Sonu Pahal

PhD-trained bioinformatician with expertise in C. elegans and cell culture, specializing in computational drug discovery and quantitative multi-omics analysis. Proficient in high-content imaging, LC-MS proteomics, and R/Python pipelines. Demonstrated success in collaborative, peer-reviewed research focused on ageing and Alzheimer’s disease.

• Pahal, Sonu, Nirjal Mainali, Meenakshisundaram Balasubramaniam, Robert J. Shmookler Reis, and Srinivas Ayyadevara. "Mitochondria in aging and age-associated diseases." Mitochondrion (2025): 102022.
• Pahal, Sonu,Vishvender Pahal, and Meenakshisundaram Balasubramaniam. "Tools of Artificial Intelligence in the Improvement of Synaptic Impairment in Different Neurodegenerative Diseases." In Synaptic Plasticity in Neurodegenerative Disorders, pp. 217-225. CRC Press, 2025.
• Pahal, Sonu, Vishvender Pahal, and Amit Chaudhary. "From data to discovery: Neuroinformatics in understanding Alzheimer's disease." Journal of Biosciences 50, no. 1 (2024): 2.
• Mainali, Nirjal, Meenakshisundaram Balasubramaniam, Sonu Pahal, W. Sue T. Griffin, Robert J. Shmookler Reis, and Srinivas Ayyadevara. "Altered protein homeostasis in cardiovascular diseases contributes to Alzheimer’s-like neuropathology." Basic Research in Cardiology (2025): 1-19.
• Ganne, Akshatha, Nirjal Mainali, Meenakshisundaram Balasubramaniam, Ramani Atluri, Sonu Pahal, Joseph Asante, Corey Nagel, Srikanth Vallurupalli, Robert J. Shmookler Reis, and Srinivas Ayyadevara. "Ezetimibe lowers risk of Alzheimer’s and related dementias over sevenfold, reducing aggregation in model systems by inhibiting 14-3-3G:: hexokinase interaction." Aging biology 2 (2024): 20240028.
• Pahal, Sonu, Ayushi Gupta, Princy Choudhary, Amit Chaudhary, and Sangeeta Singh. "Network pharmacological evaluation of Withania somnifera bioactive phytochemicals for identifying novel potential inhibitors against neurodegenerative disorder." Journal of Biomolecular Structure and Dynamics 40, no. 21 (2022): 10887-10898.
• Pahal, Sonu, Amit Chaudhary, and Sangeeta Singh. "Screening of natural compounds against SOD1 as a therapeutic target for amyotrophic lateral sclerosis." Letters in Drug Design & Discovery 19, no. 10 (2022): 877-887.
• Shukla, Richa, Sonu Pahal, Ayushi Gupta, Princy Choudhary, Krishna Misra, and Sangeeta Singh. "Modulation of GPCR receptors common to gut inflammatory diseases and neuronal disorders, Alzheimer’s and Parkinson’s diseases as druggable targets through Withania somnifera bioactives: an in silico study." Journal of Biomolecular Structure and Dynamics 41, no. 10 (2023): 4485-4503.
• Amod, Ayush, Sonu Pahal, Princy Choudhary, Ayushi Gupta, and Sangeeta Singh. "Network pharmacological evaluation of strigolactones efficacy as potential inhibitors against therapeutic targets of hepatocellular carcinoma." Biotechnology Letters 44, no. 7 (2022): 879-900.
• Gupta, Ayushi, Princy Choudhary, Sonu Pahal, and Sangeeta Singh. "Inhibition of SARS-CoV2 Replication Regulated by NSP3 through Ayurveda Phytoconstituents of Indian Traditional Medicine." In 2023 10th International Conference on Computing for Sustainable Global Development (INDIACom), pp. 478-483. IEEE, 2023.
• Choudhary, Princy, Shivani Gupta, Richa Shukla, Ayushi Gupta, Sonu Pahal, and Sangeeta Singh. "Regulation of neuronal repair and regeneration through inhibition of oligodendrocyte myelin glycoprotein (OMgp)." Journal of Biomolecular Structure and Dynamics 40, no. 24 (2022): 13936-13952.