Amiya Kumar Ghosh

Scientist with extensive experience in research and development. Proven ability to lead groundbreaking projects, contributing to significant scientific advancements. Known for effective team collaboration and achieving results within dynamic environments. Proficient in data analysis and experimental design.

Published research articles in reputed peer reviewed journals

Reviewed research articles for many journals

Reviewed seed grant applications for OSU

• Senior Research Scientist, Department of Psychiatry and Behavioral Neuroscience, The Ohio State University, Columbus, Ohio, 01/2023, 12/2024
• Research Assistant Professor, Department of Neurology, The Ohio State University, Columbus, Ohio, 01/2019, 12/2023
• Research Assistant Professor, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, 01/2016, 12/2018
• Research Investigator, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, 01/2012, 12/2016

• Research Specialist, University of Michigan, Ann Arbor, Michigan, 01/2010, 12/2012
• Research Associate, Northwestern University, Evanston, Illinois, 01/2003, 12/2004

• Research Fellow, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, 01/2008, 12/2010
• Post-doctoral Fellow, University of Connecticut Health Science Center, Farmington, Connecticut, 01/2004, 12/2008
• Research Fellow, Department of Rheumatology, Immunology and Allergy, Brigham & Women’s Hospital, Harvard University, Boston, Massachusetts, 01/2000, 12/2003

• 5R01EY029159-04, A Novel Inflammatory Cell with Neuroprotective and Neuro-regenerative Properties, Co-Investigator, Benjamin Segal, 04/01/18, 03/31/23, $902,312
• 1R01EY028350-01, Immune-Mediated Regeneration of Retinal Ganglion Cell Axons following Optic Nerve Trauma, Co-Investigator, Benjamin Segal, 09/01/17, 05/31/21, $510,045
• 5 P30 AG024824-15, Claude D. Pepper Older Americans Independence Centers (OAICs), Co-Investigator, Raymond L Yung, 07/2015, 06/2020, $905,301
• F043686, Epigenetic modulation of senescence in aging adipose tissue by plasma factors, Principal Investigator, 07/2016, 06/2018, $90,478
• F040620, Autophagy activity and adipose tissue mediated inflammation in aging, Principal Investigator, 08/2015, 07/2016, $40,000

• Ghosh AK. and Pyter L., Mechanistic insights into chemotherapy-mediated circadian disruption and behavioral side effects., Trends in Neurosciences, in preparation
• Ghosh AK. and Pyter L., SCN rhythm disruption by chemotherapy agent, paclitaxel manifest fatigue and depressive-like behavior in running wheel activities in mice., Blood, Brain, and Behavior (BBA), in preparation
• Mau T, O'Brien M, Ghosh AK, Miller RA, and Yung R., Lifespan extension drug interventions affect adipose tissue inflammation in aging., J. Gerontol. A Bio Sci. Med. Sci., 75, 1, 89-98, 2020, 31353414
• Ghosh AK, O'Brien M, Mau T, Qi N, and Yung R., Adipose tissue senescence and inflammation in aging is reversed by the young milieu., Journal of Gerontology: Biological Sciences, 74, 11, 1709-1715, 2019, 30590424
• Ghosh AK, Mau T, O'Brien M, Yung R., Novel role of autophagy associated Pik3c3 gene in gonadal white adipose tissue browning in aged C57/Bl6 male mice., Aging (Albany NY), 10, 4, 764-774, 2018, 29695642
• Ghosh AK, O'Brien M, Mau T, Yung R., Toll-like receptor 4 (TLR4) deficient mice are protected from adipose tissue inflammation in aging., Aging (Albany NY), 9, 9, 1971-1982, 2017, 2889820
• Ghosh AK, Mau T, O'Brien M, Garg S. and Yung R., Impaired autophagy activity is linked to elevated ER- stress and inflammation in aging adipose tissue., Aging, 8, 10, 2525-2537, 2016, 27777379
• Ghosh AK, Garg SK, Mau T, O'Brien M, Liu J, Yung R., Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging., Journal of Gerontology: Biological Sciences, 70, 11, 1320-1329, 2015, 25324219
• Slaats, G.G. Ghosh, A.K.
• Et al., Nephronophthisis-associated CEP164 regulates cell cycle progression, apoptosis, and epithelial-to-mesenchymal transition., PLOS Genetics, 10, 10, 1-14, 2014, 25340510
• Zhou, W., Otto, E.A., Cluckey, A., Airik, R., Hurd, T.W., Chaki, M., Diaz, K., Lach, F.P., Bennett, G.R., Ghosh, A.K. et al., FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic renal failure to DNA damage response signaling., Nature Genetics, 44, 8, 910-5, 2012, 22772369
• Chaki, M., Airik, R., Ghosh, AK. et al., Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling., Cell, 150, 3, 533-48, 2012, 22863007
• Otto, E.A., Hurd, T.W., Airik, R., Chaki, M., Zhou, W., Stoetzel, C., Patil, S.B., Levy, S., Ghosh, A.K. et al., Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy., Nature Genetics, 42, 10, 840-850, 2010, 20835237
• Li L, Khan N, Hurd T, Ghosh AK. et al., Ablation of the X-linked Retinitis Pigmentosa 2 (Rp2) gene in mice results in opsin mis localization and photoreceptor degeneration., 54, 7, 4503-11, 2013, 23745007
• Ghosh, AK., Hurd, T.W., & Hildebrandt, F., 3D-spheroid defects in nphp knockdown cells are rescued by the somatostatin agonist octreotide., American Journal of Physiology-Renal Physiology, 303, F1225–F1229, 2012, 22832925
• Ghosh, AK., Murga-Zamalloa, C.A. et al., Human retinopathy-associated ciliary protein Retinitis Pigmentosa GTPase Regulator (RPGR) regulates cilia-dependent vertebrate development., Human Molecular Genetics, 19, 1, 90-8, 2010, 19815619
• Murga-Zamalloa, C.A., Ghosh, AK., Patil, S.B., Reed, N.A., et al., Accumulation of RAF-1 kinase inhibitory protein (RKIP) is associated with CEP290-mediated photoreceptor degeneration in ciliopathies., J Biol Chem., 286, 32, 28276-86, 2011, 21685394
• Otto, E.A., Ramaswami, G., Janssen, S., Chaki, M, Allen, S.J., Zhou, W., Airik, R., Hurd, T.W., Ghosh, AK., et al., Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next-generation sequencing strategy., Journal of Medical Genetics, 48, 2, 105-16, 2011, PMC3913043, 21068128
• Ghosh, AK., & Basu, S., Tumor macrophages as a target for capsaicin-mediated Immunotherapy., Cancer Letters, 324, 1, 91-7, 2012, 22579786
• Ghosh, AK., & Basu, S., Fas-associated factor1 is a negative regular in capsaicin-induced cancer cell apoptosis., Cancer Letters, 287, 2, 142-9, 2010, 19570606
• Beltran, J., Ghosh, AK., & Basu, S., Immunotherapy of Tumors with Neuro-immune Ligand Capsaicin., Journal of Immunology, 177, 3260-3264, 2007, 17312175
• Duan L., Reddi AL., Ghosh AK., Dimri, M., Band H., The Cbl Family and other Ubiquitin Ligases: Destructive Forces in Control of Antigen Receptor Signaling., Immunity, 21, 7-17, 2004, 15345216
• Ghosh AK., Reddi A.L., Rao N.L., Duan, L., Band V., Band H., Biochemical basis for the requirement for kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase., J. Biol. Chem., 279, 34, 36132-36141, 2004, 15208330
• Rao, N., Ghosh, AK., Zhou P., Andoniou CE., Douillard P.and Band H., An essential role of ubiquitination in Cbl mediated negative regulation of the Src-family kinase Fyn., Signal Transduction, 1-3, 1-11, 2002, 19966925
• Rao, N., Miyake S., Reddi AL., Douillard P., Ghosh AK., Dodge I., Zhou P., Fernandes ND., Band H., Negative regulation of Lck by Cbl ubiquitin ligase., PNAS, 99, 6, 3794-3799, 2002, 122603
• Rao N, Ghosh AK. et al., The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation., EMBO J., 20, 24, 7085-95, 2001, 11742985
• Ghosh, AK., Jana, S. et al., Protection by Protein A of Apoptotic Cell Death caused by Anti-AIDS Drug, Zidovudine., Biochem. Biophys. Res. Commun., 264, 2, 601-604, 1999, 10529409
• Sinha, P., Ghosh, AK., Das, T., Sa, G. and Ray, PK., Protein A evokes Th1 Response in mice., Immunology Letters, 67, 157-165, 1999, 10369122
• Ghosh A.K., Das T., Sa, G., Sinha, P. and Ray, PK., S. aureus Superantigen Protein A expands CD4+/CD8+/CD19+/CD34+ cells in mice., Biochem. Biophys. Res. Commun., 256, 1, 142-146, 1999, 10066438

• Served as a reviewer on NIH grant applications to the study section., 11/2023
• Critical review and proofreading of manuscripts for publications from the Institute of Behavioral Neurosciences (NRI).
• Senior advisor for laboratory operations, manage institutional safety and compliances, teach and train students and post-docs.
• Served as a judge for selecting oral presentation candidates at the Neuroscience Retreat., The Ohio State University, 2022
• Served as a reviewer for Seed Grant Application at The Neuroscience Institute (NRI)., The Ohio State University, 2021
• Write Institutional biosafety committee (IBC) protocols for research activities.
• Served as a reviewer for multiple peer-reviewed journals: Brain Behavior and Immunity (BBI), Psychiatry Research, Chemosphere, Journal of Gerontology (JOG), Aging, Neuroscience.

• Featured in Annual Neurological Research Institute (NRI), OSU Newsletters., 2023
• Certificate of recognition by Departmental Chair and Director of Neurology, OSU for reviewing seed-grant applications., 2024
• Recognized in Annual Neurological Research Institute (NRI), OSU Newsletters., 2024

• Sir Nilratan Sirkar Prize for Best Research Scholar of the Year, Bose Institute
• Michigan Older American Independence Center (OAIC) Research Career Development Award (KL2 award)

• Understanding cancer and chemotherapy-mediated circadian clock disruptions and behavioral outcome.
• Neuroimmune interactions during cancer, brain injury, and neurological diseases.
• Understanding the mechanism of diet-induced and aging-associated inflammation and metabolic diseases.
• Feeding behavior with circadian time and impact on metabolic health.

• Neuro-regenerative myeloid cells are Hypoxia inducible factor-1a (Hif-1a) dependent., Neuroscience Retreat, The Ohio State University, 2021
• Autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue., The 21st IAGG World Congress of Gerontology & Geriatrics, 07/2017, San Francisco
• Understanding epigenetic mechanisms of senescence and inflammation in aging adipose tissue: Protective role of young plasma., University of Michigan-Research Career Development Core (RCDC)- seminar, 02/2017, Ann Arbor, Michigan
• The renal ciliopathy gene product CEP164 regulates DNA-damage-induced cell cycle progression., American Society of Nephrology Kidney week, 11/2012, San Diego, CA
• Functional analysis of X-Linked Retinitis Pigmentosa (XLRP) –associated mutations in RPGR., Kellogg Eye Center, University of Michigan, 09/2009, Ann Arbor
• Role of protein A in ameliorating Zidovudine induced hematopoietic toxicity., 10th International Congress on Immunology, 11/1998, New Delhi, India