- FIG Education Life Care Planning Certification Class, June 2021
- Relievant Intracept Training and Cadaver Course, February 2021
- Vertiflex Training and Cadaver Course, December 2020
- Utah Medical Cannabis Qualified Medical Provider, March 2020
- UMA Advanced Physician Leadership Development, January 2018
- Hands-On Stem Cell Therapies and Biologics for the Clinical Application of Pain Management and Musculoskeletal Medicine, November 2017
- Buprenorphine waiver training completed, May 2015
- Utah Physician Leadership Development: Proven Skills for a New Era in Health Care, March 2015
- Regenerative Medicine Course, AAPMR annual assembly, November 2014
Honors And Awards
- UVA Department of PM&R SAE-R High Score Award, 2006
- President's Citation Award, 2004 AAPMR Annual Meeting
- Phi Kappa Phi
- Cum Laude
- Full Tuition Academic Scholarship 1995-1998
Publications Presentations
- Disc progenitor cell therapy improves pain, disability, and quality of life for patients with lumbar disc degeneration: results of an FDA-approved clinical trial, The Spine Journal, 22, 9, S20-S21, 2022, https://doi.org/10.1016/j.spinee.2022.06.054
- Lumbar Facet Cyst Removal Using Minimally Invasive Endoscopy: A Case Report, American Academy of Physical Medicine and Rehabilitation Annual Convention, Boston, MA, September 19, 2007, Archives of Physical Medicine and Rehabilitation 2007
- Exercise associated muscle cramps: the effects of IV rehydration on serum electrolytes, creatine kinase, fluid balance, and substrate metabolism, South East American College of Sports Medicine, Charlotte, NC, February 8-10, 2007
- Demographics and epidemiology of golf-related head trauma, American Academy of Physical Medicine and Rehabilitation Annual Convention, Phoenix, AZ, October 8, 2004, Archives of Physical Medicine and Rehabilitation
- Outcome after hip fracture in patients with dementia: A pilot study, American Academy of Physical Medicine and Rehabilitation Annual Convention, Phoenix, AZ, October 8, 2004, Archives of Physical Medicine and Rehabilitation
- Higher Hemoglobin levels appear to correlate with a greater rate of functional recovery after total knee arthroplasty, American Academy of Physical Medicine and Rehabilitation Annual Convention, Phoenix, AZ, October 8, 2004, Archives of Physical Medicine and Rehabilitation
- Traditional Tongan Cures for Morning Sickness and Their Mutagenic/Toxicological Evaluations, J. Ethnopharmocol., 71, 201-209, 2000
- Wilderness Dermatology, AWLS certification, Snowmass CO, July 2006
- Wound and Burn Management: Common Skin Injuries, University of Utah, Salt Lake City, UT, April 2005
- Hiking Medicine, University of Utah, Salt Lake City, UT, April 2005
- Osteoporosis Prevention and Treatment, University of Virginia Cardiac Rehabilitation Center, Charlottesville, VA, 2004
Clinical Research Experience
- Pfizer Good Clinical Practice w/ICH Component current
- NIH Human Subjects Research Training –current
2013: A Prospective, Randomized, Controlled Pivotal Clinical Investigation of the XXXX® Spinal Stabilization System in Patients with Lumbar Degenerative Disc Disease
2013: A Pivotal, Multi-Center, Double-Blind Study of the Safety and Effectiveness of XXX (XX) in Patients with Mild to Moderate Osteoarthritis of the Hip
2012-2013: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study To Evaluate The Efficacy And Safety Of XXX In Subjects With Neuropathic Pain From Lumbosacral Radiculopathy
2013: A Multicenter, Randomized, Double-blind, Controlled, Comparative Study of
XXX in Patients with Lumbar Disc Herniation (Phase III)
2014: A Randomized, Double-blind, Placebo-controlled, Multi-dose Phase 2 Study Evaluating the Safety and Efficacy of Intra-articular Injections of XXX in Subjects with Mild to Moderate Patello-Femoral Osteoarthritis Involving Both Knees
2015: A Randomized, Double-Blind, Multi-Dose, Placebo-Controlled Study to
Evaluate the Efficacy and Safety of XXX in Patients with Pain due to Osteoarthritis of the Knee or Hip
2015: MSB-DR003: A Prospective, Multicenter, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Single Injection of XXXX Alone or Combined with Hyaluronic Acid (HA) in Subjects with Chronic Discogenic Lumbar Back Pain Through 12 Months
Amended to: MSB-DR003: A Prospective, Multicenter, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Single Injection of XXX Alone or Combined with Hyaluronic Acid (HA) in Subjects with Chronic Low Back Pain
2015: A Multicenter, Open-label study of XXX in Patients with Lumbar Disc Herniation (Phase III) Protocol number: 6603-1132 (217079)
2015-16: A Multicenter, Non-Treatment, Follow-up Study to Assess the Health Economic Outcomes of Previous Pulsed Electromagnetic Field (PEMF) Therapy in the Treatment of Persistent Post-Operative Pain Following Lumbar Surgery #RBI.2015.001B
2016: A Phase 3, Randomized, Double Blind, Placebo And Active Controlled, Multicenter, Parallel Group Study Of The Analgesic Efficacy And Safety Of XXX In Adult Subjects With Chronic Low Back Pain #A4091059
2016 HS-16-555: A Phase III, Randomized, Double-Blind, Placebo-Controlled, Enriched-Enrollment Withdrawal, Multicenter Study to Evaluate the Efficacy and Safety of a Long-Acting Subcutaneous Injectable Depot of XXX (XX) in Subjects with a Recent History of Moderate to Severe Chronic Low Back Pain Currently Treated with Opioids
2018: TO START: Protocol TGC12301: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Phase 3 Study to Determine the Efficacy of XXX in Subjects with Kellgren and Lawrence Grade 2 or 3 Osteoarthritis of the Knee
2018: DGX-A01: A Prospective, Randomized, Double-Blinded, Vehicle-and Placebo-Controlled, Multicenter Study to Evaluate the Safety and Preliminary Efficacy of XXX in Subjects with Single-Level, Symptomatic Lumbar Intervertebral Disc Degeneration
2019: SM04690-OA-11 A Phase 3, 56-Week, Multicenter, Randomized, Double-Blind, Vehicle-Controlled Study Utilizing Patient Reported and Radiographic Outcomes to Evaluate the Efficacy and Safety of a Single Injection of XXX Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects
2019: Corticosteroid Lumbar Epidural Analgesia for Radiculopathy (C.L.E.A.R.)
2019- SM04690-OA-10 A Phase 3, 28-Week, Multicenter, Randomized, Double-Blind,
Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Single Injection of XXX Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects
2020-SM04690-OA-07 A 48-Week, Placebo-Controlled, Single Blind Extension Study
Evaluating the Safety and Efficacy of XXX in Subjects with Osteoarthritis of the Knee
2020 - A Phase 3, 14-Day, Double-blind, Randomized, Placebo-Controlled, Multicenter
Study of the Efficacy and Safety of XXX 100 mg and 200 mg TID in Subjects with Pain Due to Acute Back Muscle Spasm
2020 to- An Open-Label, Single Ascending Dose Study to Assess the Safety and
Tolerability of XXX in Patients with Osteoarthritis of the Knee
2019-2022 A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel-
Group, Dose-Ranging Study to Evaluate the Efficacy and Safety of 3 Doses of XXX as
Compared to Placebo After 12 Weeks of Treatment in Patients with Treatment-Resistant
Hypertension (rHTN)
2022: Protocol TGC12301: A Randomized, Double-Blind, Placebo-Controlled, Multi-
Center, Phase 3 Study to Determine the Efficacy of XXX in Subjects with Kellgren and
Lawrence Grade 2 or 3 Osteoarthritis of the Knee (previously on hold since 2018)
2022: A Phase 2, Randomized, Double-blind, Placebo-controlled, Parallel Group,
Multicenter Study to Evaluate the Safety and Efficacy of XXX in Subjects with
Moderate to Severe Acute Lower Back Pain
2022: RTX-OAK-201 A Phase 2, Randomized, Active and Placebo-Controlled,
Dose-Ranging Study to Evaluate the Efficacy and Safety of Intra-Articular XXXX to
Treat Moderate to Severe Pain from Knee Osteoarthritis (RTX-OAK-201)
2023: as PI: Sciatica Epidural Radiculopathy Experimental New Interventional
TherapY Clonidine Micropellet
2024: Start as Sub-I: Protocol I8F-MC-GPGN(a) The Effect of XXXXX versus XXXXX on Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes (SURPASS-CVOT) Angela Krull, MD/Study Listing (04/16/2024)
2024: Start as Sub-I: A Phase 3, Randomized, Double-Blind Study to Investigate the
Efficacy and Safety of Once- Daily Oral XXXXX Compared with Placebo in Adult
Participants with Obesity or Overweight with Weight-Related Comorbidities (ATTAIN-1). Protocol: J2A-MC-GZGP
2024: Start as Sub-I: A Phase 3, Randomized, Double-Blind, Parallel-Group, Event- Driven, Cardiovascular Safety Study with BI XXXXX Administered Subcutaneously Compared with Placebo in Participants with Overweight or Obesity with Established Cardiovascular Disease (CVD) or Chronic Kidney Disease, And/or at Least Two Weight- Related Complications or Risk Factors for CVD.
2024: Start as PI: A Randomized, Double-Blind, Single Ascending Dose Phase 1 Study of XXXX Intra-Articular Injection for Subjects with Mild to Moderate Osteoarthritis of the Knee
2024: Start as PI: A Phase 3, Multicenter, Randomized, Double-blind, Single-dose Study to Evaluate the Efficacy and Safety of XXXXX in Subjects with Glenohumeral OsteoarthritisPfizer
Training
- Immune Advanced Practice Module (IFM), March 2024
- Cardiometabolic Advanced Practice Module (IFM), January 2024
- Applying Functional Medicine in Clinical Practice APM (IFM), December 2023
- Environmental Health Advanced Practice Module (IFM), October 2023
- Gastrointestinal Advanced Practice Module (IFM), October 2023
- Bioenergetics Advanced Practice Module (IFM), August 2023
- Hormone Advanced Practice Module (IFM), July 2023
- FIG Education Life Care Planning Certification Class, June 2021
- Relievant Intracept Training and Cadaver Course, February 2021
- Vertiflex Training and Cadaver Course, December 2020
- Utah Medical Cannabis Qualified Medical Provider, March 2020
- UMA Advanced Physician Leadership Development, January 2018
- Hands-On Stem Cell Therapies and Biologics for the Clinical Application of Pain Management and Musculoskeletal Medicine, November 2017
- Buprenorphine waiver training completed, May 2015
- Utah Physician Leadership Development: Proven Skills for a New Era in Health Care, March 2015
- Regenerative Medicine Course, AAPMR annual assembly, November 2014
Honors And Awards
- UVA Department of PM&R SAE-R High Score Award, 2006
- President's Citation Award, 2004 AAPMR Annual Meeting
- Phi Kappa Phi
- Cum Laude
- Full Tuition Academic Scholarship 1995-1998
Publications Presentations
- Disc progenitor cell therapy improves pain, disability, and quality of life for patients with lumbar disc degeneration: results of an FDA-approved clinical trial, The Spine Journal, 22, 9, S20-S21, 2022, https://doi.org/10.1016/j.spinee.2022.06.054
- Lumbar Facet Cyst Removal Using Minimally Invasive Endoscopy: A Case Report, American Academy of Physical Medicine and Rehabilitation Annual Convention, Boston, MA, September 19, 2007, Archives of Physical Medicine and Rehabilitation 2007
- Exercise associated muscle cramps: the effects of IV rehydration on serum electrolytes, creatine kinase, fluid balance, and substrate metabolism, South East American College of Sports Medicine, Charlotte, NC, February 8-10, 2007
- Demographics and epidemiology of golf-related head trauma, American Academy of Physical Medicine and Rehabilitation Annual Convention, Phoenix, AZ, October 8, 2004, Archives of Physical Medicine and Rehabilitation
- Outcome after hip fracture in patients with dementia: A pilot study, American Academy of Physical Medicine and Rehabilitation Annual Convention, Phoenix, AZ, October 8, 2004, Archives of Physical Medicine and Rehabilitation
- Higher Hemoglobin levels appear to correlate with a greater rate of functional recovery after total knee arthroplasty, American Academy of Physical Medicine and Rehabilitation Annual Convention, Phoenix, AZ, October 8, 2004, Archives of Physical Medicine and Rehabilitation
- Traditional Tongan Cures for Morning Sickness and Their Mutagenic/Toxicological Evaluations, J. Ethnopharmocol., 71, 201-209, 2000
- Wilderness Dermatology, AWLS certification, Snowmass CO, July 2006
- Wound and Burn Management: Common Skin Injuries, University of Utah, Salt Lake City, UT, April 2005
- Hiking Medicine, University of Utah, Salt Lake City, UT, April 2005
- Osteoporosis Prevention and Treatment, University of Virginia Cardiac Rehabilitation Center, Charlottesville, VA, 2004
Clinical Research Experience
- Pfizer Good Clinical Practice w/ICH Component current
- NIH Human Subjects Research Training –current
2013: A Prospective, Randomized, Controlled Pivotal Clinical Investigation of the XXXX® Spinal Stabilization System in Patients with Lumbar Degenerative Disc Disease
2013: A Pivotal, Multi-Center, Double-Blind Study of the Safety and Effectiveness of XXX (XX) in Patients with Mild to Moderate Osteoarthritis of the Hip
2012-2013: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study To Evaluate The Efficacy And Safety Of XXX In Subjects With Neuropathic Pain From Lumbosacral Radiculopathy
2013: A Multicenter, Randomized, Double-blind, Controlled, Comparative Study of
XXX in Patients with Lumbar Disc Herniation (Phase III)
2014: A Randomized, Double-blind, Placebo-controlled, Multi-dose Phase 2 Study Evaluating the Safety and Efficacy of Intra-articular Injections of XXX in Subjects with Mild to Moderate Patello-Femoral Osteoarthritis Involving Both Knees
2015: A Randomized, Double-Blind, Multi-Dose, Placebo-Controlled Study to
Evaluate the Efficacy and Safety of XXX in Patients with Pain due to Osteoarthritis of the Knee or Hip
2015: MSB-DR003: A Prospective, Multicenter, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Single Injection of XXXX Alone or Combined with Hyaluronic Acid (HA) in Subjects with Chronic Discogenic Lumbar Back Pain Through 12 Months
Amended to: MSB-DR003: A Prospective, Multicenter, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Single Injection of XXX Alone or Combined with Hyaluronic Acid (HA) in Subjects with Chronic Low Back Pain
2015: A Multicenter, Open-label study of XXX in Patients with Lumbar Disc Herniation (Phase III) Protocol number: 6603-1132 (217079)
2015-16: A Multicenter, Non-Treatment, Follow-up Study to Assess the Health Economic Outcomes of Previous Pulsed Electromagnetic Field (PEMF) Therapy in the Treatment of Persistent Post-Operative Pain Following Lumbar Surgery #RBI.2015.001B
2016: A Phase 3, Randomized, Double Blind, Placebo And Active Controlled, Multicenter, Parallel Group Study Of The Analgesic Efficacy And Safety Of XXX In Adult Subjects With Chronic Low Back Pain #A4091059
2016 HS-16-555: A Phase III, Randomized, Double-Blind, Placebo-Controlled, Enriched-Enrollment Withdrawal, Multicenter Study to Evaluate the Efficacy and Safety of a Long-Acting Subcutaneous Injectable Depot of XXX (XX) in Subjects with a Recent History of Moderate to Severe Chronic Low Back Pain Currently Treated with Opioids
2018: TO START: Protocol TGC12301: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Phase 3 Study to Determine the Efficacy of XXX in Subjects with Kellgren and Lawrence Grade 2 or 3 Osteoarthritis of the Knee
2018: DGX-A01: A Prospective, Randomized, Double-Blinded, Vehicle-and Placebo-Controlled, Multicenter Study to Evaluate the Safety and Preliminary Efficacy of XXX in Subjects with Single-Level, Symptomatic Lumbar Intervertebral Disc Degeneration
2019: SM04690-OA-11 A Phase 3, 56-Week, Multicenter, Randomized, Double-Blind, Vehicle-Controlled Study Utilizing Patient Reported and Radiographic Outcomes to Evaluate the Efficacy and Safety of a Single Injection of XXX Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects
2019: Corticosteroid Lumbar Epidural Analgesia for Radiculopathy (C.L.E.A.R.)
2019- SM04690-OA-10 A Phase 3, 28-Week, Multicenter, Randomized, Double-Blind,
Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Single Injection of XXX Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects
2020-SM04690-OA-07 A 48-Week, Placebo-Controlled, Single Blind Extension Study
Evaluating the Safety and Efficacy of XXX in Subjects with Osteoarthritis of the Knee
2020 - A Phase 3, 14-Day, Double-blind, Randomized, Placebo-Controlled, Multicenter
Study of the Efficacy and Safety of XXX 100 mg and 200 mg TID in Subjects with Pain Due to Acute Back Muscle Spasm
2020 to- An Open-Label, Single Ascending Dose Study to Assess the Safety and
Tolerability of XXX in Patients with Osteoarthritis of the Knee
2019-2022 A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel-
Group, Dose-Ranging Study to Evaluate the Efficacy and Safety of 3 Doses of XXX as
Compared to Placebo After 12 Weeks of Treatment in Patients with Treatment-Resistant
Hypertension (rHTN)
2022: Protocol TGC12301: A Randomized, Double-Blind, Placebo-Controlled, Multi-
Center, Phase 3 Study to Determine the Efficacy of XXX in Subjects with Kellgren and
Lawrence Grade 2 or 3 Osteoarthritis of the Knee (previously on hold since 2018)
2022: A Phase 2, Randomized, Double-blind, Placebo-controlled, Parallel Group,
Multicenter Study to Evaluate the Safety and Efficacy of XXX in Subjects with
Moderate to Severe Acute Lower Back Pain
2022: RTX-OAK-201 A Phase 2, Randomized, Active and Placebo-Controlled,
Dose-Ranging Study to Evaluate the Efficacy and Safety of Intra-Articular XXXX to
Treat Moderate to Severe Pain from Knee Osteoarthritis (RTX-OAK-201)
2023: as PI: Sciatica Epidural Radiculopathy Experimental New Interventional
TherapY Clonidine Micropellet
2024: Start as Sub-I: Protocol I8F-MC-GPGN(a) The Effect of XXXXX versus XXXXX on Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes (SURPASS-CVOT) Angela Krull, MD/Study Listing (04/16/2024)
2024: Start as Sub-I: A Phase 3, Randomized, Double-Blind Study to Investigate the
Efficacy and Safety of Once- Daily Oral XXXXX Compared with Placebo in Adult
Participants with Obesity or Overweight with Weight-Related Comorbidities (ATTAIN-1). Protocol: J2A-MC-GZGP
2024: Start as Sub-I: A Phase 3, Randomized, Double-Blind, Parallel-Group, Event- Driven, Cardiovascular Safety Study with BI XXXXX Administered Subcutaneously Compared with Placebo in Participants with Overweight or Obesity with Established Cardiovascular Disease (CVD) or Chronic Kidney Disease, And/or at Least Two Weight- Related Complications or Risk Factors for CVD.
2024: Start as PI: A Randomized, Double-Blind, Single Ascending Dose Phase 1 Study of XXXX Intra-Articular Injection for Subjects with Mild to Moderate Osteoarthritis of the Knee
2024: Start as PI: A Phase 3, Multicenter, Randomized, Double-blind, Single-dose Study to Evaluate the Efficacy and Safety of XXXXX in Subjects with Glenohumeral OsteoarthritisPfizer
Training
- Immune Advanced Practice Module (IFM), March 2024
- Cardiometabolic Advanced Practice Module (IFM), January 2024
- Applying Functional Medicine in Clinical Practice APM (IFM), December 2023
- Environmental Health Advanced Practice Module (IFM), October 2023
- Gastrointestinal Advanced Practice Module (IFM), October 2023
- Bioenergetics Advanced Practice Module (IFM), August 2023
- Hormone Advanced Practice Module (IFM), July 2023
- FIG Education Life Care Planning Certification Class, June 2021
- Relievant Intracept Training and Cadaver Course, February 2021
- Vertiflex Training and Cadaver Course, December 2020
- Utah Medical Cannabis Qualified Medical Provider, March 2020
- UMA Advanced Physician Leadership Development, January 2018
- Hands-On Stem Cell Therapies and Biologics for the Clinical Application of Pain Management and Musculoskeletal Medicine, November 2017
- Buprenorphine waiver training completed, May 2015
- Utah Physician Leadership Development: Proven Skills for a New Era in Health Care, March 2015
- Regenerative Medicine Course, AAPMR annual assembly, November 2014
Honors And Awards
- UVA Department of PM&R SAE-R High Score Award, 2006
- President's Citation Award, 2004 AAPMR Annual Meeting
- Phi Kappa Phi
- Cum Laude
- Full Tuition Academic Scholarship 1995-1998
Publications Presentations
- Allogenic Disc Progenitor Cells Safely Increase Volume and Improve Pain, Disability and Quality of Life in Patients with Lumbar Disc Degeneration-Results of an FDA Approved Biologic Therapy Randomized Clinic Trial, International Journal of Spine Surgery, 18, 3, 2024, https://www.ijssurgery.com/content/early/2024/06/25/8609/tab-article-info
- A randomized, placebo-controlled trial of long-acting dexamethasone viscous gel delivered by transforaminal injection for lumbosacral radicular pain. PAIN ():10.1097/j.pain.0000000000003287, June 14, 2024. | DOI: 10.1097/j.pain.0000000000003287.journals.lww.com/pain/fulltext/9900/a_randomized,_placebo_controlled_trial_of.626.aspx
- Disc progenitor cell therapy improves pain, disability, and quality of life for patients with lumbar disc degeneration: results of an FDA-approved clinical trial, The Spine Journal, 22, 9, S20-S21, 2022, https://doi.org/10.1016/j.spinee.2022.06.054
- Lumbar Facet Cyst Removal Using Minimally Invasive Endoscopy: A Case Report, American Academy of Physical Medicine and Rehabilitation Annual Convention, Boston, MA, September 19, 2007, Archives of Physical Medicine and Rehabilitation 2007
- Exercise associated muscle cramps: the effects of IV rehydration on serum electrolytes, creatine kinase, fluid balance, and substrate metabolism, South East American College of Sports Medicine, Charlotte, NC, February 8-10, 2007
- Demographics and epidemiology of golf-related head trauma, American Academy of Physical Medicine and Rehabilitation Annual Convention, Phoenix, AZ, October 8, 2004, Archives of Physical Medicine and Rehabilitation
- Outcome after hip fracture in patients with dementia: A pilot study, American Academy of Physical Medicine and Rehabilitation Annual Convention, Phoenix, AZ, October 8, 2004, Archives of Physical Medicine and Rehabilitation
- Higher Hemoglobin levels appear to correlate with a greater rate of functional recovery after total knee arthroplasty, American Academy of Physical Medicine and Rehabilitation Annual Convention, Phoenix, AZ, October 8, 2004, Archives of Physical Medicine and Rehabilitation
- Traditional Tongan Cures for Morning Sickness and Their Mutagenic/Toxicological Evaluations, J. Ethnopharmocol., 71, 201-209, 2000
- Wilderness Dermatology, AWLS certification, Snowmass CO, July 2006
- Wound and Burn Management: Common Skin Injuries, University of Utah, Salt Lake City, UT, April 2005
- Hiking Medicine, University of Utah, Salt Lake City, UT, April 2005
- Osteoporosis Prevention and Treatment, University of Virginia Cardiac Rehabilitation Center, Charlottesville, VA, 2004
Clinical Research Experience
- Pfizer Good Clinical Practice w/ICH Component current
- NIH Human Subjects Research Training –current
2013: A Prospective, Randomized, Controlled Pivotal Clinical Investigation of the XXXX® Spinal Stabilization System in Patients with Lumbar Degenerative Disc Disease
2013: A Pivotal, Multi-Center, Double-Blind Study of the Safety and Effectiveness of XXX (XX) in Patients with Mild to Moderate Osteoarthritis of the Hip
2012-2013: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study To Evaluate The Efficacy And Safety Of XXX In Subjects With Neuropathic Pain From Lumbosacral Radiculopathy
2013: A Multicenter, Randomized, Double-blind, Controlled, Comparative Study of
XXX in Patients with Lumbar Disc Herniation (Phase III)
2014: A Randomized, Double-blind, Placebo-controlled, Multi-dose Phase 2 Study Evaluating the Safety and Efficacy of Intra-articular Injections of XXX in Subjects with Mild to Moderate Patello-Femoral Osteoarthritis Involving Both Knees
2015: A Randomized, Double-Blind, Multi-Dose, Placebo-Controlled Study to
Evaluate the Efficacy and Safety of XXX in Patients with Pain due to Osteoarthritis of the Knee or Hip
2015: MSB-DR003: A Prospective, Multicenter, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Single Injection of XXXX Alone or Combined with Hyaluronic Acid (HA) in Subjects with Chronic Discogenic Lumbar Back Pain Through 12 Months
Amended to: MSB-DR003: A Prospective, Multicenter, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Single Injection of XXX Alone or Combined with Hyaluronic Acid (HA) in Subjects with Chronic Low Back Pain
2015: A Multicenter, Open-label study of XXX in Patients with Lumbar Disc Herniation (Phase III) Protocol number: 6603-1132 (217079)
2015-16: A Multicenter, Non-Treatment, Follow-up Study to Assess the Health Economic Outcomes of Previous Pulsed Electromagnetic Field (PEMF) Therapy in the Treatment of Persistent Post-Operative Pain Following Lumbar Surgery #RBI.2015.001B
2016: A Phase 3, Randomized, Double Blind, Placebo And Active Controlled, Multicenter, Parallel Group Study Of The Analgesic Efficacy And Safety Of XXX In Adult Subjects With Chronic Low Back Pain #A4091059
2016 HS-16-555: A Phase III, Randomized, Double-Blind, Placebo-Controlled, Enriched-Enrollment Withdrawal, Multicenter Study to Evaluate the Efficacy and Safety of a Long-Acting Subcutaneous Injectable Depot of XXX (XX) in Subjects with a Recent History of Moderate to Severe Chronic Low Back Pain Currently Treated with Opioids
2018: TO START: Protocol TGC12301: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Phase 3 Study to Determine the Efficacy of XXX in Subjects with Kellgren and Lawrence Grade 2 or 3 Osteoarthritis of the Knee
2018: DGX-A01: A Prospective, Randomized, Double-Blinded, Vehicle-and Placebo-Controlled, Multicenter Study to Evaluate the Safety and Preliminary Efficacy of XXX in Subjects with Single-Level, Symptomatic Lumbar Intervertebral Disc Degeneration
2019: SM04690-OA-11 A Phase 3, 56-Week, Multicenter, Randomized, Double-Blind, Vehicle-Controlled Study Utilizing Patient Reported and Radiographic Outcomes to Evaluate the Efficacy and Safety of a Single Injection of XXX Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects
2019: Corticosteroid Lumbar Epidural Analgesia for Radiculopathy (C.L.E.A.R.)
2019- SM04690-OA-10 A Phase 3, 28-Week, Multicenter, Randomized, Double-Blind,
Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Single Injection of XXX Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects
2020-SM04690-OA-07 A 48-Week, Placebo-Controlled, Single Blind Extension Study
Evaluating the Safety and Efficacy of XXX in Subjects with Osteoarthritis of the Knee
2020 - A Phase 3, 14-Day, Double-blind, Randomized, Placebo-Controlled, Multicenter
Study of the Efficacy and Safety of XXX 100 mg and 200 mg TID in Subjects with Pain Due to Acute Back Muscle Spasm
2020 to- An Open-Label, Single Ascending Dose Study to Assess the Safety and
Tolerability of XXX in Patients with Osteoarthritis of the Knee
2019-2022 A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel-
Group, Dose-Ranging Study to Evaluate the Efficacy and Safety of 3 Doses of XXX as
Compared to Placebo After 12 Weeks of Treatment in Patients with Treatment-Resistant
Hypertension (rHTN)
2022: Protocol TGC12301: A Randomized, Double-Blind, Placebo-Controlled, Multi-
Center, Phase 3 Study to Determine the Efficacy of XXX in Subjects with Kellgren and
Lawrence Grade 2 or 3 Osteoarthritis of the Knee (previously on hold since 2018)
2022: A Phase 2, Randomized, Double-blind, Placebo-controlled, Parallel Group,
Multicenter Study to Evaluate the Safety and Efficacy of XXX in Subjects with
Moderate to Severe Acute Lower Back Pain
2022: RTX-OAK-201 A Phase 2, Randomized, Active and Placebo-Controlled,
Dose-Ranging Study to Evaluate the Efficacy and Safety of Intra-Articular XXXX to
Treat Moderate to Severe Pain from Knee Osteoarthritis (RTX-OAK-201)
2023: as PI: Sciatica Epidural Radiculopathy Experimental New Interventional
TherapY Clonidine Micropellet
2024: Start as Sub-I: Protocol I8F-MC-GPGN(a) The Effect of XXXXX versus XXXXX on Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes (SURPASS-CVOT) Angela Krull, MD/Study Listing (04/16/2024)
2024: Start as Sub-I: A Phase 3, Randomized, Double-Blind Study to Investigate the
Efficacy and Safety of Once- Daily Oral XXXXX Compared with Placebo in Adult
Participants with Obesity or Overweight with Weight-Related Comorbidities (ATTAIN-1). Protocol: J2A-MC-GZGP
2024: Start as Sub-I: A Phase 3, Randomized, Double-Blind, Parallel-Group, Event- Driven, Cardiovascular Safety Study with BI XXXXX Administered Subcutaneously Compared with Placebo in Participants with Overweight or Obesity with Established Cardiovascular Disease (CVD) or Chronic Kidney Disease, And/or at Least Two Weight- Related Complications or Risk Factors for CVD.
2024: Start as PI: A Randomized, Double-Blind, Single Ascending Dose Phase 1 Study of XXXX Intra-Articular Injection for Subjects with Mild to Moderate Osteoarthritis of the Knee
2024: Start as PI: A Phase 3, Multicenter, Randomized, Double-blind, Single-dose Study to Evaluate the Efficacy and Safety of XXXXX in Subjects with Glenohumeral OsteoarthritisPfizer
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