NATASHA CASTROVINCI
West Chester ,USA
Summary
Experienced Clinical Development and Operations leader with 20+ years of success driving global clinical programs across dermatology, oncology, respiratory, cardiovascular, and infectious disease. Proven ability to lead cross-functional teams, optimize vendor partnerships, and deliver results in complex, regulated environments. Skilled in strategic planning, process improvement, and fostering high-performing teams. Known for adaptability, strong communication, and cultivating a culture of collaboration, accountability, and operational excellence within fast-paced biotech and pharmaceutical settings.
Overview
21
21
years of professional experience
Work History
Director
Incyte Corporation
06.2025 - Current
- Lead financial planning, budgeting, and contract negotiations for clinical trials and R&D initiatives, ensuring fiscal accuracy and alignment with corporate objectives.
- Oversee CRO contract lifecycle management, including drafting, negotiation, amendment tracking, and financial compliance.
- Develop and maintain detailed vendor budgets in collaboration with Clinical Development, Clinical Operations, Finance, Global Sourcing, and Legal.
- Monitor budget performance, identify cost variances, and implement corrective actions to optimize financial outcomes.
- Drive financial forecasting and strategic planning efforts, delivering insights that support cross-functional decision-making.
- Champion audit readiness and regulatory adherence through proactive vendor oversight and alignment with industry standards.
- Cultivate a high-performing team environment by mentoring staff, facilitating professional growth, and setting clear performance goals.
- Foster team collaboration, retention, and engagement by building a culture of trust, open communication, and continuous improvement.
Associate Director
Incyte Corporation
01.2022 - 06.2025
- Directed operational strategy and execution of global clinical trials, ensuring on-time delivery and adherence to budget.
- Partnered with senior leadership and CROs to drive program milestones and proactively mitigate operational risks.
- Led and mentored cross-functional teams, including Clinical Trial Managers (CTMs), Clinical Trial Specialists (CTSs), and Clinical Operations Leads (COLs).
- Oversaw CRO and vendor selection processes from RFI through study completion, ensuring alignment with strategic objectives.
- Delivered program updates and resourcing plans to senior management, informing executive decision-making.
- Collaborated with Clinical Scientists and external vendors to establish a centralized photo repository for IAI studies, enhancing accessibility and data traceability post-closeout.
- Served as Indication Lead for the Vitiligo Program within the Ruxolitinib Cream portfolio, providing strategic oversight across development stages.
- Acted as Asset Lead for SPPL2a, an early development program, managing cross-functional coordination and aligning early-phase operations with asset strategy.
Senior Clinical Trial Operations Manager
Incyte Corporation
07.2018 - 01.2022
- Oversaw global clinical trials in oncology and dermatology from start-up through close-out, ensuring alignment with timelines, budgets, and regulatory expectations.
- Directed site engagement strategy, vendor performance, and trial budgets using defined metrics and KPIs.
- Led cross-functional study team meetings and maintained consistent communication across Clinical Operations, Medical Affairs, and Regulatory teams.
- Developed and implemented quality oversight plans and risk mitigation strategies to ensure compliance and study continuity.
- Optimized clinical trial operations through continuous process improvements, leading to measurable efficiency gains and cost savings.
- Achieved enrollment targets ahead of schedule by leveraging innovative recruitment strategies and strengthening site relationships.
- Promoted a culture of compliance and quality through ongoing training, proactive issue identification, and operational best practices.
Global Clinical Project Manager
Teva Pharmaceuticals USA Inc
08.2012 - 07.2018
- Led Phase I–III global respiratory trials ensuring GCP compliance.
- Managed operational forecasting, site strategy, and CRO performance.
- Initiated and led compassionate use programs and developed termination plans.
- Collaborated cross-functionally with medical affairs, safety, and regulatory.
Enterprise Management Consultant
Enterprise Management Consulting, Temple
10.2011 - 03.2012
- Developed strategic framework for UN WFP and Oxfam's $35M risk initiative in Africa.
Marketing Intern
Cancer Genetics, Inc. (CGI)
06.2011 - 08.2011
- Created marketing materials and researched international expansion opportunities in oncology diagnostics.
Clinical Research Site Manager
KFORCE, INC. / PFIZER ALLIANCE
04.2008 - 07.2010
- Maintained site monitoring schedules to facilitate effective communication with members of clinical team.
- Reviewed clinical data, source documentation, case report forms and investigative site regulatory files to verify accuracy and completion.
- Conducted initiation, monitoring and closeout visits to verify study procedures, regulatory documents and data completion.
- Implemented electronic data capturing systems to adhere with clinical research guidelines.
- Traveled to investigative sites to conduct site qualification, initiation, interim monitoring and close-out visits to maintain and enforce regulatory compliance.
Clinical Research Associate
METROPOLITAN RESEARCH ASSOCIATES
09.2006 - 04.2008
- Conducted protocol training, source data verification, and ongoing GCP compliance assessments to support internal and external audits.
- Served as primary site contact for sponsors and CROs, facilitating monitoring visits, addressing data queries, and ensuring timely CRF completion.
- Oversaw regulatory document management, including ICF updates, IRB submissions, and SAE tracking.
- Monitored subject enrollment, visit adherence, and protocol compliance to support enrollment milestones and data integrity.
In House Clinical Research Associate
CARDIOVASCULAR RESEARCH FOUNDATION
01.2006 - 08.2006
- Reviewed regulatory documents, ICFs, and study files to support site activation and monitoring readiness.
- Performed remote monitoring, including source verification, query resolution, and protocol deviation follow-up.
- Maintained TMF documentation to ensure audit and inspection readiness.
- Supported site training, safety reporting, and regulatory submissions in collaboration with study teams.
Study Coordinator I and II
MEMORIAL SLOAN KETTERING CANCER CENTER
New York, New York
07.2004 - 12.2005
- Led coordination of complex clinical studies, ensuring compliance with protocols, regulations, and timelines.
- Oversaw data entry, source verification, and query resolution with sponsors and monitors.
- Monitored participant safety and reported adverse events in collaboration with PIs, IRBs, and sponsors.
- Facilitated study meetings, trainings, and staff oversight to ensure protocol adherence and data quality.
- Served as primary liaison to CROs and vendors, resolving site-level issues and ensuring operational continuity.
Education
MBA - Pharmaceutical Management
Temple University
Philadelphia, PA05.2012
Bachelor of Arts - Biology
Cornell University
Ithaca, NY05.2004
Skills
- Global Clinical Trial Leadership
- Cross-Functional Team Development
- CRO/Vendor Oversight
- Regulatory Compliance (ICH GCP, FDA)
- Operational Excellence
- Risk Mitigation Planning
- Clinical Budget Management
- Patient Recruitment & Retention Strategy
- Strategic planning
Websites
Leadership Initiatives And Strategic Contributions
- Collaborated in the development of the BUBB (Bottom-Up Budget Build) tool for Clinical Operations, standardizing budget planning and assessment across clinical programs.
- Co-developed and implemented a financial training module for Clinical Trial Managers, strengthening budget literacy and enhancing forecasting accuracy.
- Contribute to InProves, a strategic initiative focused on innovation and continuous improvement within Development Operations.
- Selected for Incyte’s Executive Coaching Program (2022), as part of a cohort of 12 emerging leaders.
- Supported the review and evaluation of third-party vendor performance for Investigator Training to ensure educational quality and regulatory compliance.
Professional Development And Presentations
- Dashboard in a Day – Power BI Workshop, Hitachi Solutions
- American Academy of Dermatology Annual Meeting – 2023
- Pennsylvania Conference for Women – 2023
- Incyte Inpowered Discussion Circle – Michele Houghton-Coritz
- Executive Coaching Program with Patrick Murphy – 2022
- Guest Presenter: ‘Leveraging MAPs Post-Trial’ – Idis Insights Forum, Philadelphia
Languages
English
Native or Bilingual
Russian
Professional Working
Timeline
Director
Incyte Corporation
06.2025 - Current
Associate Director
Incyte Corporation
01.2022 - 06.2025
Senior Clinical Trial Operations Manager
Incyte Corporation
07.2018 - 01.2022
Global Clinical Project Manager
Teva Pharmaceuticals USA Inc
08.2012 - 07.2018
Enterprise Management Consultant
Enterprise Management Consulting, Temple
10.2011 - 03.2012
Marketing Intern
Cancer Genetics, Inc. (CGI)
06.2011 - 08.2011
Clinical Research Site Manager
KFORCE, INC. / PFIZER ALLIANCE
04.2008 - 07.2010
Clinical Research Associate
METROPOLITAN RESEARCH ASSOCIATES
09.2006 - 04.2008
In House Clinical Research Associate
CARDIOVASCULAR RESEARCH FOUNDATION
01.2006 - 08.2006
Study Coordinator I and II
MEMORIAL SLOAN KETTERING CANCER CENTER
07.2004 - 12.2005
Bachelor of Arts - Biology
Cornell University
MBA - Pharmaceutical Management
Temple University
Similar Profiles
Christina MotzkoChristina Motzko
Sr. Manager, R&D Finance at Incyte CorporationSr. Manager, R&D Finance at Incyte Corporation
Ronald DoveRonald Dove
Applied Technology Coop at Incyte CorporationApplied Technology Coop at Incyte Corporation
Suzy BAMBARASuzy BAMBARA
Director QA, Global Commercial Distribution at Incyte Biosciences InternationalDirector QA, Global Commercial Distribution at Incyte Biosciences International
Jusephine GhongJusephine Ghong
New-Hire Coordinator/Employee Relations Associate at Koch Foods IncNew-Hire Coordinator/Employee Relations Associate at Koch Foods Inc
Imani JarmonImani Jarmon
Health/PE Teacher at Chester Upland School DistrictHealth/PE Teacher at Chester Upland School District