Grace Nirmala Jesuthankaraj

Passionate researcher in the field of cancer biology and Nanotherapeutics with demonstrated record of research success. Extensive experience in both in vitro and in vivo models. Strong ability in cell-based bioassays. Self-directed and motivated professional with highly-ethical, meticulous and thorough approach.

Guided 10 B.Tech, 3 M.Tech and 6 M.Sc students for their final year project works.

Patent Filed - Dr. Narendhirakannan RT, Grace Nirmala J, Caroline A, Suneera Lincy, Divya Durai – “Derma Hierbas-an ointment for skin rashes” (Patent No. 3775/CHE/2014)

Resource person for ICMR sponsored workshop on “Experimental animals, ethical guidelines and bioefficacy studies for biotechnological applications” organized by Karunya University, Coimbatore on Jan' 2014

Together We Thrive - Mayo Clinic' 2024

• Post Graduate Diploma in Computer application (PGDCA)
• Diploma in nutrition and Health education (DNHE)

1. Grace Nirmala J, Kimaya Meher and Manu Lopus. Proteomic and metabolomic profiling combined with in vitro studies reveal antiproliferative mechanism of silver nanoparticles in MDA-MB-231 breast carcinoma cells. Journal of Materials Chemistry B. 2022 30: 10(13):2148-21592022 

2. Grace Nirmala J, Kavitha Rachineni, Sinjan Choudhary, Ramakrishna V.Hosur and Manu Lopus. Triphala polyphenols-functionalized gold nanoparticles impair cancer cell survival through induction of tubulin dysfunction. Journal of drug delivery science and technology. 61: 102167, 2020

3. Prachi Verma, Praveen Kumar Reddy Nagireddy, Shweta Shyam Prassanawar, Grace Nirmala J, Ankita Gupta, Srinivas Kantevari, Manu Lopus. 9-PAN promotes tubulin- and ROS-mediated cell death in human triple-negative breast cancer cells. The Journal of pharmacy and pharmacology, 72(11), 1585–1594, 2020

4. Grace Nirmala J and Manu Lopus. Tryptone-stabilized gold nanoparticles induce unipolar clustering of supernumerary centrosomes and G1 arrest in triple-negative breast cancer cells. Scientific reports. 9: 19126, 2019

5. Grace Nirmala J, Ashish Beck, Sourabh Mehta and Manu Lopus. Perturbation of tubulin structure by stellate gold nanoparticles retards MDA-MB-231 breast cancer cell viability. Journal of Biological Inorganic Chemistry. 24(7):999-1007, 2019

6. Grace Nirmala J and Manu Lopus. Cell death mechanisms in Eukaryotes. Cell Biology and Toxicology. 36(2):145-164, 2020

7. Grace Nirmala J, Evangeline Celsia S, Akila S, Narendhirakannan RT and Suvro Chatterjee. Cytotoxicity and apoptotic cell death induced by Vitis vinifera peel and seed extracts in A431 skin cancer cells. Cytotechnology. 70(2):537-554, 2018 

8. Grace Nirmala J, Akila S, Muthukumar Nadar MSA, Narendhirakannan RT and Suvro Chatterjee. Biosynthesized Vitis vinifera seed gold nanoparticles induce apoptotic cell death in A431 skin cancer cells. RSC Advances. 6:82205-82218, 2016

9. Grace Nirmala J, Akila S, Narendhirakannan RT and Suvro Chatterjee. Vitis vinifera peel polyphenols stabilized gold nanoparticles induce cytotoxicity and apoptotic cell death in A431 skin cancer cell lines. Advanced powder Technology 28 (4): 1170–1184, 2017

10. Grace Nirmala J and Narendhirakannan RT. Vitis vinifera peel and seed gold nanoparticles exhibit chemopreventive potential, antioxidant activity and induce apoptosis through mutant p53, Bcl-2 and pan cytokeratin down-regulation in experimental animals. Biomedicine & Pharmacotherapy 89: 902-917, 2017

11. Neha Atale, Sharad Saxena, J Grace Nirmala, RT Narendhirakannan. Sujata Mohanty, Vibha Rani. Synthesis and Characterization of Sygyzium cumini Nanoparticles for Its Protective Potential in High Glucose-Induced Cardiac Stress: a Green Approach. Applied Biochemistry and Biotechnology. 181(3):1140-1154, 2017

12. Mano Govindharaj, Sathishkumar Arumugam, Grace Nirmala J, Mausumi Bharadwaj and Kalaiselvam Murugiyan. Effect of Marine Basidiomycetes Fulvifomes sp.- Derived Ergosterol Peroxide on Cytotoxicity and Apoptosis Induction in MCF-7 Cell Line. Journal of Fungi 5:16, 2019

13. Grace Nirmala J and Narendhirakannan RT. Detection and genotyping of high-risk HPV and evaluation of anti-oxidant status in cervical carcinoma patients in Tamil Nadu State, India-a case control study. Asian Pacific Journal of Cancer Prevention 12(10):2689-95, 2011

14. Grace Nirmala J and Narendhirakannan RT. In vitro antioxidant and antimicrobial activities of grapes (Vitis vinifera. L) Seed and skin extracts - Muscat variety. International Journal of Pharmacy and Pharmacological Sciences 3(4): 242-249, 2011

15. Narendhirakannan RT, Grace Nirmala J, Caroline A, Suneera lincy S, Melda saj, Divya S. Evaluation of antibacterial, antioxidant and wound healing properties of seven traditional medicinal plants from India in experimental animals. Asian Pacific Journal of Tropical Biomedicine (S3): S1245-S1253, 2012

16. Yogesh M, Grace Nirmala J, Narendhirakannan RT. Antidiabetic and antioxidant properties of Triticum aestivum in streptozotocin induced diabetic rats. Advances in Pharmacological and pharmaceutical Sciences. 1-9, 2013

17. Smeera Thomas, Grace Nirmala J, Narendhirakannan R.T Free radical scavenging activities of Nyctanthes arbor-tristis. L on adjuvant induced arthritis in rats. British Journal of Pharmaceutical Research. 3(4):536-547, 2013

18. Grace Nirmala J, Kaleeswari R, Paul Pradeep J and Narendhirakannan R.T. Vitis vinifera – the free radical quencher. In: Facets of Biotechnology. SAMS Publishers, Chennai, India. Pp. 139-152. 2013. (ISBN no. 978-93-80485-35-3)

• International Science Congress’ 2013, Karunya University, 12/08/13 - 12/09/13
• National Seminar on Role of Biochemistry and biotechnology in prevention and management of lifestyle disorders, St. Thomas College, Palai, 01/14/13 - 01/15/13
• National level technical symposium (Evogen’ 12), Karunya University, 12/08/12 - 12/09/12
• International conference on Current trends in advanced biomedical technology, Nehru arts and science college, Coimbatore, 10/14/09 - 10/15/09
• Tenth Winter Symposium on Cellular and Molecular Medicine: cancer, stem cells and Inflammation, CMC, Vellore, 01/06/12 - 01/07/12
• International Symposium and congress on Advances in herbal science and technology, MACFAST, Tiruvalla, 11/25/11 - 11/27/11
• International Conference on Breast Cancer, Regional cancer centre, Trivandrum, 07/22/11 - 07/23/11
• National Conference on Oxidative stress and its complications in Human health, Karunya University, 01/19/11 - 01/20/11
• International conference on Human infectious diseases and immunity, Karunya University, 10/14/11 - 10/15/11
• National seminar on Role of immunomodulators in cancer therapy, Karunya University, 10/11/10 - 10/12/10
• Symposium on Good laboratory practices and compliance in biotechnology, IIT Madras and CSIR, 11/03/09 - 11/05/09

• Amnis Imaging Flow cytometry workshop, NIRRH, Mumbai, 04/12/18
• International workshop on Modern Biophysical Tools and Techniques, IIT Bombay, 12/11/17 - 12/15/17
• Recent techniques in cell culture and In vitro cytotoxicity assay, Karunya University, Coimbatore, 09/01/14
• Techniques in animal cell culture and in vitro toxicology, Bharathidasan University, Trichy, 12/01/13
• Biostatistics in biomedical sciences, Karunya University, Coimbatore, 02/01/13
• Process optimization in Animal cell culture, Probiosys center for excellence in life sciences, Bangalore and Dr. GRD college of Sciences, Coimbatore, 08/01/10
• HPLC, Karunya University, Coimbatore, 01/01/10
• Scientific validation of traditional herbal medicine, Bharathiar University, Coimbatore, 12/01/09
• Critical perspectives on research methodology in biomedical sciences, Karunya University, Coimbatore, 10/01/09
• Molecular tools and software-bioinformatics, Neozene Biosciences (P) Ltd, Chennai, 06/01/08

• Member of Youth Red Cross for three years (A grade) during under graduation
• Playing chess, badminton, stitching and listening songs