Yanmeng Guo
San Francisco,CA
Summary
Highly motivated and goal-oriented Research Scientist with extensive experience in molecular and electrophysiological tools to study insect chemosensation, mechanosensation and behavior. Demonstrated expertise in receptors and ion channels that drive insect behavior. Proven ability to manage projects, develop and perform neurobiological techniques, and communicate results effectively. 15+ years of experience on ion channels and insect genetics & behavior.
Overview
9
9
years of professional experience
Work History
Specialist
Department Of Physiology, University Of California San Francis
07.2023 - Current
- Leading research on lysosomal mechanosensory ion channels in Drosophila and mice
- Published findings in top-tier journal Nature Cell Biology.
Associate Specialist
Department of Physiology, University of California San Francisco
07.2021 - 06.2023
- Conducted studies on peptide activation of ion channels mediating injury-induced nociception in Drosophila
- Submitted collaborative work for publication.
Postdoctoral Scholar
Department of Physiology, University of California San Francisco
10.2015 - 06.2021
- Investigated the role of TMC proteins in Drosophila larval locomotion and published in PNAS.
Education
Ph.D. in Neurobiology -
Institute of Neuroscience, Chinese Academy of Sciences
B.S. in Biotechnology - undefined
School of Life Science, Shandong University
Skills
Molecular Biology & Insect Genetics: Genome editing with Cas9 system
Electrophysiology: Whole-cell and outside-out patch recording, tip recording on Drosophila chemosensory bristles
Project Management: Driving science behind results and managing research projects
Keyresponsibilitiesachievements
Applied expertise in insect chemosensation, mechanosensation, ion channels and genetics to develop novel approaches to manipulate insect behavior. Independently designed and ran assays, analyzed data, and communicated results to stakeholders. Presented research findings at department meetings and international conferences. Prepared manuscripts for publication in peer-reviewed journals. Maintained awareness of relevant knowledge and technologies.
Publications
- Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels, Li K., Guo Y., et al., Nature Cell Biology, 2024
- Electron cryo-microscopy structure of the mechanotransduction channel NOMPC, Jin, P., Bulkley, D., Guo, Y., et al., Nature, 2017
- Transmembrane channel-like (tmc) protein regulates Drosophila larval locomotion, Guo Y., Wang Y., et al., PNAS, 2016
- The role of PPK26 in Drosophila larval mechanical nociception, Guo, Y., Wang, Y., et al., Cell Reports, 2014
- Drosophila TRPA channel painless inhibits male-male courtship behavior through modulating olfactory sensation, Wang, K., Guo, Y., et al., PLoS One, 2011
Timeline
Specialist
Department Of Physiology, University Of California San Francis
07.2023 - Current
Associate Specialist
Department of Physiology, University of California San Francisco
07.2021 - 06.2023
Postdoctoral Scholar
Department of Physiology, University of California San Francisco
10.2015 - 06.2021
Ph.D. in Neurobiology -
Institute of Neuroscience, Chinese Academy of Sciences
B.S. in Biotechnology - undefined
School of Life Science, Shandong University
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