Yusuph Mavura
Epidemiologist, Biostatistician And Bioinformatician Specializing In Human Genetics.
San Francisco,CA
Summary
Genetic epidemiologist, biostatistician and bioinformatician specializing in genomic and real-world data analysis, with focus on health outcomes in diverse populations. Proven track record in securing competitive funding and leading collaborative projects advancing precision medicine and public health.
Overview
7
7
years of professional experience
11
11
years of post-secondary education
2
2
Languages
Work History
Principal Investigator
University of California San Francisco
01.2023 - Current
- Wrote and secured the highly competitive NHGRI F99/K00 Predoctoral to Postdoctoral Transition Award as Principal Investigator with an exceptional impact score of 10, facilitating dissertation research on "Blood Pressure Polygenic Scores, Target Organ Damage, and Antihypertensive Drug Effects: Insights from Longitudinal Real-World Clinical Data."
- .Designed and executed comprehensive analyses of large-scale genomic and electronic health records (EHR) data to evaluate the clinical utility of polygenic risk scores in an ancestrally diverse real-world cohort.
Junior Principal Investigator
University of California, San Francisco
09.2019 - 12.2024
- Spearheaded a collaborative research project across multiple centers across the US in the $70 million NHGRI clinical sequencing exploratory research (CSER) consortium, focusing on assessment of diagnostic yield from genome and exome sequencing in over 3,000 ancestrally diverse prenatal, Neonatal intensive care unit (NICU), and pediatric cases.
- Analyzed and harmonized genomic, clinical and questionnaire data to demonstrate comparable diagnostic yield across genetic ancestries from exome and genome sequencing for diagnostic testing.
- Primary author to an empirical paper under review presenting primary diagnostic yield findings of CSER, advancing the understanding of genomic diagnostic testing in diverse populations.
PhD Student Researcher
University of California, San Francisco
09.2019 - 12.2024
- Analyzed diagnostic yield of exome sequencing in ancestrally diverse newborns with suspected metabolic disorders as part of the Newborn Sequencing (NBSeqNext) program at UCSF, contributing to the evaluation of genomic sequencing in newborn screening.
- Conducted pan-cancer, cross-tissue transcriptome-wide association study (TWAS) using UKBiobank and Genetic Epidemiology Research on Aging (GERA) cohort data to explore pleiotropic effects in cancer, enhancing understanding of shared genetic architecture across cancer types.
- Spearheaded collaborative study examining genomic rearrangement landscape in localized prostate cancer samples from Nigerian men of African descent, addressing critical gaps in genomic research diversity.
Master’s Researcher
Georgia Institute of Technology
08.2017 - 12.2018
- Analysis of mutations in cancer driver genes in matched primary, metastatic and recurrent ovarian cancer whole-exome sequencing samples (WES)
Intern
National Institutes of Health (NIH)
06.2018 - 08.2018
- Conducted a Genome-Wide Association study (GWAS) which identified multiple new risk loci for pancreatic cancer in East Asian populations
Education
Ph.D. - Epidemiology and Translational Science
University of California, San Francisco
San Francisco, CA 09.2019 - 03.2025
M.S. - Bioinformatics
Georgia Institute of Technology
Atlanta, GA 08.2017 - 12.2018
B.S. - Biochemistry and Molecular Biology
Jomo Kenyatta University of Agriculture And Technology
Nairobi, Kenya 05.2012 - 06.2016
Skills
- Exome/Genome sequence data analysis
- Clinical/mendelian genetics
- Complex disease genetics
- Population genetics
- Statistical genetics
- RNASeq data analysis
- Genetic epidemiology
- Causal inference using observational data
- General epidemiology and study design
- Grant writing
- Scientific communication and writing
- Python
- Bash scripting
- R
- Stata
- Perl
Publications
- Mavura Y, Song H, Xie J, Tamayo P, Mohammed A, Lawal AT, Bello A, Ibrahim S, Faruk M, Huang FW., Transcriptomic profiling and genomic rearrangement landscape of Nigerian prostate cancer., Prostate., 01/04/23, 10.1002/pros.24471, 36598071
- Kamran SC, Xie J, Cheung ATM, Mavura MY, Song H, Palapattu EL, Madej J, Gusev A, Van Allen EM, Huang FW., Tumor Mutations Across Racial Groups in a Real-World Data Registry., JCO Precis Oncol., 11/01/21, 10.1200/PO.21.00340, 34994651
- Oni-Orisan A, Mavura Y, Banda Y, Thornton TA, Sebro R., Embracing Genetic Diversity to Improve Black Health., N Engl J Med., 03/25/21, 10.1056/NEJMms2031080, 33567186
- Mavura MY, Huang FW., How Cancer Risk SNPs May Contribute to Prostate Cancer Disparities., Cancer Res., 07/15/21, 10.1158/0008-5472.CAN-21-1146, 34266915
- Yusuph Mavura, Nuriye Sahin-Hodoglugil, Ugur Hodoglugil, Mark Kvale, Pierre-Marie Martin, Jessica Van Ziffle, W. Patrick Devine, Sara L. Ackerman, Barbara A Koenig, Pui-Yan Kwok, Mary E. Norton, Anne Slavotinek, Neil Risch., Diagnostic Yield of Exome Sequencing in a Diverse Pediatric and Prenatal Population is not Associated with Genetic Ancestry., medRxiv., 05/24/23, 10.1101/2023.05.19.23290066, In Press at npj Genomic Medicine
- Yusuph Mavura, David Crosslin, Kathleen DM Ferar, John Greally, Lucia Hindorff, Gail P Jarvik, Sara Kalla, Barbara A Koenig, Mark Kvale, Pui-Yan Kwok, Mary Norton, Sharon E. Plon, Bradford C. Powell, Anne Slavotinek, Michelle L Thompson, Alice B Popejoy, Eimear E. Kenny, Neil Risch., Diagnostic yield of genome and exome sequencing in the ancestrally diverse CSER Phase II consortium is not associated with genetic ancestry in a variety of clinical settings., In preparation
Memberships
American Society of Human Genetics (ASHG)
ASHG Career Development Committee 2025-2027
Timeline
Principal Investigator
University of California San Francisco
01.2023 - Current
Junior Principal Investigator
University of California, San Francisco
09.2019 - 12.2024
PhD Student Researcher
University of California, San Francisco
09.2019 - 12.2024
Ph.D. - Epidemiology and Translational Science
University of California, San Francisco
09.2019 - 03.2025
Intern
National Institutes of Health (NIH)
06.2018 - 08.2018
M.S. - Bioinformatics
Georgia Institute of Technology
08.2017 - 12.2018
Master’s Researcher
Georgia Institute of Technology
08.2017 - 12.2018
B.S. - Biochemistry and Molecular Biology
Jomo Kenyatta University of Agriculture And Technology
05.2012 - 06.2016
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