Summary
Overview
Work History
Education
Skills
PUBLICATIONS
Timeline
Generic

Joseph Donnelly

San Diego,CA

Summary

Experienced with complex research methodologies and scientific analysis. Utilizes advanced techniques to drive meaningful results in specialized areas. Knowledge of experimental design, pattern recognition, and data interpretation fosters impactful research outcomes.

Overview

15
15
years of professional experience

Work History

Postdoctoral Research Associate

Scripps Research Institute
La Jolla, CA
07.2019 - 02.2025
  • Worked with the Kelly Group studying the pathophysiology of cardiac transthyretin amyloidosis.
  • Pioneered and optimized tissue clearing histology technique for cardiac tissue using techniques originally developed using neurological tissue in an effort to elucidate the cellular pathophysiology of transthyretin amyloidosis via proteomics-guided 3D histological visualization.
  • Led interdisciplinary collaborative study with the Cleveland Clinic investigating early disease biomarkers in known pathogenic variant carriers.
  • Led interdisciplinary research projects, guiding team members in experimental design and execution.

Research Fellow

Cleveland Clinic
Cleveland, OH
06.2017 - 05.2019
  • Led research projects enhancing patient treatment protocols and outcomes.
  • Developed, implemented, and managed clinical study protocols (ClinicalTrials.gov: NCT02792790, NCT03431896).
  • Oversaw data collection, entry, and management of the largest cardiac amyloidosis registry in the USA (800+ patients).
  • Analyzed clinical data and developed abstracts and manuscripts.
  • Designed and created patient education website and materials.
  • Ensured the highest standards of scientific integrity were upheld throughout all stages of the research process.
  • Led monthly interdisciplinary Amyloidosis Center team meeting.
  • Facilitated strong communication among team members through regular meetings, progress reports, and open channels of dialogue.
  • Published research findings in top-tier academic journals, contributing to the advancement of knowledge in the field.

Medical Student Researcher

Hospital of the University of Pennsylvania
Philadelphia, PA
05.2013 - 08.2013
  • Designed and initiated a retrospective investigations of right heart function and clotting and bleeding events in patients with a continuous-flow left ventricular assist device (LVAD).
  • Assisted in the execution of clinical research protocols, ensuring compliance with regulatory standards.

Clinical Research Coordinator

Hospital of the University of Pennsylvania
Philadelphia, PA
09.2009 - 07.2012
  • Managed clinical trial operations, ensuring compliance with regulatory requirements and institutional policies.
  • Coordinated recruitment and screening of study participants, enhancing enrollment processes and timelines.
  • Oversaw data collection and management activities, maintaining accuracy and integrity of study records.
  • Managed the local division of the national INTERMACS registry by collecting clinical data in the outpatient, inpatient, and operating room settings.
  • Followed informed consent processes and maintained records.
  • Enhanced patient safety by meticulously monitoring and documenting adverse events during clinical trials.
  • Worked with principal investigator and sponsors to facilitate daily trial activities and comply with research protocols.
  • Collaborated with clinical staff and other healthcare professionals to support clinical trial data accuracy.

Education

M.D. -

St. George’s University School of Medicine
University Centre, Grenada, West Indies
05-2017

Bachelor of Science - Biology

Villanova University
Villanova, PA
05-2009

Skills

  • Experimental design
  • Research methodologies
  • Laboratory techniques
  • Microscopy techniques
  • Scientific writing
  • Manuscript writing
  • Interdisciplinary coordination
  • Project management
  • Data collection
  • Data entry

PUBLICATIONS

PREPRINT ARTICLE UNDERGOING PEER REVIEW

  • Donnelly JP, Schäfer JH, Yoon L, Massey L, Ash C, Gao Z, Nugroho K, Jäger M, Pang Z, O'Neill RT, Maurer MS, Powers ET, Lander GC, Ye L, Kelly JW. 3D Visualization and Proteomic Analysis of Human Cardiac Transthyretin Amyloidosis Tissue Reveals Microangiopathy and Capillary Occlusion. bioRxiv [Preprint]. 2026 Feb 11:2026.02.09.704431.

PEER-REVIEWED ARTICLES

  • Sperry BW, Khedraki R, Gabrovsek A, Donnelly JP, Kilpatrick S, Shapiro D, Evans PJ, Maschke S, Cotta C, Nakashima M, Seitz W, Hanna M. Cardiac Amyloidosis Screening at Trigger Finger Release Surgery. Am J Cardiol. 2021 Dec 1;160:96-98.
  • Sperry BW, Bock A, DiFilippo FP, Donnelly JP, Hanna M, Jaber WA. Pilot Study of F18-Florbetapir in the Early Evaluation of Cardiac Amyloidosis. Front Cardiovasc Med. 2021 Jun 25;8:693194.
  • Donnelly JP, Sperry BW, Gabrovsek A, Ikram A, Tang WHW, Estep J, Hanna M. Digoxin Use in Cardiac Amyloidosis. Am J Cardiol. 2020 Oct 15;133:134-138. doi: 10.1016/j.amjcard.2020.07.034. Epub 2020 Jul 24.
  • Donnelly JP, Gabrovsek A, Sul L, Cotta C, Rodriguez ER, Tan CD, Hanna M. Evidence of Concurrent Light Chain and Transthyretin Cardiac Amyloidosis in 2 Patients. JACC CardioOncol. 2020 Mar 17;2(1):127-130.
  • Donnelly JP, Hanna M, Sperry BW, Seitz WH Jr. Carpal Tunnel Syndrome: A Potential Early, Red-Flag Sign of Amyloidosis. J Hand Surg Am. 2019 Oct;44(10):868-876.
  • Sperry BW, Reyes BA, Ikram A, Donnelly JP, Phelan D, Jaber WA, Shapiro D, Evans PJ, Maschke S, Kilpatrick SE, Tan CD, Rodriguez ER, Monteiro C, Tang WHW, Kelly JW, Seitz WH Jr, Hanna M. Tenosynovial and Cardiac Amyloidosis in Patients Undergoing Carpal Tunnel Release. J Am Coll Cardiol. 2018 Oct 23;72(17):2040-2050.
  • Ikram A, Donnelly JP, Sperry BW, Samaras C, Valent J, Hanna M. Diflunisal tolerability in transthyretin cardiac amyloidosis: a single center's experience. Amyloid. 2018 Sep;25(3):197-202.
  • Donnelly JP, Hanna M. Cardiac amyloidosis: An update on diagnosis and treatment. Cleve Clin J Med. 2017 Dec;84(12 Suppl 3):12-26.
  • Cesmebasi A, Gabriel A, Niku D, Bukala K, Donnelly J, Fields PJ, Tubbs RS, Loukas M. Pediatric Head and Neck Tumors: An Intra-Demographic Analysis Using the SEER Database. Medical Science Monitor. 2014, Dec; 20(1): 2536-2542. PMID: 25473782.
  • Gabriel A, Donnelly J, Kuc A, Good D, Doros G, Matusz P, Loukas M. Ectopia cordis: a rare congenital anomaly. Clinical Anatomy. 2014, Nov; 27(8): 1193-1199. PMID: 24753313.

ORAL PRESENTATIONS

  • Donnelly JP, Soltesz EG, Tong MZ, Hall SA, Kale P, Estep JD, Hanna M. Heart Transplantation in Cardiac Amyloidosis: A Ten Year Experience. (5 April 2019). MINI ORAL 14: Unique Considerations for Special Heart Transplant Populations. International Society for Heart & Lung Transplantation 39th Annual Meeting and Scientific Sessions; Orlando, FL, USA.
  • Pagani F, Bonde P, Aggarwal S, Donnelly J, Goldstein D, Emani R, Naftel D. (April, 2011). Panel – INTERMACS and Research: Highlights of ISHLT Abstracts. INTERMACS Fifth Annual Meeting; San Diego, CA, USA.

ABSTRACTS & POSTER PRESENTATIONS

  • Donnelly JP, Sperry BW, Ikram A, Samaras C, Valent J, Hanna M. Diflunisal tolerability in cardiac amyloidosis: a single center experience. Poster presented at: ISA 2018. Proceedings of the XVIth International Symposium on Amyloidosis; 2018 Mar 26-29; Kumamoto, Japan.
  • Ikram A, Sperry BW, Donnelly JP, Monteiro C, Phelan D, Tang WHW, Reyes B, Kelly JW, Seitz W, Hanna M. Carpal Tunnel Syndrome and Amyloid Cardiomyopathy. Poster presented at: ISA 2018. Proceedings of the XVIth International Symposium on Amyloidosis; 2018 Mar 26-29; Kumamoto, Japan.
  • Kaul R, Hanna M, Schoenhagen P, Johnston D, Donnelly J, Rodriguez R, Tan C, Hammer D. An Unusual Case of ANP Amyloid Associated with Atrial Thrombus. Poster presented at: ISA 2018. Proceedings of the XVIth International Symposium on Amyloidosis; 2018 Mar 26-29; Kumamoto, Japan.
  • Ikram A, Sperry BW, Donnelly JP, Phelan D, Tang WHW, Reyes B, Seitz W, Hanna M. Carpal Tunnel Syndrome and Amyloid Cardiomyopathy. Poster presented at: HFSA 2017. Proceedings of the Heart Failure Society of America 21st Annual Scientific Meeting; 2017 Sept 16-19; Dallas, TX, USA.
  • Polara FK, Kugasia IR, Donnelly JP, Simmons J, Srinivasan M. Hypertensive Encephalopathy Associated Vasogenic Edema Causing Intracranial Hypertension and Brain Death. Poster presented at: ATS 2017 International Conference. Proceedings of the American Thoracic Society 2017 International Conference; 2017 May 19-24; Washington, DC, USA.
  • Donnelly JP, Hans A. Life-threatening Re-reflux of a Large Hiatus Hernia in an Elderly Patient. Poster presented at: ACP 2017. Proceedings of the American College of Physicians Internal Medicine Meeting 2017; 2017 Mar 30-Apr 1; San Diego, CA, USA.
  • Donnelly JP, Hans A. Life-threatening Re-reflux of a Large Hiatus Hernia in an Elderly Patient. Poster presented at: ACP Delaware 2017. Proceedings of the American College of Physicians Delaware Chapter Scientific Meeting 2017; 2017 Feb; Newark, DE, USA.
  • Zeitler K, Gray J, Miano T, Redline G, Claridge T, Fishman N, Hamilton K, Breuer K, Donnelly J, Rame JE. Incidence of infection during initial hospitalization following long-term ventricular assist device implantation. Poster presented at: ID Week 2012. Proceedings of the Infectious Disease Society of America IDWeek 2012; 2012 Oct 17-21; San Diego, CA, USA.
  • Kobrin DM, Donnelly JP, Acker AL, Howard JL, Zalewski CM, Walsh SL, Hill CE, O'Hara ML, Marble JF, Atluri P, Wald JW, Goldberg LR, Woo YJ, Acker MA, Rame JE. Dynamic BMI changes in patients implanted with continuous flow left ventricular assist devices: Evidence for reversibility of cardiac cachexia and impact on survival. The Journal of Heart and Lung Transplantation. 2013, Apr; 32(4,S1): S90-91.
  • Donnelly JP, Woo YJ, Morris RJ, Goldberg LR, Wald JW, Atluri P, O'Hara ML, Breuer KA, Marble JF, Avrahami NY, Arabia FA, Rogers JG, Acker MA, Rame JE. Does the "obesity paradox" in chronic heart failure fade after mechanical circulatory support with continuous flow devices: Analysis from the Interagency Registry for Mechanically Assisted Circulatory Support. The Journal of Heart and Lung Transplantation. 2011, Apr; 30(4,S1): S33.
  • Atluri P, Ullery BW, MacArthur JW, Kozin ED, Hiesinger W, Donnelly JP, Acker MA, Rame JE, Woo YJ. Continuous Flow Ventricular Assist Devices Improve Functional Tricuspid Regurgitation and Right Ventricular Function. The Journal of Heart and Lung Transplantation. 2011, Apr; 30(4,S1): S19-20.

Timeline

Postdoctoral Research Associate

Scripps Research Institute
07.2019 - 02.2025

Research Fellow

Cleveland Clinic
06.2017 - 05.2019

Medical Student Researcher

Hospital of the University of Pennsylvania
05.2013 - 08.2013

Clinical Research Coordinator

Hospital of the University of Pennsylvania
09.2009 - 07.2012

M.D. -

St. George’s University School of Medicine

Bachelor of Science - Biology

Villanova University

Similar Profiles

CREATE PROFILE
Joseph Donnelly