Summary
Overview
Work History
Education
Skills
Publications
Timeline
Generic

Patrick Moore

West Chester,PA

Summary

Highly motivated immunologist with experience in drug discovery, particularly immunoassay development, receptor characterization, and immunology. Expertise in innate immunology, immuno-inflammation, and autoimmune pathologies. Experienced scientist with the ability to work in a highly matrix environment across departments and communicate research plans and results. Team and goal-oriented with strong desire to learn and develop skills at the bench and in cross disciplines of drug development.

Overview

9
9
years of professional experience

Work History

Senior Scientist – Safety Rep, Capital Equipment Champion

GlaxoSmithKline
04.2019 - Current
  • Evaluated hundreds of unique targets with novel genetic associations in collaboration with 23andMe geneticists
  • Led target review across multiple disciplines (biology, tractability, safety, competitive landscape etc.) in collaboration with matrix partners
  • Presented recommendations to several layers of governance boards for next steps including stagegate transitions and go/no-go experiments.
  • Developed and optimized key assays to support go/no-go decisions for novel targets across multiple modalities (small & large molecule)
  • These included primarily: flow-based readouts, internalization assays, receptor expression validation, etc.
  • Primary immune cell assays, including receptor activation/additivity, cytokine release, histamine detection, etc.
  • Co-lead on an external collaboration collecting patient samples for IBD/UC.
  • Served as the safety representative for the department: attended meetings with safety representatives across Collegeville site, EHS departments, cascaded policies to Immunology research unit, ensured compliance throughout the department, etc.

Senior Scientist – Capital Equipment Champion

GlaxoSmithKline
08.2018 - 04.2019
  • Lead biologist on program that developed Jess/ELISA degradation assays in support of the characterization of novel PROTACs.
  • Assisted in uncovering previously unknown pharmacology reducing efficacy of agonists to generate functional antagonists by a partial agonism mechanism.
  • Provided support for a lead optimization program that included cytokine release assays, detection of phosphorylation markers via Jess, etc.
  • Assisted with translational disease package via mouse splenocyte isolation/ex vivo assays and characterization of receptor/cytokine/RNA levels in diseased patient samples.
  • Oversaw the approval, purchase, and maintenance of instruments for the lab.

Scientific Student Worker

GlaxoSmithKline
05.2017 - 08.2018
  • Designed and developed assays to detect biomarkers using WES (automated Western blot) in support of several immuno-inflammation portfolio projects.
  • Designed and executed cellular/molecular biology assays such as luciferase, qPCR, ELISA, etc.
  • Completed a robust thesis project that included the discovery of a novel chemical series.
  • Trained colleagues in the use of WES technology and mentored them in the development of new assays using the technology.

Student Researcher

Drexel University
08.2016 - 05.2017
  • Designed and executed in vitro experiments for the study of dendritic cell responses to a flavonoid-based treatment for Multiple Sclerosis.
  • Characterized and validated pathways involved in inflammation and the activation of dendritic cells.
  • Presented comprehensive data and literature at weekly lab meetings.
  • Interpreted results from experiments and the literature to further design subsequent experiments in metabolism and immune crosstalk.

Associate Scientist

Absorption Systems
10.2014 - 01.2015
  • Designed and executed ADME/DMPK assays for pre-clinical testing.
  • Performed permeability plate assays for drug analytical screening, including inhibition studies.
  • Developed methods for accurate detection of test compounds via LC-MS.
  • Prepared and provided reports of the performed studies for submission to clients.

Education

M.Sc. in Immunology -

Drexel University, School of Medicine
Philadelphia, PA
12.2017

B.Sc. in Biology -

La Salle University
Philadelphia, PA
05.2014

Skills

  • Jess/Wes Simple Western multiplex assay development and Western Blot
  • MSD/ELISA for human/mouse/NHP supernatants and intracellular protein detection
  • Primary immune cell isolation/long-term culture of blood derived mast cells
  • Primary cell assay development, including cytokine release, protein degradation, receptor activation, etc
  • Mammalian cell culture
  • Flow Cytometry
  • RNA isolation/qPCR
  • Tissue homogenization/ex vivo primary cell assays of mouse splenocytes/neutrophils for cytokine release
  • CRISPR knockout of immoratalized and primary cells
  • Softwares including Compass for Simple Western, FlowJo, Graphpad Prism, MSD workbench, Quantstudio

Publications

  • Design of amidobenzimidazole STING receptor agonists with systemic activity, Ramanjulu JM, Pesiridis GS, Yang J, Concha N, Singhaus R, Zhang SY, Tran JL, Moore P, …Bertin J., Nature, 12/2018, 564, 7736, 439-443, 10.1038/s41586-018-0705-y, 30405246
  • Apigenin Modulates Dendritic Cell Activities and Curbs Inflammation Via RelB Inhibition in the Context of Neuroinflammatory Diseases, Ginwala R, Bhavsar R, Moore P, …Jain P., J Neuroimmune Pharmacol, 06/2021, 16, 2, 403-424, 10.1007/s11481-020-09933-8, 32607691, PMC7772281

Timeline

Senior Scientist – Safety Rep, Capital Equipment Champion

GlaxoSmithKline
04.2019 - Current

Senior Scientist – Capital Equipment Champion

GlaxoSmithKline
08.2018 - 04.2019

Scientific Student Worker

GlaxoSmithKline
05.2017 - 08.2018

Student Researcher

Drexel University
08.2016 - 05.2017

Associate Scientist

Absorption Systems
10.2014 - 01.2015

M.Sc. in Immunology -

Drexel University, School of Medicine

B.Sc. in Biology -

La Salle University

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