Yaogang Zhong

• 2016, Excellence Graduate Student of Northwest University, China
• 2015, Graduate Student (Ph.D.) National Scholarship, China
• 2014, University First-Class Scholarship, Northwest University, China
• 2013, University First-Class Scholarship, Northwest University, China
• 2012, Graduate Student (M.S.) National Scholarship, China
• 2012, University First-Class Scholarship, Northwest University, China
• 2011, University First-Class Scholarship, Northwest University, China

• My early career contributions were focused on identification of the Glycan-binding proteins in human hepatic stellate cells LX-2 activated with TGF-β1. In this study, we found the precision alteration and localization of GBPs in human hepatic stellate cells (HSCs), which referred to pathological changes in HSCs may provide pivotal information to help understand the biological functions of glycans how to exert through their recognition by a wide variety of GBPs. This study could lead to the development of new anti-fibrotic strategies., Alteration and localization of Glycan-binding proteins in human hepatic stellate cells during liver fibrosis, Proteomics, 2015, 15, 3283-3295, Zhong Y, Qin Y, Dang L, Jia L, Zhang Z, Wu H, Cui J, Bian H, Li Z
• My graduate research contributions focused on the expression level of the terminal α2-3- and α2-6-linked sialic acids in human saliva from type 2 diabetes mellitus (T2DM), liver disease and gastric cancer (GC) patients and assess the binding activity of these linked sialic acids against influenza A viruses (IAV). This work observed that the expression level of the terminal α2-3-linked sialic acids of elderly individuals with T2DM and liver disease were down-regulated significantly, and the terminal α2-6 linked sialic acids were upregulated slightly or had no significant alteration. And, in the saliva of patients with GC, neither sialic acid was significantly altered. These findings may reveal that elderly individuals with chronic diseases, such as diabetes and liver disease, might be more susceptible to the avian influenza virus due to the decreased expression of terminal α2-3-linked sialic acids in their saliva, and the synthesis pathway of Glycopatterns and the expression and localization of Glycan-binding proteins in the development of hepatocellular carcinoma., Avian Influenza Virus Infection Risk in Humans with Chronic Diseases, Sci Rep, 2015, 5, 8971, Zhong Y, Qin Y, Yu H, Yu J, Wu H, Chen L, Zhang P, Wang X, Jia Z, Guo Y, Zhang H, Shan J, Wang Y, Xie H, Li X, Li Z, Serum Glycopatterns as Novel Potential Biomarkers for Diagnosis of Acute-on-Chronic Hepatitis B Liver Failure, Sci Rep, 2017, 7, 45957, Zhong Y, Guo Y, Liu X, Zhang J, Ma J, Shu J, Yang J, Zhang J, Jia Z, Li Z
• Postdoctoral Career: As a postdoctoral fellow, my research 1) To determine the molecular mechanism of how EGFR/PI3K signaling activates SREBP-1; 2) To investigate whether pharmacologic or genetic inhibition of SCAP suppresses GBM growth. Completion of this study may open a new avenue for treating GBM patients via directly inhibiting SCAP or SREBP-1 to avoid targeting overlapping upstream pathways that always induce tumor resistance, which may ultimately improve patient overall survival in the future.

English A, Tumor and Immunity A, Introductory Carbohydrate A, Bichemistry and Molecular Biology A, Biology A, Biomedicak information retrieval and use B, Gneomics B, Proteomics A, Molecular Immunology A, Zoology B, Marxism and Contemporary China A, Glycomics B, Alteration and localization of Glycan-binding proteins in human hepatic stellate cells during liver fibrosis, Proteomics, 2015, 15, 3283-3295, Zhong Y, Qin Y, Dang L, Jia L, Zhang Z, Wu H, Cui J, Bian H, Li Z, Avian Influenza Virus Infection Risk in Humans with Chronic Diseases, Sci Rep, 2015, 5, 8971, Zhong Y, Qin Y, Yu H, Yu J, Wu H, Chen L, Zhang P, Wang X, Jia Z, Guo Y, Zhang H, Shan J, Wang Y, Xie H, Li X, Li Z, Serum Glycopatterns as Novel Potential Biomarkers for Diagnosis of Acute-on-Chronic Hepatitis B Liver Failure, Sci Rep, 2017, 7, 45957, Zhong Y, Guo Y, Liu X, Zhang J, Ma J, Shu J, Yang J, Zhang J, Jia Z, Li Z

Professional Experience, 1. Avian Influenza Virus Infection Risk in Humans with Chronic Diseases using Lectin microarray and Lectin blotting. 2. Studying glycopatterns of salivary glycoproteins using Lectin microarray, MALDI-TOFMS and Lectin blotting. 3. Studying glycan-binding protein using Carbohydrate microarray, Cy/histochemistry and glycoprotomics. 4. Systematic comparison of glycopatterns in human saliva and sera in HBV-induced chronic hepatitis, cirrhosis, and hepatocellular carcinoma 5. Studying Glyco-related genes based molecular network analysis reveal using Glycorelated gene microarray and PT-PCR.

My career goal is to become an independent young investigator in brain tumor research from a postdoctoral researcher. I will learn and develop new research techniques that I can apply in future to achieve my career goal. I will attend the journal clubs and seminars as many as possible when I have free time. I also will collaborate with my colleagues and other people in the brain tumor research inside and outside of the Ohio State University. I will attend the scientific meetings such as the American Association for Cancer Research annual meeting. I will meet with my mentor Dr. Deliang Guo on a weekly basis to discuss the result and find a solution.

Title: Program Director/Principal Investigator