Meisam Bagheri
West Lebanon,NH
Summary
- Self-motivated professional with a Ph.D. in Cell and Molecular Biology and several years of research experience. Aspiring to pursue career opportunities in research with a reputable firm that rewards hard work and appreciates ability and loyalty.
- Skillful and research-driven professional with hands-on experience in recording, interpreting, and analyzing data for driving solutions in the academic sector.
- Adept at organizing, analyzing, and managing large data sets to drive research project success while directing research teams to ensure optimal productivity and efficiency.
- Skilled in analyzing and delivering quantitative and qualitative research-based solutions that reduce redundancy, improve accuracy and efficiency, and achieve organizational objectives.
- Proven ability to analyze and communicate detailed technical and complex information, identify trends using complex data sources, and develop strong relationships with internal and external stakeholders.
- Hardworking researcher bringing 15 years of expertise in cell and molecular biology and center biology. Skilled multitasker with excellent communication and problem-solving skills. Proven history of maintaining equipment and lab areas in alignment with regulatory guidelines.
- Meticulous and analytical Researcher with 15 years of educational and hands-on experience in cell and molecular biology and cancer biology. Adaptive team player with in-depth knowledge of data collection, confidential document control and problem-solving.
Overview
6
6
years of professional experience
Work History
Research Scientist
Dartmouth College, Dartmouth Cancer Center
07.2022 - Current
- Designs and implements research protocols and projects; apply advanced analytical techniques and the modification and extension of theories and practices in innovative research projects; develops statistical and observational models
- Supervise other personnel in the laboratory to coordinate research efforts for increased efficiency and participate in fellows training
- Key Contributions:
- Planning and conducting research experiments, analyzing specific data, and interpreting results
- Prepares grant proposals to obtain funding in support of research activities
- Supplies technical leadership and consultation to professional co-workers, collaborators, and graduate students.
Eisai Co., Ltd
01.2019 - Current
- Academia- Industrial collaboration)
- Understanding and investigating the mechanism of action of eribulin to induce mesenchymal to epithelial transition
- Designing a new strategy to screen and find new and more potent small molecules or drugs to reverse or inhibit EMT
- Key Contributions:
- Designing a new strategy to screen and find new and more potent small molecules or drugs to reverse or inhibit EMT
- Design, conduct, interpret and communicate experiments to identify and validate novel targets.
Postdoctoral Fellow
Dartmouth College, Geisel School of Medicine
11.2018 - 06.2018
- Cancer Biology)
- Design and implement research protocols; design safety procedures; adapt new procedures, methods or instrumentation relative to research procedures
- Supervise other personnel in the laboratory to coordinate research efforts for increased efficiency; participate in training of fellows, residents, students and volunteer workers as needed
- Key Contributions:
- Managed a research project aimed to understand the mechanism of tumor heterogeneity and how it affects therapy resistance and metastasis
- Devised, coordinated, and carried out highly specialized and advanced experiments using existing scientific protocols and processes, as well as created new protocols in some circumstances.
Research Associate
Shiraz University of Basic Medical Sciences
01.2010 - 01.2012
- Molecular Genetics & Gene Therapy Unit of – ADRC
- Plan and conduct research and collect and analyze data
- Reviewed and evaluated data to ensure completeness and accuracy of information; followed up with subjects to resolve problems
- Ensured compliance with protocol and overall objectives
- Conducted weekly meetings with supervisor to plan for class and research-related assignments and assisted in preparing all educational and training workshops and evaluation strategies
- Key Contributions:
- Isolated and manipulated mesenchymal stem cells and dendritic cells able to produce immunosuppressive core peptide
- Cell therapy was used to treat multiple sclerosis in a mouse model.
Animal Center Manager
Shiraz University of Basic Medical Sciences, Shiraz University of
01.2009 - 01.2010
- Molecular Biology:
- Cell culture of primary, immune cell, stem cell and cancer cells, 3D and complex co-culture systems
- Different cell culture related assays, lentiviral production, AAV production, different microscopy techniques, live cell imaging, FRET, FRAP, transfection/electroporation, apoptosis assay etc
- Different types of cloning, sgRNA, shRNA and siRNA designing, CRISPR/Cas9/Cpf1/Base editing, PCR, q-PCR, small molecule and drug screening, CRISPR screening, immunostaining, IHC, multiplexed TSA staining, western blot, enzyme assays, in vitro kinase assay, immunoprecipitation, EMSA etc
- Genomics: scRNA-seq, ATAC-seq, RNA-seq, DNA-seq, CUT&RUN, library preparation
- Proteomics: 2D gel electrophoresis, metabolomics, PISA, proteome thermal shift assay
- Immunology:
- Animal Handling:
- ELISA, isolating different types of immune cells, fellow cytometry, immune cell differentiation and marker staining
- Mouse breeding, genotyping, tumor transplantation, treatment, small surgeries, designing transgenic animals and generating and maintaining PDX and MDX
- Bioinformatics:
- R programming, analyzing multi-omics data, Graph Pad, Microsoft office etc.
Education
Ph.D. - Cell and Molecular Biology
Indian Institute of Science
India 04.2017
Master of Science - Biomedical Genetics
University of Madras
India04.2009
Bachelor of Science - Cell and Molecular Biology
Jahroum University
Iran08.2005
Skills
Cell Biology and Molecular Biology:
Cell culture of primary, immune cell, stem cell and cancer cells, 3D and complex co-culture systems Different cell culture related assays, lentiviral production, AAV production, different microscopy techniques, live cell imaging, FRET, FRAP, transfection/electroporation, apoptosis assay etc
Different types of Cloning, sgRNA, shRNA and siRNA designing, CRISPR/Cas9/Cpf1/Base editing, PCR, q-PCR, small molecule and drug screening, CRISPR screening, immunostaining, IHC, multiplexed TSA staining, western blot, enzyme assays, in vitro kinase assay, immunoprecipitation, EMSA etc
Genomics:
scRNA-seq, ATAC-seq, RNA-seq, DNA-seq, CUT&RUN, library preparation
Proteomics:
2D gel electrophoresis, metabolomics, PISA, proteome thermal shift assay
Immunology:
ELISA, isolating different types of immune cells, fellow cytometry, immune cell differentiation and marker staining
Animal Handling:
Mouse breeding, genotyping, tumor transplantation, treatment, small surgeries, designing transgenic animals and generating and maintaining PDX and MDX
Bioinformatics:
R programming, analyzing multi-omics data, Graph Pad, Microsoft office etc
Affiliations
- Avicenna Research Institute, Tehran, Iran Transgenic and Stem cell techniques, 2009 (6 Months)
- Pasteur Institute of Iran, Tehran, Iran Molecular Laboratory and Cell Culture techniques, 2008 (10 Weeks)
Interests
- Bagheri, M., Nair, R. R., Singh, K. K. & Saini, D. K. ATM-ROS-iNOS axis regulates nitric oxide mediated cellular senescence. BBA - Mol. Cell Res. 1864, 177–190 (2017).
- Nair, R. R., Bagheri, M. & Saini, D. K. Temporally distinct roles of ATM and ROS in genotoxicstress-dependent induction and maintenance of cellular senescence. J. Cell Sci. 128, 342–353 (2015).
- Ravikumar, G., Bagheri, M.
- Saini, D. K. & Chakrapani, H. A small molecule for theraNOstic targeting of cancer cells. Chem. Commun. 53, 13352–13355 (2017). (
- Equal contribution)
- Govindan, R., Bagheri, M.
- Saini, D. D. K. & Chakrapani, D. H. Cancer Targeted Nitric oxide
- Delivery with a Fluorescence Reporter. Free Radic. Biol. Med. 112, 89 (2017). (
- Ravikumar, G., Bagheri, M., Saini, D. K. & Chakrapani, H. FLUORO/NO: A Nitric Oxide Donor with a Fluorescence Reporter. ChemBioChem, 18, 1529–1534 (2017).
- Ardestani, M. S. Bagheri, M., et al. Nanolipodendrosome-loaded glatiramer acetate and myogenic differentiation 1 as augmentation therapeutic strategy approaches in muscular dystrophy. Int. J. Nanomedicine 8, 2943 (2013). Page 1 of 2
Additional Information
- HONORS & AWARDS
- Embassy of Iran, New Delhi Jul 2014 and 2016 The top student award among Iranian students in India.
- CSIR- CFTRI Sep 2016 Best Award for poster and presentation in 85th SBC (I) Annual Meeting, Mysore, India.
- International Cell Senescence Association Jun 2017 Traveler's Grant, Paris, France.
Timeline
Research Scientist
Dartmouth College, Dartmouth Cancer Center
07.2022 - Current
Eisai Co., Ltd
01.2019 - Current
Postdoctoral Fellow
Dartmouth College, Geisel School of Medicine
11.2018 - 06.2018
Research Associate
Shiraz University of Basic Medical Sciences
01.2010 - 01.2012
Animal Center Manager
Shiraz University of Basic Medical Sciences, Shiraz University of
01.2009 - 01.2010
Ph.D. - Cell and Molecular Biology
Indian Institute of Science
Master of Science - Biomedical Genetics
University of Madras
Bachelor of Science - Cell and Molecular Biology
Jahroum University
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