I am a biologist with experience in the disciplines of biochemistry and molecular cell biology. I am confident as an independent researcher with a problem-solving attitude and exchanging ideas with colleagues. I have a keen motivation to learn, grow and excel in a research-oriented organization that offers opportunities for upward growth.
Currently my projects revolve around understanding the influence of epigenetic modifications in regulating ageing and gene expression . Heterochromatin maintainance and genome stability is essential for proper functioning of biological system. Our lab focuses on understanding how does a stretch of chromatin "decide" which PTMs ssemble/disassemble? How do they "choose" the levels of those PTMs? Ultimately, we want to understand how cellular answers to these questions lead to developmental or adaptative responses.
My project revolved around understanding the efficacy of probiotics in helath and diseases. The isolation and identification of new strains of probiotics is a continuous ongoing process. The project assessed the curative prospects of the two newly isolated probiotic strains. Adherence to the intestinal epithelial cells is an important criterion a probiotic should satisfy before it is commercialized. New probiotic isolates were studied to assess their degree of adhesion to differentcell lines HT 29, Caco2 and T84. Amongst the three cell lines used in the study, HT 29 and Caco2 served as a good models for adhesion studies.
ORCID: https://orcid.org/0000-0003-3619-8832
Sohini Basu, Protiti Maiti Ghosh, Agamani Ghosal, Suchismita Dutta Geetanjali Sundaram (2022), Transcription factor Atf1-dependent degradation of the mitotic cyclin Cdc13 is regulated by multiple factors in Schizosaccharomyces pombe. FEBS Lett.. https://doi.org/10.1002/1873-3468.14439
Sohini Basu, Priyanka Sarkar, Suchismita Datta, Geetanjali Sundaram Dataset describing the genome wide effects on transcription resulting from alterations in the relative levels of the bZIP transcription factors Atf1 and Pcr1 in Schizosaccharomyces pombe Data in Brief 42 (2022) 108034 doi.org/10.1016/j.dib.2022.108034
Sushobhana Bandyopadhyay, Protiti Maiti Ghosh#, Sohini Basu#, Madhurima Paul, Syed Benazir Alam, Elizabeth Das Geetanjali Sundaram Antagonistic regulation of cyclin expression by the bZIP transcription factors Pcr1 and Atf1 during G2/M transition 2017 FEMS Microbiology Letters, 364, 2017, fnx132 doi: 10.1093 #equalcontribution