Lalitha Gopalan
Cincinnati,Ohio
Summary
Dedicated research scientist with DVM, Ph. D. degree in Animal Science and more than 5 years of experience in research using animal models for cancer diagnosis and treatment. Used novel animal models such as chickens to discover biomarkers for early detection of ovarian cancer. Currently, using genetically modified mice models to conduct pre-clinical drug trials for peripheral neurofibromatosis.
Overview
13
13
years of professional experience
Work History
Postdoctoral Fellow
Cincinnati Children's Hospital and Medical Center
2023.01 - Current
- Conducting independent research using C57/BL6 NF1 fl/fl DhhCre+ mice to study peripheral neurofibromatosis (PNF). Including pre-clinical drug trials in these mice.
- Involved in novel projects like flash proton treatment in mice with PNF at Proton therapy center (only one in country for research purposes), Cincinnati Children’s Hospital.
- Developed and designed multi-color flow panel and executed spectral cytometry assays (18+ colors) using FACSCanto/ LSR Fortessa/ Symphony A5/ Cytek Aurora for identifying immune cell types in PNF tumors.
- Characterized immune cell types using immunofluorescence (IF) assays (4+ colors) imaging with confocal and super-high-resolution microscopes.
- Established pipeline for analyzing IF images
- Scheduled and trained technical staff members and potential Ph.D. students.
PhD Graduate Assistant
Penn State University
2017.08 - 2022.12
- Developed and conducted unique research using chickens (laying hens) as animal model for ovarian cancer diagnosis and prevention.
- Collaborated with Actuated Medical ( medical device development company) to detect and collect biopsy samples and develop Photoacoustic System for Identifying Tumor Edges (PSITE).
- Routinely diagnosed ovarian cancer in chickens using ultrasonogram.
- Published manuscript using type-setting software (LaTeX, Overleaf).
- Gained experience in working in BSL-2 lab environment.
- Acquired knowledge in IACUC protocols and AAALAC accreditation systems.
- Mentored undergraduate students to develop their laboratory technical skills.
Livestock Development Officer
Government Of Maharashtra
2013.08 - 2017.05
- Allocated resources, developed budget and recruited personnel for livestock management projects.
- Conducted avian influenza sera-surveillance to monitor and combat disease outbreaks in poultry units.
- Implemented 10+ national schemes to encourage poultry entrepreneurship in rural areas and provided subsidiaries for productivity enhancement in meat and egg production.
- Launched training programs to assist cattle owners in expanding their business in milk production. Conducted quarterly workshops in poultry extension education.
Research Associate Intern
Bombay Veterinary College
2011.08 - 2013.07
- Developed semen preservation techniques and SOPs for extracting domestic cat spermatozoa and conducted extensive semen evaluation using computer-assisted semen analysis (CASA) machine.
- Monitored at-risk-of-abortion pregnancies in canines and felines through Doppler ultrasonograph and analysis of blood-flow patterns to fetal blood vessels.
Education
Ph.D. - Animal Science
Penn State University
State College 12.2022
Master of Science - Master of Animal Reproduction And Gynecology
Bombay Veterinary College
Mumbai, India07.2013
Doctor of Veterinary Medicine - Veterinary Medicine
Bombay Veterinary College
Mumbai, India 07.2011
Skills
- Clinical veterinary : Animal handling, care, ultrasonograms, blood work and other procedures
- Research bench work: Immunofluorescence, multi-color spectral flow cytometry, western blots, qPCR, confocal microscopy
- Analytical: Data analysis, R- programming, RNA-sequencing analysis, image analysis pipeline development
- Communication: Posters, presentations, webinars
Accomplishments
- One first-author publication in Genes. Two manuscripts form PhD thesis in submission form and two manuscripts from postdoctoral research in preparation.
- Worked with a novel animal models (chicken) for ovarian cancer diagnosis and pre-clinical trials for cancer prevention.
- Developing research and techniques to bridge the gap between animal science and human medical research.
- Having a combination of veterinary clinical, researcher (bench work), and bioinformatics skills that can be leveraged for various jobs/positions.
Timeline
Postdoctoral Fellow
Cincinnati Children's Hospital and Medical Center
2023.01 - Current
PhD Graduate Assistant
Penn State University
2017.08 - 2022.12
Livestock Development Officer
Government Of Maharashtra
2013.08 - 2017.05
Research Associate Intern
Bombay Veterinary College
2011.08 - 2013.07
Ph.D. - Animal Science
Penn State University
Master of Science - Master of Animal Reproduction And Gynecology
Bombay Veterinary College
Doctor of Veterinary Medicine - Veterinary Medicine
Bombay Veterinary College
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