BRINDA KAMALIA
Summary
Research professional with 8+ years in drug discovery and assay development, skilled in advanced molecular biology techniques and high-throughput platforms. Demonstrated success in leading cross-functional projects and creating standardized protocols that improve efficiency and quality in biotech settings. Strong ability to compile and present research findings accurately and swiftly. History of organizing projects to achieve optimal results.
Overview
9
9
years of professional experience
Work History
Senior Research Associate
Eikon Therapeutics
Millbrae, CA
03.2023 - Current
- Design and perform target validation studies, cell line profiling, and cell-based assays to facilitate drug discovery initiatives.
- Developed a high-throughput platform for drug combination studies, significantly streamlining research processes, and fostering collaborative innovation across software, automation, and research teams.
- Conducted laboratory experiments, including cell culture, ELISA, western blotting, PCR assays and other molecular biology techniques.
- Developed and implemented research protocols to evaluate the efficacy of novel therapeutic compounds.
- Performed data analysis utilizing Spotfire, ImageJ, MetaXpress, and GraphPad Prism to derive actionable insights, improving research outcomes, and decision-making.
- Maintained detailed records of experimental protocols and data in electronic laboratory notebooks.
Research Specialist
University of Pennsylvania
Philadelphia, PA
10.2017 - 08.2022
- Developed a screening platform for identifying antivirals against SARS-CoV-2 infection, utilizing high-content image acquisition and analysis.
- Designed, optimized, and executed cell-based assays for primary human cancers, operating automated liquid handlers (JANUS, Tecan D300e), and plate readers (Envision, ImageXpress).
- Programmed protocols for dose-response and synergy experiments on the D300, optimizing cost, time, and compound consumption.
- Conducted data normalization, visualization, and complex analyses using Spotfire and Prism GraphPad.
- Contributed significantly towards generating data for publication in high impact journals
Biochemical Assay Development Co-op
GlaxoSmithKline (GSK)
Collegeville, PA
06.2016 - 12.2016
- Streamlined automation workflows for the Biomek NX significantly reducing task completion time and enhancing team efficiency in R&D.
- Collaborated with team members to design experiments and analyze data using Spotfire and JMP, enhancing presentations with clear visualizations.
- Contributed to the timely completion of multiple high-throughput screens within six months, showcasing effective collaboration and teamwork.
Education
M.S. - Biomedical Science
Drexel University
B.A. - Biology & Economics
New York University
Skills
- High-throughput screening
- Cell-based assays
- Automation workflows
- Design of Experiments (DoE)
- Target validation
- Molecular biology techniques
- MS Office Suite
- Spotfire
- GraphPad Prism
- JMP
- Python
- SQL
- R
- MATLAB
- Cross-functional collaboration
- Project leadership
Publications
- Dittmar, M., et al.,Nucleoside analogs NM107 and AT-527 are antiviral against rubella virus., PNAS Nexus, 2023
- Schultz, D.C., et al., Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2., Nature, 2022
- Li, M., et al., Pharmacological activation of STING blocks SARS-CoV-2 infection., Science Immunology, 2021
- Dittmar, M., et al., Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2., Cell Reports, 2021
Timeline
Senior Research Associate
Eikon Therapeutics
03.2023 - Current
Research Specialist
University of Pennsylvania
10.2017 - 08.2022
Biochemical Assay Development Co-op
GlaxoSmithKline (GSK)
06.2016 - 12.2016
M.S. - Biomedical Science
Drexel University
B.A. - Biology & Economics
New York University
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