Mahmut Mijit, PhD

Clinical Pharmacist and instructor of Physiology and Pharmacology in Medical Education. PhD in Cell biology and Molecular Medicine, Pharmacology, Immuno-Oncology. Over 5 years of expertise in Oncology and anti-inflammatory therapeutic areas (TAs), human solid tumors (PDAC, liver cancer), Autoimmune and Inflammation (AI), Orphan diseases. Skilled at presenting and articulating complex scientific subjects to HCPs/KOLs, C-suite executives, and patients, delivering measurable medical insights in the US and ex-US (China & EU). Expert in scientific writing, slide-deck review and editing, abstract and manuscript submission. Strong publication record, with 7 first-authored and 13 co-authored research articles, 10 presentations at international congresses, symposia. A quick learner with high emotional intelligence, skilled at transferring scientific knowledge, clinical insights, and communication expertise into new TAs.

• Tennis instructor: Applied extensive tennis experience to coach advanced players.
• Pickleball Coach – Bucks County Retirement Center as community services.
• Volunteering at Bucks Country Shelter & Support the Homeless.

• Ref-1 redox activity modulates canonical Wnt signaling in human retinal endothelial cells., ARVO, Seattle, 2024
• Therapeutic Potential of Imvotamab, a CD20-Targeted Bispecific IgM T Cell Engager, for the Treatment of Refractory Autoimmune Disease Patients., ACR, San Diego, CA, 2023
• Inhibition of Ref-1/APE1 redox activity with APX3330 enhances Ref-1/APE1 protein unfolded conformation in human PDAC cells., AACR, New Orleans, USA, 2022
• Activation of Integrated Stress Response (ISR) pathways in response to Ref-1 inhibition human pancreatic cancer and its tumor microenvironment (TMEs)., SfRBM, Orlando, USA, 2022
• SIRT1-mediated cytoprotective effects of RSV against HG stressed HUVECs., FEBS3+ LS2 Annual Meeting, Zurich, Switzerland, 2020
• Sirt1 is essential for beneficial effect of resveratrol on hyperglycemia-induced endothelial dysfunction., General Assembly and Annual Conference of Marie Curie Alumni Association (MCAA), Vienna, Austria, 2019
• SIRT1 activator resveratrol protects HUVECs from high glucose-dependent Redox and glycative imbalances., SfRBM, Las Vegas, USA, 2019
• Protective Effect of 1950 MHz Electromagnetic Field in Human Neuroblastoma Cells Challenged with Menadione., 64th GEI Conference, L`Aquila, Italy, 2018
• Studies of malignant tumors as abnormal savda syndrome in traditional Uyghur medicine: identification of common protein markers and potential therapeutic targets of the prescriptions., 8th International Biophysics Congress (IUPAB), Brisbane, Australia, 2014

• Marie Skłodowska-Curie Action doctoral full scholarship, European Union (2017-2020)
• Melvin and Bren Simon Comprehensive Cancer Center Travel award, USA (2022)
• Best Poster Presentation Award, Abruzzo regional conference, Italy (2017)
• Top 10 Outstanding Scholar Award, Xinjiang Medical University, China (2013)
• American Association of Cancer Research (AACR) membership (2021-Now)
• Society For Redox Biology and Medicine (SfRBM) Membership (2019-Now)
• Italian Society of Developmental and Cell Biology (GEI) Member (2017-Now)
• Marie Skłodowska-Curie Alumni Association Membership (2017-Now)

• In vitro and In vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer., Redox Biology, 2024, 38056311
• Activation of Integrated Stress Response (ISR) pathways in response to APE1/Ref-1 inhibition human pancreatic cancer and its tumor microenvironment (TMEs)., Frontiers in Medicine, 2023, 37181357
• Identification of Novel Pathways Regulated by APE1/Ref-1 in Human Retinal Endothelial Cells., Int J Mol Sci., 2023, 36674619
• RelA is an essential target for enhancing cellular responses to the DNA repair/Ref-1 redox signaling protein and restoring perturbated cellular redox homeostasis in mouse PDAC cells., Frontiers in Oncology., 2022, 35402225
• APE1/Ref-1 - One Target with Multiple Indications: Emerging Aspects and New Directions., J Cell Signal., 2021, 34557865
• Role of p53 in the regulation of cellular senescence., Journal of Biomolecules, 2020, 3218271
• APE1/Ref-1 as a Novel Target for Retinal Diseases., J Cell Signal., 2021, 3432687
• Resveratrol effects on SIRT1-SIRT3-SOD2 axis in high-glucose-challenged HUVECs., In Free Radical Biology and Medicine, 2021
• SIRT1- dependent up-regulation of antiglycative defense in HUVECs is essential for resveratrol protection against high glucose stress., Antioxidants., 2019, 31480513
• Role of Mitochondria in the Oxidative Stress Induced by Electromagnetic Fields: Focus on Reproductive Systems., Oxid Med Cell Longev., 2018, 30533171
• Differential integrative omic analysis for mechanism insights and biomarker discovery of abnormal Savda syndrome and its unique Munziq prescription., Sci Rep., 2016, 27296761
• Metabolic differentiation, and classification of abnormal Savda Munziq's pharmacodynamics role on rat models with different diseases by nuclear magnetic resonance-based metabolomics., Pharmacogn Mag., 2015, 26600713

• Completed multiple comprehensive MSL training workshops, covering aspects of the product life cycle today to day-to-day MSL activities, and passed the course with 100%.
• Clinical Trials: Good Clinical Practice Specialization (Novartis)
• FDA Clinical Investigator Training Course (CITC)
• Regulation of Cell & Gene Therapy Products for Clinical Trials
• Pre Pre-IND and Pre-IND Interactions for Cell and Gene Therapy Products (FDA)