Shikun 'Rinco' Wang
New Haven,CT
Overview
4
4
years of professional experience
Work History
Graduate Research
Professor David Spiegel's Lab, Yale University
08.2022 - Current
Bifunctional Molecules for the Removal of Extracellular Proteins from the Brain
- Investigated bifunctional molecules' potential in treating neurodegenerative disease
- Developed an assay to monitor bifunctional molecules-mediated transcytosis of extracellular proteins in vitro
Undergraduate Research
Professor Gary Pielak's Lab, UNC Chapel Hill
08.2020 - 08.2022
Attenuated total reflectance Fourier-transform infrared (ATR FTIR) spectroscopy of a tardigrade desiccation tolerance protein
- Studied the secondary structure of tardigrade Cytosolic Abundant Heat Soluble Protein D (CAHS D) to understand its role of desiccation tolerance to understand how structure contributes to function.
Crowding Effect on Protein-Protein Interaction
• Investigated the effect of intracellular environment on the stability of the side-by-side and domain- swapped GB1 dimer.
Education
PhD Candidate - Chemistry| Biophysical Division
Yale University
05-2028
Bachelor of Science -
University of North Carolina (UNC) At Chapel Hill
05-2022
Skills
Biophysics
- Surface Plasmon Resonance (SPR)
- Circular dichroism spectroscopy (CD)
- Nuclear Magnetic Resonance (NMR) spectroscopy
- Attenuated total reflectance Fourier-transform infrared (ATR FTIR) spectroscopy
Chemical Biology
- Confocal Microscopy
- Flow Cytometry
- Protein Purification
- Peptide Synthesis & Purification
- Western Blot
- Cell Culture
Computer Programming and Analysis
- Python
- Matlab
- Mathematica
- MOE (Molecular Operating Environment)
- CryoSPARC
Structural Biology
- Cryogenic electron microscopy (Cryo-EM)
Leadership & Involvement
Teaching Assistant for CHEM222L and CHEM223L Yale University
Vice President UNC Friendship Association of Chinese Students and Scholar UNC Chapel Hill
• Collaborated with local companies and sought sponsorship to support activities on campus
Member of Student Government Committee, Community Service UNC Chapel Hill
Organizer of Raptor Programs for Wildlife Information and Science Education UNC Chapel Hill
Peer Mentor for CHEM101 & BIOL202 UNC Chapel Hill
Peer Tutor at The Learning Center UNC Chapel Hill
Lab Assistant for BIOL252L UNC Chapel Hill
Languages
Mandarin (Native), Cantonese (Native), English (Fluent), Korean (Adequate).
Publications
ChapelHilliko SS, Atkin JM, PiEicherJ. SeBromary structure and stability ofSheiko-formAtkinardigPielakesiccation-tolerance protein. Protein Sci. 2022 Dec;31(12): e4495. doi: 10.1002/Sci.4495. PMID: 36335581; PMCID: PMC9679978.
2)&doip; Wang S, Eicher J, Pielak GJ. Trifluoroethanol and the behavior of a tardigraEichericcaPielakoleraTrifluoroethanoltein Sci. 2023 Aug;32(8): e4716. doi: 10.1002/pSci4716. PMID: 37401908; PMCID: PMC10357939.
3)doisp; Howell, R., Wang, S., et al. Bifuncttranscytosisles that induce targeted degradation and transcytosis of extracellular proteins in brain cells. JACS, 2024, accepted.
Timeline
Graduate Research
Professor David Spiegel's Lab, Yale University
08.2022 - Current
Undergraduate Research
Professor Gary Pielak's Lab, UNC Chapel Hill
08.2020 - 08.2022
PhD Candidate - Chemistry| Biophysical Division
Yale University
Bachelor of Science -
University of North Carolina (UNC) At Chapel Hill
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