Mohammed Mashali

Davis Heart and Lung Research Institute – Dept. of Physiology and Cell Biology

• Lead investigator in translational research on human myocardial tissue, focusing on metabolic failure, calcium dysregulation, and contractility in end-stage heart failure.
• Managed a donor-heart acquisition program in collaboration with cardiac surgeons at OSU Ross Heart Hospital and Lifeline of Ohio to procure more than 250 IRB-approved failing and non-failing human hearts.
• Coordinated biobank sample requests from national and international collaborators, and prepared and shipped de-identified human heart samples and clinical data.
• Built and maintained a Microsoft Access database to organize donor clinical profiles and procurement metadata, serving as the lab’s main point of contact for clinical information.
• Served as the primary scientific liaison to internal labs and external collaborators, facilitating data integration, and advancing shared hypotheses in cardiac physiology and cardiometabolic mechanisms.
• Participated in scientific discussions with academic cardiologists and clinical collaborators, contributing research context and study updates relevant to heart failure pathophysiology.
• Collaborated with academic and clinical partners to produce publications and share research findings at national cardiology meetings.
• Generated clinically relevant insights from tissue-based studies, supporting the development of therapeutic hypotheses and over $5 million in NIH/AHA grant submissions.
• Co-developed experimental priorities and scientific direction in collaboration with senior investigators to align lab initiatives with translational cardiology goals.
• Mentored and trained more than 10 junior scientists and research fellows on functional analysis, data interpretation, and professional presentation delivery.

Davis Heart and Lung Research Institute – Dept. of Physiology and Cell Biology

• Developed and optimized micro-trabecula dissection and force-kinetics protocols for isolated human myocardium, establishing a reproducible workflow adopted by the lab.
• Executed comparative studies on contractile force and calcium sensitivity in failing versus non-failing ventricular tissue, contributing data to multiple peer-reviewed publications.
• Conducted tissue-based investigations on anthracycline cardiotoxicity and ventricular tachycardia–induced dysfunction, providing mechanistic insights used in conference abstracts at AHA and Biophysical Society meetings.
• Maintained IRB compliance and detailed tracking of human heart specimens, ensuring data integrity from procurement through analysis.
• Assisted in onboarding and supporting junior trainees in experimental workflows and data documentation.

Faculty of Veterinary Medicine - Dept. of Surgery

• Taught advanced surgery and mentored undergraduate students; initiated regenerative‑medicine research projects bridging basic science with clinical application.