Soroush Shahrokh

I am a third-year Hematology/Oncology Fellow at Texas Tech University Health Sciences Center in Lubbock, with a strong focus on patient-centered care. My training has emphasized clinical excellence in rural and underserved communities across Northwest Texas, where I have developed a deep commitment to community-based oncology.

I completed my Internal Medicine residency at the University of Houston College of Medicine in 2023 and hold a Master of Science in Clinical Pharmacology and Experimental Therapeutics. I bring strong clinical and research experience, including work in cancer drug resistance, immunotherapy, and translational oncology. I am especially interested in pursuing an attending role in private practice, serving rural communities, where I can continue to provide high-quality care and build lasting relationships with patients.

• 08/2023: Internal Medicine Board Certification
• 06/2023: Internal Medicine Residency completion certificate
• 05/2020: Doctor of Osteopathic Medicine Certification
• 07/2023 – Present: ACLS
• 06/2020 – Present: BLS
• 05/2018 – Present: CITI-training

• American Society of Clinical Oncology (ASCO)
• American Osteopathic Association (AOA)
• American College of Physicians (ACP)
• American Society for Pharmacology and Experimental Therapeutics (ASPET)
• Castleman’s Disease Collaborative Network (CDCN)

• Shahin, M., Fadavi, P., Ramandi, M. M. A., Shahrokh, S.
• & Taghizadeh-Hesary
• F. (2024). De novo myasthenia gravis in a patient with malignant melanoma after concurrent SARS-CoV-2 vaccination and immune checkpoint inhibitor therapy: Case report and literature review. eNeurologicalSci, 37, 100354. https://doi.org/10.1016/j.ensci.2024.100354
• Salemi, F., Mortazavizadeh, S. M. R., Zahir, S. T., & Shahrokh, S. (2023). Near-missed diagnosis of Merkel cell carcinoma in a young immunocompetent woman with a recurrent left-arm mass: A case report. Clinical case reports, 11(7), e7587. https://doi.org/10.1002/ccr3.7587
• Shahrokh, S., Salamian, S., & Shahin, M. (2022). Recurrent malignant ovarian adenocarcinoma with central nervous system metastasis successfully treated with paclitaxel, carboplatin, capecitabine, and gemcitabine. Proceedings (Baylor University. Medical Center), 36(2), 234–236. https://doi.org/10.1080/08998280.2022.1.39538
• Shahrokh, S., Salamian, S., Foroughi, Z., & Shahin, M. (2022). Successful treatment of recurrent esophageal squamous cell carcinoma with muscle metastasis using capecitabine and cetuximab. Proceedings (Baylor University. Medical Center), 35(6), 834–836. https://doi.org/10.1080/08998280.2022.1.201515
• Shahrokh, S., Shahabasi, M., & Naveri, R. K. (2022). Malignant mixed epithelial and stromal tumor of the kidney with rhabdomyosarcomatous transformation presenting with gross hematuria. Proceedings (Baylor University. Medical Center), 35(6), 837–839. https://doi.org/10.1080/08998280.2022.2090788
• Shahrokh, S., Rakhsha, A., Shahin, M., Jonavadezgan, A., Ahadi, M., Azghandi, S., & Taghizadeh-Hesary, F. (2022). Successful Treatment of Central Nervous System Histiocytic Sarcoma With Craniectomy and Adjuvant Radiotherapy. Cureus, 14(5), e26940. https://doi.org/10.7759/cureus.26940
• Shahrokh, S., Hebert, M., Jeong, W., & Guo, S. (2022). Burned-Out Testicular Germ Cell Tumor Presenting as Retroperitoneal Lymphadenopathy in a Patient With Cryptorchidism: A Case Report & Review of Literature. Cureus, 14(7), e26776. https://doi.org/10.7759/cureus.26776
• Shahrokh, S., Tran, D., Lines, B., & Bhurivala, M. N. (2022). Testicular Germ Cell Tumor Composed of Seminoma and Teratoma Metastasis as Choriocarcinoma to the Lungs Successfully Treated With Salvage Chemotherapy and Bone-Marrow Transplant: A Case Report. Cureus, 14(3), e22885. https://doi.org/10.7759/cureus.22885
• Shahrokh, S. & Faghankhani, M. & Jozayeri, A. & Youssefian, L. & Vahidnezhad, H. & Ziaee, V. & Saeidian, A.H. & Zeinali, S. & Uitto, J.. Pyrin-associated auto-inflammation with neutrophilic dermatosis (PAAND): Novel autosomal recessive MEFV mutation and successful treatment with colchicine. Journal of Investigative Dermatology. (2019, May); 139(5): S71.
• Shahrokh, S. & Hebert, M. & Jeong, W. & Guo, S. Burned-Out Testicular Germ Cell Tumor Presenting as Retroperitoneal Lymphadenopathy in a Patient With Cryptorchidism: A Case Report & Review of Literature. Cureus. (2022, Jul); 14(3): e26776.
• Shahrokh, S. & Nickbakht, J., Shahrokh, H. & Lafavi M.R.. Massive Abdominal Wall Desmoid Tumor Following Deep Dorsal Vein Ligation: A Case Report. Journal of Surgery. (2019, May); 111(1494): 1194.
• Shahrokh, S., Shahin, M., Abdolhasani, M., & Arefpour, A. M. (2022). Burned-Out Testicular Tumor Presenting as a Retroperitoneal Mass: A Case Report. Cureus, 14(1), e20603. https://doi.org/10.7759/cureus.21603
• Shahrokh, S., Shahin, M., Malboosfard, R., & Shayefar, N. (2021). Primary Undifferentiated Pleomorphic Thyroid Sarcoma Presenting as Superior Vena Cava Syndrome: A Case Report. Cureus, 13(12), e20104. https://doi.org/10.7759/cureus.20104
• Shahrokh, S., Hasan, A., Alim, S., Hebert, M., & Rizvi, K. (2022). Kikuchi-Fujimoto Disease Complicated by Rheumatoid Arthritis, Type 1 Diabetes Mellitus, and Hypothyroidism. Cureus, 14(1), e21008. https://doi.org/10.7759/cureus.21008.
• Sriscic, G. J., Mosley T, Prasad S, Heller J, Jallo J, Shahrokh S, Harrop JS. Etiology and Surgical Management of Cervical Spinal Epidural Abscesses (SEA): A Systematic Review. Global Spine J.. (2018, Dec); 8(4 Suppl): 59S-59S.
• Vahidnezhad, H. & Youssefian, L. & Saeidian, A. H. & Ziaee, V. & Mahmoudi, H. & Parvaneh, N. & Afshiee, B., & Shahrokh, S., & Taghizadeh-Hesary, F., & Soltani-Zangbar, M., & Jozayeri, M., & Youssefian, M., & Zeinali, S., & Uitto, J.. Homozygous MEFV Gene Variant and Pyrin-Associated Autoinflammation With Neutrophilic Dermatosis: A Family with a Novel Autosomal Recessive Mode of Inheritance. JAMA dermatology. (2021, Dec); 157(12): 1466-147
• Shahrokh, S. & Muzoki, K. & Rossi, G.. Expecting the Unexpected: When Use of Complementary Alternative Medicine Goes Wrong. American Journal of Psychiatry Residents' Journal. (2020, May); 15(3): 15-17.
• Shahrokh, S. & Mokhov, P. B.. Exploiting ROS-Generating Mechanisms for IFN-γ Therapy of Renal Cell Carcinoma. The FASEB Journal. (2017, April); 31(1_supplement): lb526-lb526.
• Ghafouri, S; Horn, R; Kamat, A; Parwar, D; Shahrokh, S; Tijani, L; Melkus, M; Singh, S. (2024, September 9); Targeting RLIP76 with a novel small molecule for lung cancer therapy. World Conference on Lung Cancer (WCLC 2024), 50th Annual Meeting Conference; San Diego, CA.
• Shahrokh, S. & Faghankhani, M. & Jozayeri, A. & Youssefian, L. & Vahidnezhad, H. & Ziaee, V., & Saeidian, A. H., & Zeinali, S. & Uitto, J.. (2019, May 1). Pyrin-associated auto-inflammation with neutrophilic dermatosis (PAAND): Novel autosomal recessive MEFV mutation and successful treatment with colchicine. Oral Presentation presented at: Society for Investigative Dermatology (SID) 77th Annual Meeting Conference; Chicago, IL.
• Shahrokh, S. & Mokhov, P. B. (2017, April 1). Exploiting ROS-Generating Mechanisms for IFN-γ Therapy of Renal Cell Carcinoma; Poster presented at: Experimental Biology; Chicago, IL.

English, Persian

• 03/2024– Present: Fellow Research Associate, Texas Tech University Health Sciences Center, Lubbock, TX, Dr. Sharda Singh
• Worked as part of a multidisciplinary team investigating novel therapeutic targets in lung cancer, I contributed to preclinical translational research in vitro cell culture techniques to evaluate the anticancer efficacy of small molecules across multiple lung cancer cell lines. Used various basic laboratory methods, including qRT-PCR analysis of tumor tissue to assess downstream signaling and treatment impact on cancer-related gene expression, and biochemical assays to examine drug-induced changes in caspase-3 activation and epigenetic regulators (HDAC, DNMT).
• This experience has strengthened my understanding of cancer biology and the importance of integrating evidence-based, mechanism-driven approaches into patient care, particularly valuable in underserved, rural community settings where access to cutting-edge treatments may be limited.
• 03/2024 – Present: Guest Manuscript Reviewer (Voluntary Editor), BMJ Connections in Oncology
• Participated in the peer review process as a guest reviewer for submitted oncology manuscripts, provided critical evaluation and constructive feedback to authors and editors to uphold journal quality standards, and contributed to the academic integrity and dissemination of oncology research within the BMJ publishing network.
• 06/2022 – Present: Guest Manuscript Reviewer (Voluntary Editor), Cureus Journal of Clinical Medicine
• Guest peer reviewer for the Cureus Journal of Medical Science. Reviewed and evaluated articles on solid tumors, hematologic malignancies, oncology clinical trials, immunotherapy, immune-related adverse events, and autoinflammatory disorders.
• Assessed the study’s research process and presentation of the results. Rated the article for publication and provided a detailed assessment of the study and comprehensive feedback to the study authors.
• 03/2022 – 06/2023: Resident Research Associate, University of Houston COM, Houston, TX
• The primary researcher on the systematic review and meta-analysis on the risk of immune-related adverse events in cancer patient treatment with immune checkpoint inhibitors and concurrent use of SARS-CoV-2 mRNA vaccine in patients with a previous history of SARS-CoV-2 infection. Used the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) method to evaluate and analyze the collected data to determine the risk of immune related adverse events in patient treated with immune checkpoint inhibitors following SARS-CoV-2 vaccine. Created schematic illustrations of the potential pathogenesis of irAEs caused by the synergistic immune response from concurrent administration of immune checkpoint inhibitors and inactivated SARS-CoV-2 vaccine. Prepared the original draft of the manuscript entitled “De novo myasthenia gravis in a patient with malignant melanoma after concurrent SARS-CoV-2 vaccination and immune checkpoint inhibitor therapy: Case report and literature review.”
• 03/2022 – 06/2023: Clinical Research Associate, Thomas Jefferson University Hospital, Philadelphia, PA
• Utilized online genomic tools and bioinformatic resources, including Cancer Genome Atlas, Genetic and Rare Diseases, Human Phenotype Ontology, NCBI Gene, Human Protein Atlas, and PubMed databases to create a comprehensive list of hereditary genodermatoses with increased cancer predisposition, their associated gene and protein abnormalities, clinical manifestations, and targeted treatment opportunities. Used Biorender to create schematic illustrations of abnormal signaling pathways and relevant target therapies. Performed data analysis, wrote the draft of the manuscript, and performed data curation to prepare the manuscript for submissions. Manuscript is currently under preparation; will be included as the primary author of the article entitled “Molecular Pathways of Hereditary Genodermatosis with Cancer Predisposition: Signaling Pathways & Therapeutic Opportunities.” Manuscript being prepared for submission to the European Journal of Dermatology.
• 01/2019 – 08/2019: Medical Student Researcher, Thomas Jefferson University Hospital, Philadelphia, PA
• Assisted in the case series study aimed at identifying the genetic basis of Pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND) in a consanguineous family and developing an effective genotype-guided treatment.
• Responsibilities included conducting patient interviews, collecting and interpreting clinical data, creating a pedigree, and utilizing genomic tools to identify and characterize the family’s genotype-phenotype correlation. Assisted with developing a genotype-guided treatment for PAAND with colchicine and low-dose steroids.
• Presented the study at the 77th Society for Investigative Dermatology annual meeting in Chicago, IL, which was selected for oral presentation. Assisted in manuscript preparation and was included as an author in the article “Homozygous MEFV Gene Variant and Pyrin-Associated Autoinflammation with Neutrophilic Dermatoogy Autoinflammation with Neutrophilic Dermatosis: A Family with a Novel Autosomal Recessive Mode of Inheritance,” published in JAMA dermatology.
• 08/2015 - 12/2016: Graduate Student Researcher, Fox Chase Cancer Center, Philadelphia, PA
• Worked as the primary researcher of the study exploring the efficacy of IFN-gamma with Piperlongumine in renal cell carcinoma. The study elucidated the cellular signaling pathways of IFN-gamma mediated tumor apoptosis and the role of reactive oxygen species in overcoming tumor resistance against IFN-gamma therapy.
• Developed study proposal, designed the study protocol, conducted experiments & interpreted the data. Presented the study progress to the thesis advisory committee. Performed advanced lab techniques including plasmid purification, real-time PCR, ELISA, Western & Southern blot, DNA extraction, plasmid purification, and TUNEL assay. Performed statistical data analysis, prepared the thesis manuscript, and presented and defended the study for my master’s thesis. Presented the study at the 2017 Experimental Biology meeting in Chicago.