Dr. Abhijnya Kanugovi

Experienced professional researcher dedicated to advancing scientific knowledge. Demonstrated expertise in designing and executing in vivo and in vitro research experiments resulting in valuable contributions to published studies. Recognized for exceptional teamwork and adaptability, fostering strong collaborations within multidisciplinary teams. Proficient in rodent handling, human samples, data collection, and statistical analysis, leveraging these skills to drive insightful findings and inform evidence-based decision-making.

• Supervised team of 5 staff members.
• Collaborated with team of 12 in the development of pipeline for the isolation and characterization of stem cells from novel rodent and human tissues.

2016 - Best poster presentation award, 14th Annual Conference on Translational Medicine and Oncologists, CA, USA.

2015 - International Travel Award, Department of Science and Technology, Govt. of India.

2015 -Young Scientist Award, Federation of Asian and Oceanian Biochemists and Molecular Biologists.

2015 - Best oral presentation award, Indian Association for Cancer Research, Rajasthan, India.

2014 - International Travel Award, Department of Science and Technology, Govt. of India.

• Peer reviewed 20 articles for internationally recognized journals.
• On the editorial board for 3 journals.
• Moderated the research work of peers for an international journal.
• Supervised the work of 10 research scholars.

• International Society for Stem Cell Research
• Member of the American Society for Cell Biology
• Indian Society for Cell Biology
• Indian Society for Biological Chemists
• Hsp90 society

• Jayesh S Salvi, Jengmin Kang, Soochi Kim, Alex J Colville, Antoine de Morrée, Tine Borum Billeskov, Mikkel Christian Larsen, Abhijnya Kanugovi , Cindy T J van Velthoven, Karlene A Cimprich, Thomas A Rando (2022) “ATR activity controls stem cell quiescence via the cyclin F-SCF complex.” Proc Natl Acad Sci U S A 119 (18).
• AK Vijayavittal , P Kumar, S Sugunan, C Joseph, B Devaki, K Paithankar.... (2022). Heat shock transcription factor HSF2 modulates the autophagy response through the BTG2-SOD2 axis. Biochemical and Biophysical Research Communications.
• A. Kanugovi and S. S Amere (2020). “The conformation- specific Hsp90 inhibition interferes with the oncogenic RAF kinase adaptation and triggers premature cellular senescence, hence, acts as a tumor suppressor mechanism.” BBA-Molecular Cell Research (accepted).
• Kanugovi, A. V. , C. Joseph, S. Siripini, K. Paithankar and S. S. Amere (2020). "Compromising the constitutive p16(INK4a) expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence." J Cell Biochem 121(4): 2770-2781.
• Purushottam Dharaskar, S., K. Paithankar, A. Kanugovi , H. Shabbir Kara and S. Amere Subbarao (2020). "Mitochondrial chaperone, TRAP1 modulates mitochondrial dynamics and promotes tumor metastasis." Mitochondrion 54: 92-101.
• de Morree, A., J. D. D. Klein, Q. Gan, J. Farup, A. Urtasun, A. Kanugovi , B. Bilen, C. T. J. van Velthoven, M. Quarta and T. A. Rando (2019). "Alternative polyadenylation of Pax3 controls muscle stem cell fate and muscle function." Science 366(6466): 734-738.
• AV Kanugovi , S Sugunan, C Joseph, SS Amere (2015). The prosurvival activity of HSF2 in response to autophagic stress is triggered by HSF2-dependent transactivation of BTG2. MOLECULAR BIOLOGY OF THE CELL.
• AV Kanugovi , SS Amere (2014). Oncogene de-addiction from Hsp90 induces senescence-like phenotype in malignant and metastatic tumor cells. MOLECULAR BIOLOGY OF THE CELL.
• U. Sarangi, M.K. Singh, A. Kanugovi , P. A. Lebaka, SP Badabagni, V. V Pitke, K. Paithankar and S. S. Amere (2013). “Hsp60 chaperonin acts as barrier to pharmacologically induced oxidative stress mediated apoptosis in tumor cells with differential stress response.” Drug Target Insights 7: 35-51.
• KVV Abhijnya , AS Sreedhar (2012). Heat shock proteins in the cancer immunity: comprehensive review on potential chemotherapeutic interventions. J. Clin. Cell. Immunol 5, 1-8.
• "Bioinstructive scaffolds enhance stem cell engraftment for functional tissue regeneration after severe trauma". Nature Materials (In press).
• Lemur model. (In revision)
• C1q and muscle fibrosis. (In revision)