Naresh Mutukula

Scientist with extensive experience in human stem cell biology, organoid systems, and aging biology, currently working at Altos Labs. Strong background in evaluating complex biological systems, translating experimental findings into clear insights, and interfacing across wet-lab, computational, and strategic teams. Experienced in assessing scientific feasibility, experimental rigor, and translational potential across frontier life science technologies.

• Organoid and stem cell model development
• Experimental design & biological risk assessment
• Bulk and single-cell RNA-seq interpretation
• Data visualization and presentation (GraphPad, ImageJ, Illustrator)
• Basic Python and R for data analysis

• Mentored graduate and undergraduate trainees
• Led cross-functional project teams
• Experience in grant writing, manuscript review, and scientific evaluation
• Strong written and verbal communication skills for diverse audiences

• Rosebrock D, Arora S, Mutukula N, Volkman R, Gralinska E, Balaskas A, Aragonés Hernández A, Buschow R, Brändl B, Müller FJ, Arndt PF, Vingron M, Elkabetz Y. Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells. Nat Cell Biol. 2022 Jun 13. doi: 10.1038/s41556-022-00929-5. Epub ahead of print. PMID: 35697781.
• Mutukula N, Zhiqiu Man, Yuta Takahashi, Francisca Iniesta Martinez, Mariana Morales, Ester Carreon-Guarnizo, Rocio Hernandez Clares, David Garcia-Bernal, Llanos Martinez Martinez, Jeronimo Lajara, Estrella Nuñez Delicado, Jose E. Meca Lallana, Juan Carlos Izpisua Belmonte, “Generation of RRMS and PPMS specific iPSCs as a platform for modeling Multiple Sclerosis’, Stem Cell Research, Volume 53, 2021, 102319, ISSN 1873-5061, https://doi.org/10.1016/j.scr.2021.102319.
• Mutukula N, Elkabetz Y "Neural Killer" Cells: Autologous Cytotoxic Neural Stem Cells for Fighting Glioma.” Cell Stem Cell. 2017 Apr 6;20(4):426-428. doi: 10.1016/j.stem.2017.03.019.
• Ziv O, Zaritsky A, Yaffe Y, Mutukula N, Edri R, Elkabetz Y “Quantitative Live Imaging of Human Embryonic Stem Cell Derived Neural Rosettes Reveals Structure-Function Dynamics Coupled to Cortical Development.” PLoS Comput Biol. 2015 Oct 16;11(10):e1004453
• Edri R, Yaffe Y, Ziller MJ, Mutukula N, Volkman R, David E, Jacob-Hirsch J, Malcov H, Levy C, Rechavi G, Gat-Viks I, Meissner A, Elkabetz Y “Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors.” Nat Commun. 2015 Mar 23; 6:6500.
• Sharma T, Kumari P, Pincha N, Mutukula N, Saha S, Jana SS, Ta M “Inhibition of Non-Muscle Myosin II Leads to G0/G1 Arrest of Wharton’s Jelly-derived Mesenchymal Stem Cells” Cytotherapy. 2014 May; 16(5):640-52.

Patents:

• Method for the generation of outer radial glial (org) cells. Publication# WO2023166111A1. Mutukula N, Rosebrock D, Arora S, Elkabetz Y.
• Method and system for prenatal and neonatal diagnosis of psychiatric disorders. Publication# WO2024100666A1. Nisim Perets, Nir Waiskopf, Mutukula N, Jonatan Darr, Shmulik Betzalel.
• Systems and methods of reinforced learning in neuronal cultures for assessment of cognitive functions associated with psychiatric disorders (pd) and personalized treatment evaluation. Publication# WO2024100667A1. Nisim Perets, Shmulik Betzalel, Nir Waiskopf, Oren Bouskila, Mutukula N.

• Human stem cell biology & organoid systems (brain, neuromuscular, intestinal, liver)
• Aging biology, senescence, and cellular rejuvenation
• Experimental design, data interpretation, and scientific due diligence
• Translational science & technology evaluation
• Cross-disciplinary collaboration (biology, computation, strategy)
• Scientific writing, synthesis, and presentation