JMP
Daniel Catlin
Senior Scientist
San Diego,CA
Summary
Enthusiastic and results-driven structural Biologist with a Ph.D. in Biochemistry. Throughout my academic journey and postdoctoral work, I led groundbreaking projects in structure-based drug design, driving swift advancements in drug discovery. Transitioning to industry, I applied my expertise to spearhead projects across various areas, from early R&D to product development. Actively seeking cutting-edge technologies, I am eager to merge my scientific acumen with the latest advancements, accelerating scientific exploration. Committed to proactive problem-solving and collaborations, I am passionate about driving transformative outcomes at the intersection of biology and technology.
Overview
4
4
years of professional experience
Work History
Senior Scientist
Bio-Techne
05.2023 - Current
- Lead particle-based development of technologies to quantify over 10 small molecule drugs from human serum.
- Knowledgeable of detection risks/issues stemming from cross reactive species, such as pro-drugs and off-target metabolites.
- Leverage structural expertise to guide computational investigations for predicting protein sequences for targeting small molecules.
- Site technical lead for troubleshooting issues on legacy products and initiating new projects.
Senior Scientist
Illumina
10.2021 - 04.2023
- Comprehensive protein engineering to manipulate various structure-function characteristics.
- Applied rational and structural analysis in design phase followed by rigorous biochemical characterization.
- Robust collaborations were maintained within other intradepartmental groups to support multiple projects.
- Supported design and development of internal computational pipelines.
Senior Scientist
Abbott
12.2020 - 09.2021
- Immediate team expert for structural biology.
- Played pivotal role in developing innovative technology as key team member.
- Actively contributed to construction of compelling case study showcasing company's capabilities in field that was new to the organization.
- Interacted with stakeholders across diverse technical domains, underscoring a robust comprehension of process design. Identified crucial junctures to successfully transition projects from early R&D phases to product development.
Postdoctoral Researcher
University Of Illinois, Urbana-Champaign
10.2019 - 12.2020
- Advanced new era of antibiotics through elucidation and characterization of biosynthetic enzymes situated in natural product synthesis pathways.
- Used statistical and analytical software to identify and explore gene clusters of interest.
- Contributed structural insight and expertise to collaborations focusing on chemo-enzymatic synthesis of molecules.
Education
Ph.D. - Chemistry
Loyola University of Chicago
Chicago, IL10.2019
Bachelor of Science - Chemistry
Carthage College
Kenosha, WI05.2013
Skills
Structure Biology
Software
Python
GraphPad Prism
PyMOL
Chimera
MOE
Selected Publications
- Structure Basis for The Hydrolytic Dehalogenation of The Fungicide Chlorothalonil, Daniel S. Catlin, Xinhang Yang, Brian Bennett, Richard C. Holz, and Dali Liu, Journal of Biological Chemistry, 2020, jbc.RA120.013150. DOI:10.1074/jbc.RA120.013150
- (S)-4-Amino-5-phenoxypentanoate as a Selective Agonist of the Transcription Factor GabR, Daniel S. Catlin, Cory T. Reidl, Thomas R. Trzupek, Richard B. Silverman, Brian Cannon, Daniel P. Becker, and Dali Liu, Protein Science, 2020
- Mechanism of Action of (1S,3S)-3-amino-4-(perfluoropropan-2-ylidene)cyclopentane-1-carboxylic acid hydrochloride, a potent inhibitor of ornithine aminotransferase, Matthew J. Moschitto, Peter F. Doubleday, Daniel S. Catlin, Neil L. Kelleher, Dali Liu, and Richard B. Silverman, Journal of the American Chemical Society, 2019 141 (27), 10711-10721, DOI: 10.1021/jacs.9b03254
- Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ, Kenneth D. Clevenger, Romila Mascarenhas, Daniel Catlin, Rui Wu, Neil L. Kelleher, Eric J. Drake, Andrew M. Gulick, Dali Liu, and Walter Fast, ACS Chemical Biology, 2017 12 (3), 643-647
POSTERS & PRESENTATIONS
· Graduate Research Student Symposium, Loyola University Chicago (March 2019): The Detection of DNA On and OFF States in Bacterial Infections
· Denkewalter Seminar, Loyola University Chicago (November 2017), Poster: Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ
· Midwest Enzyme Chemistry Conference (October 2017), Poster: Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ
LEADERSHIP / MENTORSHIP
· Graduate Lab Lead
· Graduate Research Mentor
· Theta Chi Delta Chapter President
· Chemistry Club & E-Board President
OUTREACH
· Emerging Science Workshops (2015 -2019)
· Mc’Nair Program (2015-2016)
· ACS SEED (2015-2018)
· United Way (2014)
· Passport To Science (2012-2013)
· Science At St. Joe’s (2011- 2013)
Affiliations
· Alpha Sigma Nu
· Theta Chi Delta
· American Chemical Society
Timeline
Senior Scientist
Bio-Techne
05.2023 - Current
Senior Scientist
Illumina
10.2021 - 04.2023
Senior Scientist
Abbott
12.2020 - 09.2021
Postdoctoral Researcher
University Of Illinois, Urbana-Champaign
10.2019 - 12.2020
Ph.D. - Chemistry
Loyola University of Chicago
Bachelor of Science - Chemistry
Carthage College