Yu Yang

Dynamic Sr. Scientist with extensive experience at Boehringer Ingelheim, excelling in LC-MS assay development and validation. Proven leadership in guiding teams to enhance method validation efficiency, while ensuring compliance with GLP/GCP standards. Skilled in analytical instrumentation and fostering collaboration across cross-functional teams to drive project success.

• Liquid Chromatographic Separation Using a 2 μm id Open Tubular Column at Elevated Temperature, Yang Y, Xiang P, Chen A, et al., Analytical Chemistry, 2021, 93, 10, 4361-4364
• Liquid Chromatography Using≤ 5 μm Open Tubular Columns, Xiang P, Yang Y, Chen H, et al., TrAC Trends in Analytical Chemistry, 2021, 116321
• Picoflow Liquid Chromatography–Mass Spectrometry for Ultrasensitive Bottom-Up Proteomics Using 2-μm-id Open Tubular Columns, Xiang P, Zhu Y, Yang Y, et al., Analytical Chemistry, 2020, 92, 7, 4711-4715
• Performing flow injection chromatography using a narrow open tubular column, Xiang, P., Yang, Y., Zhao, Z., Wang, J., Chen, M., Chen, A., & Liu, S., Analytica Chimica Acta, 2020, 1109, 19-26
• Non-porous thin dense layer coating: Key to achieving ultrahigh peak capacities using narrow open tubular columns, Yang Y, Liu S., Talanta Open, 2020, 1, 100003
• On-column and gradient focusing-induced high-resolution separation in narrow open tubular liquid chromatography and a simple and economic approach for pico-gradient separation, Yang Y, Xiang P, Chen H, et al., Analytica Chimica Acta, 2019, 1072, 95-101
• Experimentally validating open tubular liquid chromatography for a peak capacity of 2000 in 3 h, Xiang P, Yang Y, Zhao Z, et al., Analytical Chemistry, 2019, 91, 16, 10518-10523
• Ultrafast gradient separation with narrow open tubular liquid chromatography, Xiang P, Yang Y, Zhao Z, et al., Analytical Chemistry, 2019, 91, 16, 10738-10743
• Narrow, open, tubular column for ultrahigh-efficiency liquid-chromatographic separation under elution pressure of less than 50 bar, Yang Y, Chen H, Beckner M A, et al., Analytical Chemistry, 2018, 90, 18, 10676-10680
• Two-dimensional liquid chromatography consisting of twelve second-dimension columns for comprehensive analysis of intact proteins, Ren, J., Beckner, M. A., Lynch, K. B., Chen, H., Zhu, Z., Yang, Y., ... & Lu, J. J., Talanta, 2018, 182, 225-229
• Multiple-channel ultra-violet absorbance detector for two-dimensional chromatographic separations, Lynch K B, Yang Y, Ren J, et al., Talanta, 2018, 181, 416-421
• A narrow open tubular column for high efficiency liquid chromatographic separation, Chen H, Yang Y, Qiao Z, et al., Analyst, 2018, 143, 9, 2008-2011
• Tunable electroosmosis-based femto-liter pipette: a promising tool toward living-cell surgery, Chen, A., Lynch, K. B., Ren, J., Jia, Z., Yang, Y., Lu, J. J., & Liu, S., Analytical Chemistry, 2017, 89, 20, 10806-10812
• High-performance liquid chromatographic cartridge with gradient elution capability coupled with UV absorbance detector and mass spectrometer for peptide and protein analysis, Lynch K B, Chen A, Yang Y, et al., Journal of Separation Science, 2017, 40, 13, 2752-2758
• Sulfur-doped polyimide photocatalyst with enhanced photocatalytic activity under visible light irradiation, Wang C, Guo Y, Yang Y, et al., ACS Applied Materials & Interfaces, 2014, 6, 6, 4321-4328
• Developing high-efficiency π conjugated polymer semiconductor for photocatalytic degradation of dyes under visible light irradiation, Chu S, Wang C, Yang Y, et al., RSC Advances, 2014, 4, 100, 57153-57158

• A Novel, Sensitive, High-throughput Assay To Quantify Simultaneously Three Neurotransmitter Biomarkers in Human Plasma by Benzoyl Chloride Derivatization Coupled With UPLC-MS/MS, Muyang Li, Huiyu Zhou, Yang, Y, et al., WRIB, 2022
• A Robust, Simple, High-Throughput UPLC-MS/MS Assay To Quantify a Novel Biomarker, Phenylacetylglutamine, in Human Plasma, Yang, Y, et al., WRIB, 2022
• A Sensitive and High-throughput Assay to Quantify Lotepredonol Etabonate and Ketorolac Tromethamine in Human Urine Treated with SDS by SLE-UPLC-MS/MS, Yang, Y, et al., ASMS, 2022
• A Rapid, Robust, Sensitive and High-throughput UPLC-MS/MS Assay to Quantify Murine Double Minut2 (MDM2) -p53 Inhibitor Alrizomadlin in Human Plasma, Yang, Y, et al., ASMS, 2021
• A Simple, High-throughput, and Sensitive UPLC-MS/MS Assay to Quantify Abiraterone Acetate in Human Plasma, Yang, Y, et al., ASMS, 2021
• Narrow, open, tubular column for ultrahigh-efficiency liquid-chromatographic separation, Yang, Y, et al., Pittcon, 2019
• A Miniized High‐performance liquid chromatographic cartridge with gradient elution capability coupled with UV absorbance detector and mass spectrometer for peptide and protein analysis, Yang, Y, et al., ISCCxGCGC, 2017

Different sample purification techniques, such as PPE, SLE, LLE, SPE, affinity capture, immunocapture, enzymatic digestion, homogenization and etc., Agilent 1200 UPLC, Thermo Scientific Dionex UltiMate 3000 UHPLC, Capillary isoelectric focusing (cIEF), open tubular capillary LC, SCIEX Triple quadrople 7500, 6500+, Agilent 6400 series, The Agilent 6545 Q-TOF, Thermo Orbitrap Exploris 240, ICP-MS Agilent 8800, Laser-induced fluorescence (LIF) detection, UV-Vis detection, UV-vis DAD, fluorescent inverted microscope, Tomtec Quadra4 liquid handler, Hamilton Microlab STAR automated liquid handling platform, Biotage Extrahera HV-5000 automated sample preparation workstation, Chromeleon, Analyst, SCIEX OS, Watons LIMS, MaxQuant, Xcalibur, Matlab, Origin, Solidworks, LabView, LightTools, ChemDraw, Microsoft Office