Naziba Nuha

I am currently exploring the function of the SERPINE1 gene in aggressive fibrotic cancers, including small cell lung cancer (SCLC), pancreatic cancer, and glioblastoma. The methodologies I employ include cell culture, western blotting, and immunofluorescence.

In my role as a medical scribe, I specialized in crafting detailed and precise medical records that adhered to the established standards of the healthcare industry. During my tenure with the company, I successfully transcribed medical notes for a wide variety of medical fields, including obstetrics and gynecology, family medicine, emergency medicine, allergy medicine, and dermatology.

The project focused on developing novel glutamine antagonists as potential preclinical therapeutics for pediatric solid tumors, particularly targeting tumors associated with neurofibromatosis type I (NF1). Emphasizing a translational approach, it included cell-based combination therapy studies, preclinical trials using rodent models of NF1 solid tumors, and the evaluation of metabolic markers to assess the drug's effects. A key accomplishment was the creation of Pro-905, an innovative ProTide purine antimetabolite, which exhibited significant anti-tumor activity as a single agent across various preclinical MPNST models and was well-tolerated. Pro-905's promising results have made it a candidate for further research in other cancer and disease models.

In the summer of 2022, I had the opportunity to work as an orthopedic technician at South Florida Spine and Orthopedics. In this role, I engaged in various orthopedic tasks such as applying and removing dressings, removing sutures/staples, and fitting and removing casts and splints. Additionally, I undertook back office responsibilities, which included preparing examination rooms for patients, recording vital signs and patient histories, and providing support during minor surgical procedures. Most significantly, I dedicated myself to positively impacting the lives of my patients. I consistently made an effort to connect with them, particularly prior to undergoing challenging procedures, with the aim of alleviating their anxiety and ensuring they felt valued and cared for.

At Village Medicine and Hugh Chatham, I played a key role in the development of new scribe programs, observing the methods employed by healthcare providers and documenting their workflows. This process involved consolidating all gathered information into comprehensive notes to establish best practices for the new location. Essentially, I became a central repository of knowledge regarding the site's operations. This enabled me to subsequently train new scribes whom the implementation team was in the process of recruiting for the site.

I was responsible for documenting the physician-dictated patient histories, physical examinations, family, social, and past medical histories, as well as procedures and lab results. I also dictated radiographic impressions as determined by the supervising physician, along with any other relevant information related to patients' encounters in the Emergency Department. My role further extended to providing one-on-one training for new scribes, which included conducting performance evaluations, offering critiques and encouragement. Additionally, I regularly met with leadership to discuss and refine training programs for continuous improvement.

The study focused on the assessment of Epithelial to Mesenchymal Transition (EMT) markers in H460 and HCC827 lung cancer cell lines treated with HDAC inhibitors (SAHA) and a p21 inhibitor (UC2288). Extensive cell culture and western blot experiments were conducted, revealing that SAHA treatment increased the levels of E-cadherin, p21, p27, and SNAIL proteins, while decreasing the expression of Aurora Kinase B and Vimentin. These results highlight the complex interaction between acetylation and methylation mechanisms in the suppression of EMT through HDAC inhibition. The research was awarded 3rd place at the 2021 NSU undergraduate symposium and was presented at the 2021 Life Sciences South Florida symposium.

I documented patient histories, physical examinations, family, social, and past medical histories as dictated by physicians, along with procedures and lab results. I also transcribed radiographic impressions made by the supervising physician and captured any other relevant details from patients' visits to the Emergency Department. My responsibilities included one-on-one training of new scribes at Memorial Regional Hospital, a level I trauma center, where I conducted performance evaluations, provided feedback, and offered encouragement. I frequently met with leadership to discuss and enhance training programs. Additionally, I supported other facilities, including Memorial Pembroke ER, Memorial West ER, and Joe Di Maggio Children's Hospital, contributing my skills where needed.

I documented the patient history, physical examination, family, social, and past medical history as dictated by the physician, in addition to procedures and lab results. I employed both Electronic Health Records (EHR) and paper-based patient records to carry out billing duties and ensure the maintenance of an accurate, legally compliant medical record.