Caley Hogan
MADISON,WI
Summary
Experienced scientist with a strong background in molecular biology, laboratory skills, and genetic engineering. Excellent organizational and multi-tasking skills allow for the ability to work on multiple projects at once. Capable of independent experimental design and troubleshooting. Comfortable presenting data to colleagues as well as public presentations.
Overview
12
12
years of professional experience
Work History
Scientist
University of Wisconsin- Madison
01.2020 - Current
- Conducted research on the impact of traumatic brain injury (TBI) on sleep patterns in fruit flies to establish that flies are a clinically relevant model of TBI.
- Used CRISPR to develop a model to study the endogenous role of Appl, the Drosophila homolog of human amyloid precursor protein (APP), which is linked to familial Alzheimer's disease in humans.
- Used qPCR to measure gene expression changes in Appl mutant flies before and after traumatic brain injury.
- Executed independent experiment design and research strategy development.
- Regularly prepared reports summarizing research results for presentation to colleagues and supervisors.
- Utilized statistical software, like GraphPad Prism, to analyze experimental data for trend identification and anomaly detection.
PhD Researcher
University of Wisconsin- Madison
01.2013 - 01.2020
- Lead investigator on a project that identified and characterized a novel gene critical for synaptic growth and function in fruit flies.
- Used bioinformatic data to identify potential novel synaptic genes and characterized those candidates with a high-throughput RNAi screen.
- Utilized CRISPR to generate null mutants and endogenously tagged proteins for high-throughput screening of putative synaptic genes.
- Assessed protein interactions through in vivo by extracting proteins from adult fruit flies, then performing HPLC-MS, and in vitro using transfection and subsequent co-immunoprecipitation in S2 cell culture.
- Presented research at scientific meetings, including the annual Society for Neuroscience and Genetics Society of America: Drosophila Research Conference.
Education
PhD - Genetics
University of Wisconsin- Madison
01.2020
B.S. - Genetics
University of Wisconsin- Madison
01.2013
Skills
- Microsoft Office
- Fiji
- Graphpad Prism
- Adobe Creative Cloud
- MATLAB
- CRISPR gene editing
- Confocal microscopy
- PCR
- Reverse transcription PCR
- DNA and RNA purification
- qPCR
- Extracting and purifying proteins from tissue samples
- Protein immunoprecipitation
- Cell culture
- Experiment protocol development
Publications
- TRNA modification enzyme-dependent redox homeostasis regulates synapse formation and memory, Madhwani KR, Sayied S, Ogata CH, Hogan CA, Lentini JM, Mallik M, Dumouchel JL, Storkebaum E, Fu D, O'Connor-Giles KM, bioRxiv [Preprint], 11/14/23
- Expanded tRNA methyltransferase family member TRMT9B regulates synaptic growth and function, Hogan CA, Gratz SJ, Dumouchel JL, Thakur RS, Delgado A, Lentini JM, Madhwani KR, Fu D, O'Connor-Giles KM, EMBO Rep., 10/9/23
- Genetics of Skeletal Evolution in Unusually Large Mice from Gough Island, Parmenter MD, Gray MM, Hogan CA, Ford IN, Broman KW, Vinyard CJ, Payseur BA, Genetics, 12/1/16
- Genetics of Rapid and Extreme Size Evolution in Island Mice, Gray MM, Parmenter MD, Hogan CA, Ford I, Cuthbert RJ, Ryan PG, Broman KW, Payseur BA, Genetics, 9/1/15
Timeline
Scientist
University of Wisconsin- Madison
01.2020 - Current
PhD Researcher
University of Wisconsin- Madison
01.2013 - 01.2020
PhD - Genetics
University of Wisconsin- Madison
B.S. - Genetics
University of Wisconsin- Madison
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