Po-Yuan Chen

Postdoctoral researcher with over 10 years of experience in development utilizing zebrafish models. Expertise in Notch signaling, vitamin B6 metabolism, and hematopoietic stem cell development. Proficient in CRISPR/Cas9 gene editing, behavioral assays, and in situ hybridization, contributing to significant advancements in biomedical research. Recognized for innovative problem-solving and effective collaboration within diverse research teams.

• Characterizing the impact of KITLG on pigmentation and hematopoiesis in zebrafish larvae Feb 2021- Jun 2021
• Establishing pyridoxamine 5’- phosphate conditional knockout zebrafish model through Crispr-Cas9 Sep 2019- Jun 2021
• Establishing and characterizing neonatal epilepsy by knocking down pyridoxamine 5’- phosphpat in zebrafish larvae Sep 2015- Sep 2020
• Investigating the mechanism of vitamin B6 toxicity in epileptic zebrafish larvae Sep 2013- Sep 2017
• Characterizing the effects of resveratrol on the vasodilation of rats Sep 2010- Jun 2013

• NCKU Thesis Competition Oral 2021
• 5th International Vitamin Conference Poster and flash talk 2018
• 2017 Taiwan Zebrafish Symposium Poster 2017
• 9th European Zebrafish Meeting Poster 2015
• 2014 Taiwan Zebrafish Symposium Oral 2014

• Po-Yuan Chen, Yi-Wen Tsai, Alice YW Chang, Hui-Hua Chang, Ya-Hsin Hsiao, Chin-Wei Huang, Pi-Shan Sung, Bing-Hung Chen, Tzu-Fun Fu. Increased leptin-b expression and metalloprotease expression contributed to the pyridoxine-associated toxicity in zebrafish larvae displaying seizure-like behavior. Biochemical Pharmacology. 2020 Dec;182:114294.
• Po-Yuan Chen, Hung-Chi Tu, Verne Schirch, Martin K. Safo and Tzu-Fun Fu. Pyridoxamine Supplementation Effectively Reverses the Abnormal Phenotypes of Zebrafish Larvae With PNPO Deficiency. Frontiers in Pharmacology. 2019 Sep 20;10:1086
• Gang-Hui Lee, Chia-Lin Chang, Wen-Tai Chiu, Tsun-Hsien Hsiao, Po-Yuan Chen, Kuan-Chieh Wang, Cheng-Hsiang Kuo, Bing-Hung Chen, Guey-Yueh Shi, Hua-Lin Wu, Tzu-Fun Fu. A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish. Journal of Biomedical Science. 2019 Aug 26;26(1):60.