Leslie Scarlett
Mount Pleasant,SC
Summary
Board-certified Ophthalmologist & Aesthetic Medicine Specialist with 19+ yrs clinical/surgical experience and 3+ yrs Medical Affairs. Regional/Global Medical Monitor (Ph II–III); expertise in safety review, protocol design, and cross-functional leadership (ophthalmology, rare disease).
Overview
34
34
years of professional experience
1
1
Certification
Work History
Medical Director
ICON plc
PA
11.2025 - Current
- Regional/Global Medical Monitor across Phase II–III trials: safety signal detection/assessment, CRF & lab review, ongoing data quality oversight, and medical input into blinded/unblinded data review
- Lead protocol, ICF, and CRF review with focus on scientific rigor, feasibility, and patient safety; contribute to protocol amendments and study design optimization
- Provide investigator training and medical guidance; serve as primary escalation point for safety issues and complex medical queries
- Drive cross-functional collaboration with Clinical Operations, Biostatistics, Pharmacovigilance, and Regulatory teams to ensure aligned study execution
- Contribute to clinical development strategy, indication planning, and asset-level medical positioning
- Support business development activities including bid defenses, medical strategy input, and client-facing engagements
- Leadership & Strategic Contributions: Cross-functional alignment (clinical/safety/regulatory); senior sponsor-facing leadership; protocol optimization + feasibility strategy; mentorship of junior medical monitors; BD growth contributions
Ophthalmologist (Comprehensive, Aesthetics, Oculoplastics)
Waring Vision Institute
SC
03.2024 - 02.2026
- Comprehensive care; oculoplastics surgery; aesthetics (neurotoxins, fillers, CO2, microneedling)
- Integrated medical and aesthetic practice with focus on patient outcomes and procedural excellence
Expert Consultant
Motley Rice Law Firm
SC
01.2015 - 12.2024
- Medical record review; expert analysis and interpretation
Ophthalmologist (Comprehensive & Oculoplastics)
Carolina Eyecare Physicians
SC
08.2011 - 03.2024
- High-volume (
- Performed oculoplastic procedures and managed complex ophthalmic disease
- Maintained longitudinal patient care with interdisciplinary coordination
Assistant Professor of Ophthalmology
Medical University of South Carolina
SC
07.2007 - 05.2014
- Resident education (clinic/surgery); clinical research; operations oversight
Medical Director
Natural Hideaway Medical Spa
SC
06.2007 - 06.2011
- Clinical oversight; injectables/laser; SOPs, compliance, staffing
Clinical Research
Pennington Biomedical Research Center
LA
01.1992 - 01.1997
- 1996–1997 Site Monitor: site monitoring; ops; regulatory; recruitment; sponsor liaison
- 1992–1996 Clinical Research Assistant: 20 hrs/wk during undergraduate, operational/admin support
Education
MD -
Medical University of South Carolina
Charleston, SCMS - undefined
Baylor College of Medicine
Houston, TXBS - undefined
Louisiana State University
Baton Rouge, LAAesthetic Medicine
01-2025
Oculoplastics
01-2024
Internship, Surgery; Residency, Ophthalmology
Medical University of South Carolina
Charleston, SC01-2007
Skills
- Medical Monitoring
- Clinical Trials (Ph II–III)
- Ophthalmology/Oculoplastics
- Safety/Data Review
- Protocol Dev
- GCP/Regulatory
- Medical Affairs Leadership
- Investigator Engagement
- BD Support
Affiliations
- AAO
- Women in Ophthalmology
- ASLMS
- Medical Society of SC
- Charleston Ophthalmology Society (Past President)
Certification
- South Carolina Medical License No. 24449 (Active since Aug 2004)
- American Board of Ophthalmology (Board Certified)
- American Board of Aesthetic Medicine (Board Certified)
Timeline
Medical Director
ICON plc
11.2025 - Current
Ophthalmologist (Comprehensive, Aesthetics, Oculoplastics)
Waring Vision Institute
03.2024 - 02.2026
Expert Consultant
Motley Rice Law Firm
01.2015 - 12.2024
Ophthalmologist (Comprehensive & Oculoplastics)
Carolina Eyecare Physicians
08.2011 - 03.2024
Assistant Professor of Ophthalmology
Medical University of South Carolina
07.2007 - 05.2014
Medical Director
Natural Hideaway Medical Spa
06.2007 - 06.2011
Clinical Research
Pennington Biomedical Research Center
01.1992 - 01.1997
MS - undefined
Baylor College of Medicine
BS - undefined
Louisiana State University
Aesthetic Medicine
Oculoplastics
MD -
Medical University of South Carolina
Internship, Surgery; Residency, Ophthalmology
Medical University of South Carolina
SELECTED PUBLICATIONS & PRESENTATIONS
- Publications:
- Scarlett L et al. Applicability of MRI Techniques in Endophthalmitis. Ophthalmology. 2007.
- Lal G et al. Interocular Axial Length Difference in Eyes with Pediatric Cataracts. AAPOS. 2005;9:358–362.
- Lucci A et al. National Practice Patterns of Sentinel Lymph Node Dissection for Breast Carcinoma. J Am Coll Surg. 2001;192:453–458.
- Greenway F et al. Treatment of Obese Type 2 Diabetic Men with Either Fenfluramine and Either Mazindol or Phentermine. Journal of Diabetes. 1996.
- Presentations:
- Periop OCT in Cataract Surgery (ASCRS Storm Eye, 2007)
- Application of MRI techniques in Endophthalmitis (ASCRS Storm Eye, 2006)
- Pediatric Cataract IOL Complications (AAPOS, 2006)
- Temporal Arteritis Dx/Biopsy (Storm Eye, 2005)
- Hyperbaric O2 in Treatment of Anterior Segment Ischemia (SCRSC, 2005)
- Axial Length in Pediatric Cataracts (ASCRS, 2003)
- Assessment of the Practice of Sentinel LN Dissection (AAS, 1999)
CLINICAL TRIAL & THERAPEUTIC EXPERIENCE
- Indications: NPDR, DME, Stargardt, AMD (gene therapy), inherited retinal disease, TED, ocular MG, aesthetics/neurotoxin, obesity
- Modalities: Gene therapy
- Biologics
- Small molecules
- Drug-device
SYSTEMS / TECH PLATFORMS
- Medidata Rave
- Argus
- Veeva Vault
- Judi
- LabVantage 360
- Firecrest