Roshan Padmanabhan
Director, Informatics
Cleveland,OH
Summary
Dynamic bioinformatics leader with nearly two decades of experience, specializing in single-cell genomics and multiomic data integration. Pioneered the implementation of generative AI solutions and machine learning approaches for biological data analysis, demonstrating adaptability to emerging technologies. Proven track record in leading complex projects and cross-functional teams, with expertise in developing scalable computational infrastructure and fostering collaborative innovation. Successfully built and deployed cutting-edge analysis pipelines integrating single-cell genomics, machine learning, and multiomic data to drive scientific discoveries.
Overview
21
21
years of professional experience
Work History
Director of Informatics
Trailhead Biosystems
06.2024 - Current
- Created an Informatics strategic roadmap to foster a data- and AI- driven culture, accelerating automation, and digital transformation
- Developed an IP Invoice database utilizing generative AI for structured data extraction and text classification
- Developed a visualization prototype of human cell type hierarchy utilizing D3.js, Next.js
- Developed high-performing teams by providing mentorship, guidance, and opportunities for professional growth
- Manage computational infrastructure (cloud, in-house) and oversee IT integration
Senior Bioinformatics Scientist
Trailhead Biosystems
01.2022 - 05.2024
- Led comprehensive bioinformatics projects including cell fate space construction from single-cell datasets
- Implemented ML and deep learning algorithms to identify attractors in biological data
- Developed custom in-house database for transcriptomics data storage (bulk and single cell) and front-end applications for data querying and analysis
- Tailored NGS nextflow pipelines and R markdown workflows for in-house data analysis
- Managed Azure cloud infrastructure, created efficient ETL pipelines, and formulated data engineering strategies
- Mentored interns and coworkers, demonstrating leadership and collaborative skills
Bioinformatics Scientist
University Hospitals
05.2020 - 12.2021
- Integrated multiomic data (ChIP-Seq, ATAC-Seq, RNA-Seq) to study Krüppel-like transcription factors in vascular biology
- Developed downstream analysis pipelines for HiC data and deployed custom visualization tools
- Managed over 10 epigenomic and transcriptomics projects, showcasing project management expertise
Postdoctoral Bioinformatics Fellow
Cleveland Clinic
11.2016 - 05.2020
- Identified multiomic signatures correlating metabolomics with microbial datasets.
- Developed machine learning pipelines for classifying microbes associated with Autism Spectrum Disorder.
- Investigated the role of PTEN in transcription using ChIP-Seq and RNA-Seq methods.
- Germline variant analysis of Children, Adolescents, and Young Adults (C-AYA) with Solid Tumor.
Bioinformatics Engineer
Institute Of Cardiovascular And Metabolic Diseases
05.2015 - 06.2016
- Analyzed enhanced clinical and metagenomic dataset through advanced machine learning algorithms.
- Developed pipelines for 16s Amplicon, Shotgun Metagenomics, and Bulk RNA-Seq datasets.
Senior Research Fellow
Hyderabad Central University
03.2006 - 10.2011
- Conducted phylogenetic studies on the Lipoxygenase gene family, and acquired advanced techniques in embryonic stem cell culturing for regenerative medicine research.
Bioinformatician
JNCASR
09.2004 - 02.2006
- Assembled and annotated HIV genomes, contributed to comparative genomics of HIV genomes studies.
Education
Ph.D. -
School of Medicine, Aix-Marseille University
Marseille, France 05.2001 -
Master of Science - Marine Biotechnology
Goa University
Goa, IndiaAdvanced Post Graduate Diploma in Bioinformatics -
Jawaharlal Nehru University
New Delhi, IndiaBachelor of Science - Biotechnology
Kerala University
Kerala, IndiaSkills
Project management
Team management
Generative AI
Data Science
Multiomic Integration
Single Cell Analysis
Python, R, SQL, MongoDB, Neo4j
scikit-learn, PyTorch, Pydantic, FastAPI, Streamlit
Objective
Senior Director of BioInformatics
Timeline
Director of Informatics
Trailhead Biosystems
06.2024 - Current
Senior Bioinformatics Scientist
Trailhead Biosystems
01.2022 - 05.2024
Bioinformatics Scientist
University Hospitals
05.2020 - 12.2021
Postdoctoral Bioinformatics Fellow
Cleveland Clinic
11.2016 - 05.2020
Bioinformatics Engineer
Institute Of Cardiovascular And Metabolic Diseases
05.2015 - 06.2016
Senior Research Fellow
Hyderabad Central University
03.2006 - 10.2011
Bioinformatician
JNCASR
09.2004 - 02.2006
Ph.D. -
School of Medicine, Aix-Marseille University
05.2001 -
Master of Science - Marine Biotechnology
Goa University
Advanced Post Graduate Diploma in Bioinformatics -
Jawaharlal Nehru University
Bachelor of Science - Biotechnology
Kerala University
Similar Profiles
Lance HollisLance Hollis
Salesforce Intern – RPA & Design at Salesforce TrailheadSalesforce Intern – RPA & Design at Salesforce Trailhead
Christine LangeChristine Lange
Accounting Support Specialist at Trailhead Credit UnionAccounting Support Specialist at Trailhead Credit Union
Shelley EggersShelley Eggers
Real Estate Agent at Homes of Idaho- Trailhead Realty GroupReal Estate Agent at Homes of Idaho- Trailhead Realty Group
Carla AtlasCarla Atlas
Owner of White Gloves Cleaning Services at Owner Carla AtlasOwner of White Gloves Cleaning Services at Owner Carla Atlas
Alani Branche RamirezAlani Branche Ramirez
Lead Associate at AldiLead Associate at Aldi